Potential Mechanism and Therapeutic Targets of Polymyositis

doi:10.29271/jcpsp.2024.07.805

科研成果详情

题名	Potential Mechanism and Therapeutic Targets of Polymyositis
作者	Ye He 1; Junjie Zheng 2; Jing Luo 2; Fei Liao 1; Mingzhi Hong 3; Xiaochun Zhu2
发表日期	2024-07
发表期刊	Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Bioinformatics DEGs Hub genes Polymyositis Potential therapeutic agents
摘要	To investigate the variability in the expression profile of genes associated with polymyositis (PM), explore the potential molecular mechanisms underlying PM, and predict novel targets for intervention., Descriptive study. Place and Duration of the Study: Department of Rheumatology, Taizhou Municipal Hospital, Taizhou, China, from August to November 2023., Three microarray datasets (GSE3112, GSE39454, and GSE128470) were extracted from the gene expression omnibus (GEO). The analysis of this research involved identifying the differentially expressed genes (DEGs) in PM compared to normal samples. Enrichment analysis, gene-microRNA, gene-transcription factor (TF), and protein-protein interaction (PPI) network studies were conducted to identify hub genes and relevant pathways. Additionally, the drug-gene interaction database (DGIdb) was used to predict therapeutic medications., Eighty-eight DEGs were identified. The enrichment analysis results highlighted the significant involvement of downregulated DEGs in antigen processing and presentation. Based on the PPI networks, seven hub genes with high connectivity degrees were selected including a cluster of differentiation 74 (CD74), human leukocyte antigen (HLA)-DPA1, HLA-B, guanylate-binding protein 1 (GBP1), recombinant 2', 5'-oligoadenylate synthetase 1 (OAS1), HLA-C, and HLA-E., This research screened-out core genes, projected prospective therapeutic medications, discovered DEGs between PM and normal samples, and offered fresh perspectives for additional research into the possible mechanism and therapeutic targets of PM., Polymyositis, DEGs, Hub genes, Bioinformatics, Potential therapeutic agents.
ISSN	1022-386X
EISSN	1681-7168
卷号	34 期号:7 页码:805-810
DOI	10.29271/jcpsp.2024.07.805
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38978245
SCOPUSEID	2-s2.0-85198304156
通讯作者地址	[Zhu, Xiaochun]Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Medicine (all)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215733
专题	附属第一医院_风湿免疫科
作者单位	1.Department of Rheumatology, Taizhou Municipal Hospital, Taizhou, China.; 2.Department of Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.; 3.Department of Burns and Plastic Surgery, Taizhou Municipal Hospital, Taizhou, China.
通讯作者单位	附属第一医院
推荐引用方式 GB/T 7714	Ye He,Junjie Zheng,Jing Luo,et al. Potential Mechanism and Therapeutic Targets of Polymyositis[J]. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP,2024,34(7):805-810.
APA	Ye He, Junjie Zheng, Jing Luo, Fei Liao, Mingzhi Hong, & Xiaochun Zhu. (2024). Potential Mechanism and Therapeutic Targets of Polymyositis. Journal of the College of Physicians and Surgeons--Pakistan : JCPSP, 34(7), 805-810.
MLA	Ye He,et al."Potential Mechanism and Therapeutic Targets of Polymyositis".Journal of the College of Physicians and Surgeons--Pakistan : JCPSP 34.7(2024):805-810.