Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach

doi:10.1016/j.ijbiomac.2024.133584

科研成果详情

题名	Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach
作者	Haoyu Qiu 1; Lisha Gong 1; Paul Slezak 2; Shixiong He 3; Fei Lu 1; Kun Yu 1; Jing Xie4; Zhen Geng 5; Enling Hu 6; Zhihang Zhou 7; Guangqian Lan 8; Ruiqi Xie 9
发表日期	2024-07-01
发表期刊	International journal of biological macromolecules 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Differential drug release Microneedle Silk fibroin
其他关键词	PYLORI
摘要	The Helicobacter pylori infection in the stomach is the key reason for gastric mucosal bleeding. Eliminating gastric Helicobacter pylori by oral treatment remains difficult due to the presence of the gastric mucosal layer, which acts as a physical barrier to drugs via oral administration. In this study, a magnetic-navigable microneedle drug delivery platform (MNsD) for oral administration, featuring differential dual-mode drug release rate, was designed to fulfil rapid gastric hemostasis and overcome the gastric barriers for long-lasting Helicobacter pylori inhibition in stomach. MNs-D was created by rationally loading the carrier substrate, which was composed of silk fibroin with variable solubility, with antibiotics and hemostats. In vitro experiments showed MNs-D may sustainably eradicate Helicobacter pylori in stimulated gastric juices with long-lasting drug release (79 % in 24 h) and quickly establish hemostasis with instant drug release (92 % within 60 s). Most importantly, in vivo studies demonstrated MNs-D overcame the unsettling gastric mucosal barrier in traditional therapies of oral administration by insertion into the GML under magnetic navigation, resulting in sustained antibiotic release for long-lasting Helicobacter pylori eradiation (99 %). For differential dual-mode medication release against gastric Helicobacter pylori infections, this study may have firstly examined the effects of magnetic navigated microneedles administered orally.
资助项目	Health Joint Medical Scientific Research Foundation [2024ZDXM031]; Ernst Mach Grant Scholarship from Austrian Federal Ministry of Education, Science and Research [MPC-2022-04099]
出版者	ELSEVIER
ISSN	0141-8130
EISSN	1879-0003
卷号	275 期号:Pt 1
DOI	10.1016/j.ijbiomac.2024.133584
页数	15
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001265993700001
收录类别	PUBMED ; SCIE ; EI ; SCOPUS
EI入藏号	20242716647529
EI主题词	Antibiotics
EI分类号	461.6 Medicine and Pharmacology
URL	查看原文
PubMed ID	38960271
SCOPUSEID	2-s2.0-85197413837
通讯作者地址	[Hu, Enling;Lan, Guangqian;Xie, Ruiqi]Southwest Univ, Coll Sericulture Text & Biomass Sci, State Key Lab Resource Insects, Chongqing 400715, Peoples R China. ; [Xie, Ruiqi]Ludwig Boltzmann Inst Traumatol, AUVA Res Ctr, A-1200 Vienna, Austria. ; [Hu, Enling]Hong Kong Polytech Univ, Sch Fash & Text, Hong Kong, Peoples R China. ; [Zhou, Zhihang]Chongqing Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Chongqing 400010, Peoples R China.
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215681
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院附属第一医院_口腔科
作者单位	1.State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China.; 2.Ludwig Boltzmann Institute for Traumatology, AUVA Research Center, Vienna 1200, Austria.; 3.Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon 999077, Hong Kong.; 4.Department of Stomatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.; 5.Institute of Translational Medicine, Organoid Research Center, National Center for Translational Medicine (Shanghai) SHU Branch, Shanghai University, Shanghai 200444, China.; 6.State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; School of Fashion and Textiles, The Hong Kong Polytechnic University, Hong Kong. Electronic address: enling.allen.hu@connect.polyu.hk.; 7.Department of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address: zhouzhihang@cqmu.edu.cn.; 8.State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China. Electronic address: j070218@swu.edu.cn.; 9.State Key Laboratory of Resource Insects, College of Sericulture, Textile and Biomass Sciences, Southwest University, Chongqing 400715, China; Ludwig Boltzmann Institute for Traumatology, AUVA Research Center, Vienna 1200, Austria. Electronic address: xie.ruiqi@connect.polyu.hk.
推荐引用方式 GB/T 7714	Haoyu Qiu,Lisha Gong,Paul Slezak,et al. Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach[J]. International journal of biological macromolecules,2024,275(Pt 1).
APA	Haoyu Qiu., Lisha Gong., Paul Slezak., Shixiong He., Fei Lu., ... & Ruiqi Xie. (2024). Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach. International journal of biological macromolecules, 275(Pt 1).
MLA	Haoyu Qiu,et al."Magnetic-navigable silk fibroin microneedles for oral drug delivery: Ensuring long-lasting helicobacter pylori eradication and rapid hemostasis in the stomach".International journal of biological macromolecules 275.Pt 1(2024).