Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility

doi:10.1016/j.ijbiomac.2024.133458

科研成果详情

题名	Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility
作者	Zhang, Sisi 2; Jia, Erna 3,5; Zhang, Weiqi1; Wang, Zhiying3; Deng, Da 3; Zhang, Yixin 1; Huang, Xuefeng2; Tian, Qingquan 6; Tan, Ying 3,5; Wang, Bujun 4; Lin, Feng 1
发表日期	2024-08
发表期刊	International Journal of Biological Macromolecules 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Alginate Endometrial repair and regeneration Injectable hydrogels Intrauterine adhesion
其他关键词	INTRAUTERINE ADHESIONS ; REGENERATION
摘要	The development of novel therapeutic approaches to facilitate endometrial repair and regeneration while preventing adhesion recurrence is a crucial research objective aimed at enhancing clinical outcomes for women with intrauterine adhesions (IUA). In this study, we introduced an injectable Alg-GMA/PTSB zwitterionic hydrogel, characterized by excellent biocompatibility, anti-protein adsorption properties, and biodegradability. In a rat model, the hydrogel significantly promoted the regeneration and angiogenesis of damaged endometrial tissue, leading to improved recovery of epithelial cells, glands, proliferation, and vascularization. Furthermore, it exhibited the ability to suppress cellular apoptosis and collagen deposition, thereby mitigating fibrosis. Additionally, the hydrogel restored the expression of estrogen/progesterone receptors and endometrial receptivity markers, contributing to enhanced embryo implantation and fertility. These findings underscore the potential of the hydrogel as a promising therapeutic strategy for addressing endometrial injury, reducing fibrosis, restoring fertility, and ultimately improving outcomes for women with IUA.
资助项目	Wenzhou Key Laboratory of Reproduction and Genetics Foundation[2022HZSY0051];University of Chinese Academy of Sciences[WIUCASQD2020004,WIUCASQD2023003];Bilateral industries R&D Program of Zhejiang[2021C04005];Zhejiang Provincial Natural Science Foundation of China[LQ24H040008]
出版者	Elsevier B.V.
ISSN	0141-8130
EISSN	1879-0003
卷号	275 期号:Pt 1
DOI	10.1016/j.ijbiomac.2024.133458
页数	11
WOS类目	Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
WOS研究方向	Biochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS记录号	WOS:001264311800001
收录类别	SCOPUS ; PUBMED ; SCIE ; EI
EI入藏号	20242716606034
EI主题词	Adhesion
EI分类号	461.1 Biomedical Engineering ; 461.9 Biology ; 461.9.1 Immunology ; 801.2 Biochemistry ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 913.5 Maintenance ; 951 Materials Science
URL	查看原文
PubMed ID	38945326
SCOPUSEID	2-s2.0-85197084350
通讯作者地址	[Tan, Ying]Joint Research Centre on Medicine,The Affiliated Xiangshan Hospital of Wenzhou Medical University,Ningbo,315700,China ; [Wang, Bujun]Department of Obstetrics,Pingyang People's Hospital of Wenzhou Medical University,Wenzhou,325499,China
Scopus学科分类	Structural Biology;Biochemistry;Molecular Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215576
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学其他_附属象山医院（象山县第一人民医院）其他_附属萧山医院（杭州市萧山区第一人民医院）
通讯作者	Tan, Ying; Wang, Bujun; Lin, Feng
作者单位	1.Department of Gynecology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 2.Department of Reproductive Medicine,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 3.Joint Research Centre on Medicine,The Affiliated Xiangshan Hospital of Wenzhou Medical University,Ningbo,315700,China; 4.Department of Obstetrics,Pingyang People's Hospital of Wenzhou Medical University,Wenzhou,325499,China; 5.Wenzhou Key Laboratory of Biophysics,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325000,China; 6.Hangzhou Kewan New Materials Technology Co.,Ltd,Hangzhou,311305,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属萧山医院（杭州市萧山区第一人民医院）; 附属象山医院（象山县第一人民医院）; 温州医科大学
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Sisi,Jia, Erna,Zhang, Weiqi,et al. Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility[J]. International Journal of Biological Macromolecules,2024,275(Pt 1).
APA	Zhang, Sisi., Jia, Erna., Zhang, Weiqi., Wang, Zhiying., Deng, Da., ... & Lin, Feng. (2024). Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility. International Journal of Biological Macromolecules, 275(Pt 1).
MLA	Zhang, Sisi,et al."Injectable alginate-based zwitterionic hydrogels promoting endometrial repair and restoring fertility".International Journal of Biological Macromolecules 275.Pt 1(2024).