结直肠癌患者卡培他滨化疗相关不良反应的风险评估及风险预测模型构建

doi:10.12173/j.issn.1008-049X.202404078

科研成果详情

题名	结直肠癌患者卡培他滨化疗相关不良反应的风险评估及风险预测模型构建
其他题名	Risk assessment and prediction model for capecitabine-induced chemotherapy-related adverse reactions in colorectal cancer patients
作者	陈少波1; 吴旭桃2; 邱雯慧1; 胡婷婷1
发表日期	2024-06-05
发表期刊	中国药师影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	结直肠癌卡培他滨化疗诱导的不良反应风险预测模型
其他关键词	Colorectal cancer ; Capecitabine ; Chemotherapy-induced adverse efects ; Risk prediction model
摘要	目的探究结直肠癌（CRC）患者卡培他滨化疗诱导不良反应（CIAEs的危险因素并构建CIAEs发生的风险预测模型。方法回顾性收集2021年1月至2023年12月于温州医科大学附属第一医院接受卡培他滨片治疗的根治性术后CRC患者临床资料。根据是否出现CIAEs分为CIAEs和非CIAEs(NCIAEs)组。采用t检验和卡方检验筛选差异变量。多因素Logistic回归探究CRC患者发生CIAEs的独立影响因素，并使用R软件构建CRC患者CIAEs风险预测模型。采用受试者工作特征曲线分析、校准曲线和决策曲线评估CIAEs发生风险预测模型的预测能力、校准能力和临床净获益。结果本研究共纳入253例接受卡培他滨片治疗的根治性术后CRC患者，201例发生CIAEs，恶心呕吐（69.96%）发生率最高。多因素Logistic回归结果表明，年龄[OR=3.018,95%CI(1.404,6.487),P=0.005]、预后营养指数[OR=0.129,95%CI(0.06,0.278),P <0.001]和系统炎症指数[OR=4.074,95%CI(1.316,12.615),P=0.015]是CRC患者发生CIAEs的独立影响因素。本研究所构建的CIAEs发生风险预测模型具有良好的预测能力、校准能力和临床净获益。结论 CIAEs发生风险预测模型可用于CRC患者CIAEs的个体化预测，是预防CIAEs和护理管理过程中一种简单实用的工具。
其他摘要	Objective To explore the risk factors of chemotherapy-induced adverse reactions(CIAEs)caused by capecitabine in colorectal cancer(CRC)patients and to construct a risk prediction model for CIAEs.Methods We retrospectively collected data from postoperative CRC patients treated with capecitabine tablets at our hospital between January 2021 and December 2023.Patients were divided into CIAEs and NCIAEs groups based on the presence or absence of CIAEs.Variable differences were screened using t-tests and chi-square tests.Stepwise multivariate logistic regression was employed to identify independent factors influencing CIAEs in CRC patients.Based on these independent risk factors,a risk prediction model for CIAEs in CRC patients was constructed using R software.The model's predictive ability,calibration,and clinical net benefits were evaluated using receiver operating characteristic(ROC)analysis,calibration curves,and decision curves.Results A total of 253 postoperative CRC patients treated with capecitabine were included in this study.Among them,201 patients developed CIAEs,with nausea and vomiting being the most common(69.96％).Multiple logistic regression results indicated that age[OR=3.018,95％CI(1.404,6.487),P=0.005],prognosis nutrition index[OR=0.129,95％CI(0.06,0.278),P＜0.001],and systematic inflammation index[OR=4.074,95％CI(1.316,12.615),P=0.015]were independent risk factors for CIAEs in CRC patients.The constructed risk prediction model demonstrated good predictive ability,calibration,and clinical net benefit.Conclusion The risk prediction model for CIAEs can be used for individualized prediction of CIAEs in CRC patients and serves as a simple and practical tool for CIAE prevention and nursing management.
资助项目	温州市科研项目（Y20210478）;
ISSN	1008-049X
卷号	27 期号:06 页码:992-998
DOI	10.12173/j.issn.1008-049X.202404078
页数	7
收录类别	CNKI ; 万方 ; 维普 ; ISTIC
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215406
专题	附属第一医院附属第一医院_急诊科附属第一医院_消化内科
通讯作者	胡婷婷
作者单位	1.温州医科大学附属第一医院消化内科; 2.温州医科大学附属第一医院急诊科
第一作者单位	附属第一医院; 消化内科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	陈少波,吴旭桃,邱雯慧,等. 结直肠癌患者卡培他滨化疗相关不良反应的风险评估及风险预测模型构建[J]. 中国药师,2024,27(06):992-998.
APA	陈少波, 吴旭桃, 邱雯慧, & 胡婷婷. (2024). 结直肠癌患者卡培他滨化疗相关不良反应的风险评估及风险预测模型构建. 中国药师, 27(06), 992-998.
MLA	陈少波,et al."结直肠癌患者卡培他滨化疗相关不良反应的风险评估及风险预测模型构建".中国药师 27.06(2024):992-998.