Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer

doi:10.1007/s10856-024-06802-1

科研成果详情

题名	Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer
作者	Lu, Kaiming 1; Pan, Xiongfeng 2; Zheng, Jinyu3; Cheng, Dezhi3; Zheng, Liangcheng3; Zhang, Xinbo 3
发表日期	2024-06-19
发表期刊	Journal of Materials Science: Materials in Medicine 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Biological organs Controlled drug delivery Diseases Infrared devices Irradiation Self assembly Targeted drug delivery Taxation Tumors Anti-tumors Drug release Green taxes In-vitro Indocyanine Green Non small cell lung cancer Photo-thermal Theranostics Vitro and in vivo Zeolitic imidazolate framework-8
其他关键词	ZIF-8 ; DELIVERY
摘要	This study leverages nanotechnology by encapsulating indocyanine green (ICG) and paclitaxel (Tax) using zeolitic imidazolate frameworks-8 (ZIF-8) as a scaffold. This study aims to investigate the chemo-photothermal therapeutic potential of ZIF-8@ICG@Tax nanoparticles (NPs) in the treatment of non-small cell lung cancer (NSCLC). An all-in-one theranostic ZIF-8@ICG@Tax NPs was conducted by self-assembly based on electrostatic interaction. First, the photothermal effect, stability, pH responsiveness, drug release, and blood compatibility of ZIF-8@ICG@Tax were evaluated through in vitro testing. Furthermore, the hepatic and renal toxicity of ZIF-8@ICG@Tax were assessed through in vivo testing. Additionally, the anticancer effects of these nanoparticles were investigated both in vitro and in vivo. Uniform and stable chemo-photothermal ZIF-8@ICG@Tax NPs had been successfully synthesized and had outstanding drug releasing capacities. Moreover, ZIF-8@ICG@Tax NPs showed remarkable responsiveness dependent both on pH in the tumor microenvironment and NIR irradiation, allowing for targeted drug delivery and controlled drug release. NIR irradiation can enhance the tumor cell response to ZIF-8@ICG@Tax uptake, thereby promoting the anti-tumor growth in vitro and in vivo. ZIF-8@ICG@Tax and NIR irradiation have demonstrated remarkable synergistic anti-tumor growth properties compared to their individual components. This novel theranostic chemo-photothermal NPs hold great potential as a viable treatment option for NSCLC.Graphical Abstract A novel nano-theranostic platform was developed by encapsulating indocyanine green and paclitaxel within a zeolitie imidazolate framework-8 (ZIF-8). This chemo-phototherapic agent demonstrated accurate tumor targeting and effective suppression effects on both tumor growth in non-small cell lung cancer.
资助项目	Wenzhou Municipal Science and Technology Bureau [Y2023899]; Wenzhou Municipal Science and Technology Bureau
出版者	SPRINGER
ISSN	0957-4530
EISSN	1573-4838
卷号	35 期号:1
DOI	10.1007/s10856-024-06802-1
页数	14
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001250988200002
收录类别	SCIE ; SCOPUS ; EI ; PUBMED
EI入藏号	20242516295716
EI主题词	Nanoparticles
EI分类号	461.2 Biological Materials and Tissue Engineering ; 761 Nanotechnology ; 933 Solid State Physics ; 951 Materials Science
URL	查看原文
PubMed ID	3889616
SCOPUSEID	2-s2.0-85196382409
通讯作者地址	[Zhang, Xinbo]Wenzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Wenzhou 325000, Peoples R China.
Scopus学科分类	Biophysics;Bioengineering;Biomaterials;Biomedical Engineering
SCOPUS_ID	SCOPUS_ID:85196382409
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215328
专题	附属第一医院附属第一医院_手术室附属第一医院_心胸外科其他_附属苍南医院（苍南县人民医院）
通讯作者	Zhang, Xinbo
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Operating Room, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Cangnan Hosp, Dept Thorac Surg, Wenzhou 325800, Peoples R China; 3.Wenzhou Med Univ, Affiliated Hosp 1, Dept Thorac Surg, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院; 手术室
通讯作者单位	附属第一医院; 心胸外科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lu, Kaiming,Pan, Xiongfeng,Zheng, Jinyu,et al. Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer[J]. Journal of Materials Science: Materials in Medicine,2024,35(1).
APA	Lu, Kaiming, Pan, Xiongfeng, Zheng, Jinyu, Cheng, Dezhi, Zheng, Liangcheng, & Zhang, Xinbo. (2024). Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer. Journal of Materials Science: Materials in Medicine, 35(1).
MLA	Lu, Kaiming,et al."Theranostic nanoparticles ZIF-8@ICG for pH/NIR-responsive drug-release and NIR-guided chemo-phototherapy against non-small-cell lung cancer".Journal of Materials Science: Materials in Medicine 35.1(2024).