Protective Effect of Pyrroloquinoline Quinone on Diabetic Cardiomyopathy in C57BL/6 Mice

科研成果详情

题名	Protective Effect of Pyrroloquinoline Quinone on Diabetic Cardiomyopathy in C57BL/6 Mice
作者	Xia, Xuru1; Gu, Binbin1; Shen, Sudan1; Wang, Qinxi 2; Xie, Zemi 2; Wu, Yuejin 2; Wu, Jie 2; Wang, Yin 2; Wang, Yi1
发表日期	2024
发表期刊	INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Diabetic cardiomyopathy pyrroloquinoline quinone myocardial fibrosis long noncoding RNA echocardiography
摘要	Diabetic cardiomyopathy is the complication of diabetes and a serious health risk for diabetics. Pyrroloquinoline quinone, is a food-derived vitamin. The aim of this study was to investigate whether pyrroloquinoline quinone has a protective effect on the myocardium of patients with diabetic cardiomyopathy. We designed five groups of mice; control, diabetic cardiomyopathy, diabetic cardiomyopathy+pyrroloquinoline quinone-L, diabetic cardiomyopathy+pyrroloquinoline quinone-M, and diabetic cardiomyopathy+pyrroloquinoline quinone-H, and determined the changes of diabetic cardiomyopathy in each group based on the echocardiographic results of the mice. In addition, we also observed the myocardial tissue specimens of mice and found myocardial fibrosis was lower in pyrroloquinoline quinone group mice. To further explore the mechanism of pyrroloquinoline quinone affecting myocardial fibrosis, we used reverse transcriptase-polymerase chain reaction to measure the long noncoding RNA associated with myocardial fibrosis in mice, and found the expression of metastasis associated lung adenocarcinoma transcript 1, growth arrestspecific 5, and KCNQ1OT1 were higher in the groups of pyrroloquinoline quinone. This also indicated that pyrroloquinoline quinone improved myocardial fibrosis by affecting metastasis associated lung adenocarcinoma transcript 1, growth arrestspecific 5, and KCNQ1OT1 expressions.
资助项目	Public Welfare Project of Zhejiang Provincial SCI And Tech Bureau [LGF19C080001]
出版者	INDIAN PHARMACEUTICAL ASSOC
ISSN	0250-474X
EISSN	1998-3743
卷号	86 页码:25-32
页数	8
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001253588800003
收录类别	SCIE
通讯作者地址	[Wang, Yi]Wenzhou Med Univ, Affiliated Hosp 1, Dept Nutr, Wenzhou 325000, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215286
专题	附属第一医院_营养科
通讯作者	Wang, Yin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Nutr, Wenzhou 325000, Peoples R China; 2.Hangzhou Med Coll, Sch Food Sci & Engn, Hangzhou 310013, Zhejiang, Peoples R China
第一作者单位	附属第一医院_营养科
通讯作者单位	附属第一医院_营养科
第一作者的第一单位	附属第一医院_营养科
推荐引用方式 GB/T 7714	Xia, Xuru,Gu, Binbin,Shen, Sudan,et al. Protective Effect of Pyrroloquinoline Quinone on Diabetic Cardiomyopathy in C57BL/6 Mice[J]. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES,2024,86:25-32.
APA	Xia, Xuru., Gu, Binbin., Shen, Sudan., Wang, Qinxi., Xie, Zemi., ... & Wang, Yi. (2024). Protective Effect of Pyrroloquinoline Quinone on Diabetic Cardiomyopathy in C57BL/6 Mice. INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 86, 25-32.
MLA	Xia, Xuru,et al."Protective Effect of Pyrroloquinoline Quinone on Diabetic Cardiomyopathy in C57BL/6 Mice".INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES 86(2024):25-32.