Gut Microbiota Moderates Multimodal Brain Structure-Function Integration and Behavioral Cognition in Growth Hormone Deficient Children

doi:10.1159/000539097

科研成果详情

题名	Gut Microbiota Moderates Multimodal Brain Structure-Function Integration and Behavioral Cognition in Growth Hormone Deficient Children
作者	Wang, Keren 1; Fu, Yuchuan1; Li, Lan 1; Zhang, Lingfeng1; Huang, Mei 1; Yan, Weihao1; Shan, Xiaoou2,3; Yan, Zhihan1,4,5; Lu, Yi 1,4,5
发表日期	2024-07
发表期刊	NEUROENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Brain Growth hormone deficiency Multimodal fusion Gut-brain axis Cognition
其他关键词	DISORDER
摘要	Introduction: Previous brain studies of growth hormone deficiency (GHD) often used single-modal neuroimaging, missing the complexity captured by multimodal data. Growth hormone affects gut microbiota and metabolism in GHD. However, from a gut-brain axis (GBA) perspective, the relationship between abnormal GHD brain development and microbiota alterations remains unclear. The ultimate goal is to uncover the manifestations underlying GBA abnormalities in GHD and idiopathic short stature (ISS). Methods: Participants included 23 GHD and 25 ISS children. The fusion independent component analysis was applied to integrate multimodal brain data (high-resolution structural, diffusion tensor, and resting-state functional MRI) covering regional homogeneity (ReHo), amplitude of low frequency fluctuations (ALFF), and white matter fractional anisotropy (FA). Gut microbiome diversity and metabolites were analyzed using 16S sequencing and proton nuclear magnetic resonance (1H-NMR). Associations between multimodal neuroimaging and cognition were assessed using moderation analysis. Results: Six independent components (IC) of ReHo, ALFF, and FA differed significantly between GHD and ISS patients, with three functional components linked to the processing speed index. GHD individuals showed higher levels of acetate, nicotinate, and lysine in microbiota metabolism. Higher alpha diversity in GHD strengthened connections between ReHo-IC1, ReHo-IC5, ALFF-IC1, and the processing speed index, while increasing agathobacter levels in ISS weakened the link between ALFF-IC1 and the speech comprehension index. Conclusions: Our findings uncover differing brain structure and functional fusion in GHD, alongside microbiota metabolism of short-chain fatty acids. Additionally, microbiome influences connections between neuroimaging and cognition, offering insight into diverse GBA patterns in GHD and ISS, enhancing our understanding of the disease's pathophysiology and interventions.
资助项目	National Natural Science Foundation of China [82100952, 82071902]; Wenzhou Science and Technology Bureau in China [Y20220269]
出版者	KARGER
ISSN	0028-3835
EISSN	1423-0194
卷号	114 期号:7 页码:698-708
DOI	10.1159/000539097
页数	10
WOS类目	Endocrinology & Metabolism ; Neurosciences
WOS研究方向	Endocrinology & Metabolism ; Neurosciences & Neurology
WOS记录号	WOS:001252525600001
收录类别	SCIE ; SCOPUS
URL	查看原文
PubMed ID	38679006
SCOPUSEID	2-s2.0-85196621782
通讯作者地址	[Yan, Zhihan;Lu, Yi]Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Yuying Childrens Hosp, Wenzhou, Peoples R China. ; [Yan, Zhihan;Lu, Yi]Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou, Peoples R China. ; [Yan, Zhihan;Lu, Yi]Wenzhou Key Lab Struct & Funct Imaging, Wenzhou, Peoples R China.
Scopus学科分类	Endocrinology, Diabetes and Metabolism;Endocrinology;Endocrine and Autonomic Systems;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215258
专题	附属第二医院_放射科第二临床医学院，附属第二医院、育英儿童医院附属第二医院_儿童内分泌科
通讯作者	Yan, Zhihan; Lu, Yi
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Radiol, Yuying Childrens Hosp, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 2, Dept Pediat Endocrinol, Wenzhou, Peoples R China; 3.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China; 4.Key Lab Struct Malformat Children Zhejiang Prov, Wenzhou, Peoples R China; 5.Wenzhou Key Lab Struct & Funct Imaging, Wenzhou, Peoples R China
第一作者单位	附属第二医院_放射科
通讯作者单位	附属第二医院_放射科
第一作者的第一单位	附属第二医院_放射科
推荐引用方式 GB/T 7714	Wang, Keren,Fu, Yuchuan,Li, Lan,et al. Gut Microbiota Moderates Multimodal Brain Structure-Function Integration and Behavioral Cognition in Growth Hormone Deficient Children[J]. NEUROENDOCRINOLOGY,2024,114(7):698-708.
APA	Wang, Keren., Fu, Yuchuan., Li, Lan., Zhang, Lingfeng., Huang, Mei., ... & Lu, Yi. (2024). Gut Microbiota Moderates Multimodal Brain Structure-Function Integration and Behavioral Cognition in Growth Hormone Deficient Children. NEUROENDOCRINOLOGY, 114(7), 698-708.
MLA	Wang, Keren,et al."Gut Microbiota Moderates Multimodal Brain Structure-Function Integration and Behavioral Cognition in Growth Hormone Deficient Children".NEUROENDOCRINOLOGY 114.7(2024):698-708.