Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data

doi:10.14744/AnatolJCardiol.2024.4369

科研成果详情

题名	Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data
作者	Yibin Mei 1; Fang Ye 1; Xiaofen Yin 2; Xianjun Wu 1
发表日期	2024-06-14
发表期刊	Anatolian journal of cardiology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Mendelian randomization atrial fibrillation heartfailure causal inference
其他关键词	EPIDEMIOLOGY ; INFERENCE
摘要	Atrial fibrillation (AF) and heart failure (HF) are prevalent cardiovascular conditions in East Asia, with a complex interrelationship. The directionality of the causal impact of AF on HF risk remains uncertain. This study employs Mendelian randomization (MR) to investigate the potential causal effect of AF on HF., Utilizing summary data from genome-wide association studies (GWAS) within the Medical Research Council Integrative Epidemiology Unit open GWAS database, we analyzed 8180 AF cases and 28 612 controls, alongside 9413 HF cases and 203 040 controls, all of East Asian descent. We conducted MR analysis using the inverse variance weighted (IVW) method, complemented by various sensitivity analyses, including bidirectional MR to assess causality in the reverse direction., Genetically predicted AF was found to be causally associated with an increased risk of HF in East Asian populations (odds ratio = 1.14, 95% CI: 1.10-1.19, P <.001) as per the IVW method. These findings were consistent across multiple MR methods. Sensitivity analyses revealed no significant heterogeneity or pleiotropy. Notably, bidirectional MR analysis showed no causal effect of HF on the risk of developing AF., The MR analysis supports a unidirectional causal relationship between AF and increased HF risk in East Asian individuals. The absence of a reverse causal effect reinforces the importance of maintaining sinus rhythm to mitigate HF risk. Further research is warranted to corroborate these findings and to explore their clinical implications in depth.
资助项目	Project of Zhejiang Provincial Scientific Research Foundation of Traditional Chinese Medicine [2021ZA147]
出版者	KARE PUBL
ISSN	2149-2263
EISSN	2149-2271
卷号	28 期号:8 页码:399-405
DOI	10.14744/AnatolJCardiol.2024.4369
页数	9
WOS类目	Cardiac & Cardiovascular Systems
WOS研究方向	Cardiovascular System & Cardiology
WOS记录号	WOS:001302436200006
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	38872495
SCOPUSEID	2-s2.0-85203280947
通讯作者地址	[Wu, Xianjun]Wenzhou Med Univ, Lishui Peoples Hosp, Affiliated Hosp 6, Dept Cardiol, Lishui, Zhejiang, Peoples R China. ; [Wu, Xianjun]Lishui Univ, Affiliated Hosp 1, Sch Med, Dept Cardiol, Lishui, Zhejiang, Peoples R China.
Scopus学科分类	Cardiology and Cardiovascular Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/215134
专题	附属第一医院其他_附属第六医院（丽水市人民医院）
作者单位	1.Department of Cardiology, Lishui People's Hospital, the Sixth Affiliated Hospital of Wenzhou Medical University, Lishui, Zhejiang, China;Department of Cardiology, First Affiliated Hospital of Lishui University School of Medicine, Lishui, Zhejiang, China.; 2.Liancheng Community Health Service Center, Lishui, Zhejiang, China.
第一作者单位	附属第一医院; 附属第六医院（丽水市人民医院）
通讯作者单位	附属第六医院（丽水市人民医院）
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Yibin Mei,Fang Ye,Xiaofen Yin,et al. Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data[J]. Anatolian journal of cardiology,2024,28(8):399-405.
APA	Yibin Mei, Fang Ye, Xiaofen Yin, & Xianjun Wu. (2024). Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data. Anatolian journal of cardiology, 28(8), 399-405.
MLA	Yibin Mei,et al."Causal Effect of Atrial Fibrillation on Heart Failure Risk in East Asian Ancestry: A Bidirectional Mendelian Randomization Study Using Genome-wide Association Data".Anatolian journal of cardiology 28.8(2024):399-405.