In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications

doi:10.1016/j.cej.2024.152763

科研成果详情

题名	In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications
作者	Tong, Xian1,2; Shen, Xinkun3; Lin, Zhiqiang1; Lu, Lei1; Munir, Khurram 4; Zhou, Runqi 5; Zhu, Li 1; Li, Yuncang 4; Ma, Jianfeng1; Wen, Cuie 4; Lin, Jixing1
发表日期	2024-08-01
发表期刊	Chemical Engineering Journal 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Binary alloys Degradation Elongation High strength alloys Hot rolling Magnesium alloys Scandium alloys Tensile strength Ternary alloys Zinc alloys Biodegradable zn-ag metal Guided bone regeneration Guided bone-regeneration membrane Hot-rolled In-vitro Infection models Osteogenesis Regeneration membrane Scandium Subcutaneous infection model
其他关键词	MECHANICAL-PROPERTIES ; ANTIBACTERIAL ABILITY ; ZINC-ALLOYS ; DEGRADATION BEHAVIOR ; BINARY-ALLOYS ; ZN ; MICROSTRUCTURE ; IMPLANT ; MG ; AG
摘要	Zinc-silver (Zn-Ag) alloys are generally promising guided bone-regeneration membrane (GBRM) materials due to their moderate degradability, osteogenic differentiation, and antibacterial properties. However, Zn-Ag alloys often display microstructural inhomogeneity and mechanical instability due to the formation of coarse Ag-rich second phases. In this study, Zn-4Ag and Zn-4Ag-0.1Sc (denoted ZA and ZAS, respectively) were comparatively investigated, and the ZAS exhibited a suitable degradation rate, high strength-elongation product, cytocompatibility, antibacterial capacity, and in vitro and in vivo osteogenic properties, making it highly appropriate for GBRM applications. Among all the as-cast and hot-rolled (HR) samples, the HR ZAS had the highest ultimate tensile strength of ∼260.5 MPa, tensile yield strength of ∼202.0 MPa, and elongation of ∼72.7%. The HR ZAS also exhibited a higher degradation rate of ∼36.5 µm/a in Hanks’ solution than those of the HR ZA, while its diluted extract was more cytocompatible and capable of osteogenic differentiation toward both MG-63 and MC3T3-E1 cells. The HR ZAS showed an exceptionally effective antibacterial ability against S. aureus in both in vitro antibacterial testing and in vivo subcutaneous infection models. Further, the HR ZAS demonstrated better osteogenic and histocompatibility properties than those of pure Zn in a rat skull defect model. © 2024 The Authors
资助项目	Zhejiang Public Welfare Technology Application Research Project of China[LTGY24H140002,LTGY23H140002,LGF22H140008];Australian Research Council[DP240101131]
出版者	Elsevier B.V.
ISSN	1385-8947
EISSN	1873-3212
卷号	493
DOI	10.1016/j.cej.2024.152763
页数	18
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS研究方向	Engineering
WOS记录号	WOS:001263716900001
收录类别	EI ; SCOPUS ; SCIE
EI入藏号	20242316201554
EI主题词	Silver alloys
EI分类号	531.1 Metallurgy ; 535.1.2 Rolling Mill Practice ; 542.2 Magnesium and Alloys ; 546.3 Zinc and Alloys ; 547.1 Precious Metals ; 549.2 Alkaline Earth Metals ; 549.3 Nonferrous Metals and Alloys excluding Alkali and Alkaline Earth Metals ; 802.2 Chemical Reactions
URL	查看原文
SCOPUSEID	2-s2.0-85194922764
通讯作者地址	[Zhou, Runqi]Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering,Higher Education and Stomatological Hospital,Chongqing Medical University,Chongqing,401174,China
Scopus学科分类	Chemistry (all);Environmental Chemistry;Chemical Engineering (all);Industrial and Manufacturing Engineering
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214710
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所其他_附属第三医院（瑞安市人民医院）
通讯作者	Zhou, Runqi; Ma, Jianfeng; Wen, Cuie; Lin, Jixing
作者单位	1.Institute of Stomatology, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou; 325027, China; 2.School of Materials Science and Engineering, Xiangtan University, Xiangtan; 411105, China; 3.Department of Orthopaedics, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Wenzhou; 325016, China; 4.Centre for Additive Manufacturing, School of Engineering, RMIT University, Melbourne; VIC; 3001, Australia; 5.Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering, Higher Education and Stomatological Hospital, Chongqing Medical University, Chongqing; 401174, China
第一作者单位	口腔医学院、附属口腔医院; 口腔医学研究所
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Tong, Xian,Shen, Xinkun,Lin, Zhiqiang,et al. In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications[J]. Chemical Engineering Journal,2024,493.
APA	Tong, Xian., Shen, Xinkun., Lin, Zhiqiang., Lu, Lei., Munir, Khurram., ... & Lin, Jixing. (2024). In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications. Chemical Engineering Journal, 493.
MLA	Tong, Xian,et al."In vitro and in vivo studies of a biodegradable Zn-4Ag-0.1Sc alloy with high strength-elongation product, cytocompatibility, osteogenic differentiation, and anti-infection properties for guided bone-regeneration membrane applications".Chemical Engineering Journal 493(2024).