A prospective, randomized, single-blinded study comparing the efficacy and safety of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography

doi:10.1186/s12871-024-02572-z

科研成果详情

题名	A prospective, randomized, single-blinded study comparing the efficacy and safety of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography
作者	Zhang, Wenyou1; Wang, Liangrong1; Zhu, Na1; Wu, Wenzhi2; Liu, Haiyan1
发表日期	2024-05-28
发表期刊	BMC Anesthesiology 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Dexmedetomidine Endoscopic retrograde cholangiopancreatography Propofol Sedation-related adverse events
其他关键词	CONSCIOUS SEDATION ; ERCP ; MIDAZOLAM ; REMIFENTANIL ; COMBINATION ; ANESTHESIA ; OUTCOMES
摘要	Background Balanced propofol sedation is extensively used in endoscopic retrograde cholangiopancreatography (ERCP), but sedation-related adverse events (SRAEs) are common. In various clinical settings, the combination of dexmedetomidine with opioids and benzodiazepines has provided effective sedation with increased safety. The aim of this investigation was to compare the efficacy and safety of dexmedetomidine and propofol for sedation during ERCP. Methods Forty-one patients were randomly divided into two groups: the dexmedetomidine (DEX) group and the propofol (PRO) group. Patients in the DEX group received an additional bolus of 0.6 mu g kg(-1) dexmedetomidine followed by a dexmedetomidine infusion at 1.2 mu g kg(-1) h(-1), whereas the PRO group received 1-2 mg kg(-1) of propofol bolus followed by a propofol infusion at 2-3 mg kg(-1) h(-1). During ERCP, the primary outcome was the incidence of hypoxemia (SpO(2) < 90% for > 10 s). Other intraoperative adverse events were also recorded as secondary outcomes, including respiratory depression (respiratory rate of < 10 bpm min(-1)), hypotension (MAP < 65 mmHg), and bradycardia (HR < 45 beats min(-1)). Results The incidence of hypoxemia was significantly reduced in the DEX group compared to the PRO group (0% versus 28.6%, respectively; P = 0.032). Patients in the PRO group exhibited respiratory depression more frequently than patients in the DEX group (35% versus 81%, respectively; P = 0.003). There were no significant differences in terms of hypotension and bradycardia episodes between groups. During the procedures, the satisfaction scores of endoscopists and patients, as well as the pain and procedure memory scores of patients were comparable between groups. Conclusion In comparison with propofol, dexmedetomidine provided adequate sedation safety with no adverse effects on sedation efficacy during ERCP.
出版者	BMC
ISSN	1471-2253
卷号	24 期号:1
DOI	10.1186/s12871-024-02572-z
页数	10
WOS类目	Anesthesiology
WOS研究方向	Anesthesiology
WOS记录号	WOS:001234480500001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38807059
SCOPUSEID	2-s2.0-85194821741
通讯作者地址	[Liu, Haiyan]Wenzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Shangcai Village,Nanbaixiang Town,Ouhai Dist, Wenzhou 325000, Peoples R China.
Scopus学科分类	Anesthesiology and Pain Medicine
SCOPUS_ID	SCOPUS_ID:85194821741
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214690
专题	附属第一医院附属第一医院_麻醉科附属第一医院_消化内科
通讯作者	Liu, Haiyan
作者单位	1.Wenzhou Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Shangcai Village,Nanbaixiang Town,Ouhai Dist, Wenzhou 325000, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Wenzhou 325000, Peoples R China
第一作者单位	附属第一医院; 麻醉科
通讯作者单位	附属第一医院; 麻醉科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhang, Wenyou,Wang, Liangrong,Zhu, Na,et al. A prospective, randomized, single-blinded study comparing the efficacy and safety of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography[J]. BMC Anesthesiology,2024,24(1).
APA	Zhang, Wenyou, Wang, Liangrong, Zhu, Na, Wu, Wenzhi, & Liu, Haiyan. (2024). A prospective, randomized, single-blinded study comparing the efficacy and safety of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography. BMC Anesthesiology, 24(1).
MLA	Zhang, Wenyou,et al."A prospective, randomized, single-blinded study comparing the efficacy and safety of dexmedetomidine and propofol for sedation during endoscopic retrograde cholangiopancreatography".BMC Anesthesiology 24.1(2024).