Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma

doi:10.3389/fphar.2024.1377370

科研成果详情

题名	Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma
作者	Lin, Zhili1; Wang, Quanqiang 1; Zheng, Ziwei1; Zhang, Bingxin1; Zhou, Shujuan1; Zheng, Dong1; Chen, Zixing2; Zheng, Sisi 1; Zhu, Shuxia1; Zhang, Xinyi1; Lan, Enqing2; Zhang, Yu 1; Lin, Xuanru 1; Zhuang, Qiang1; Qian, Honglan1; Hu, Xudong1; Zhuang, Yan1; Jin, Zhouxiang2; Jiang, Songfu1; Ma, Yongyong1,3,4
发表日期	2024-05-16
发表期刊	FRONTIERS IN PHARMACOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	multiple myeloma platelet prognostic gene signature immune microenvironments biological functions sensitivity to chemotherapeutic agents
其他关键词	CANCER ; CYTOKINES ; THERAPY ; REPAIR
摘要	Background: Significant progress has been achieved in the management of multiple myeloma (MM) by implementing high-dose therapy and stem cell transplantation. Moreover, the prognosis of patients has been enhanced due to the introduction of novel immunomodulatory drugs and the emergence of new targeted therapies. However, predicting the survival rates of patients with multiple myeloma is still tricky. According to recent researches, platelets have a significant impact in affecting the biological activity of tumors and are essential parts of the tumor microenvironment. Nonetheless, it is still unclear how platelet-related genes (PRGs) connect to the prognosis of multiple myeloma. Methods: We analyzed the expression of platelet-related genes and their prognostic value in multiple myeloma patients in this study. We also created a nomogram combining clinical metrics. Furthermore, we investigated disparities in the biological characteristics, immunological microenvironment, and reaction to immunotherapy, along with analyzing the drug susceptibility within diverse risk groups. Results: By using the platelet-related risk model, we were able to predict patients' prognosis more accurately. Subjects in the high-risk cohort exhibited inferior survival outcomes, both in the training and validation datasets, as compared to those in the low-risk cohort (p < 0.05). Moreover, there were differences in the immunological microenvironments, biological processes, clinical features, and chemotherapeutic drug sensitivity between the groups at high and low risk. Using multivariable Cox regression analyses, platelet-related risk score was shown to be an independent prognostic influence in MM (p < 0.001, hazard ratio (HR) = 2.001%, 95% confidence interval (CI): 1.467-2.730). Furthermore, the capacity to predict survival was further improved when a combined nomogram was utilized. In training cohort, this outperformed the predictive value of International staging system (ISS) alone from a 5-years area under curve (AUC) = 0.668 (95% CI: 0.611-0.725) to an AUC = 0.721 (95% CI: 0.665-0.778). Conclusion: Our study revealed the potential benefits of PRGs in terms of survival prognosis of MM patients. Furthermore, we verified its potential as a drug target for MM patients. These findings open up novel possibilities for prognostic evaluation and treatment choices for MM.
资助项目	National Natural Science Foundation [82270212]; Natural Science Foundation of Zhejiang province [LY20H080003]; Wenzhou Municipal Science and Technology Bureau [Y20220716]; Discipline Cluster of Oncology, Wenzhou Medical University, China [z2-2023023]
出版者	FRONTIERS MEDIA SA
ISSN	1663-9812
EISSN	1663-9812
卷号	15
DOI	10.3389/fphar.2024.1377370
页数	18
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001235137800001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38818376
SCOPUSEID	2-s2.0-85194868880
通讯作者地址	[Jiang, Songfu;Ma, Yongyong]Wenzhou Med Univ, Dept Hematol, Affiliated Hosp 1, Wenzhou, Peoples R China. ; [Jin, Zhouxiang]Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Hepatobiliary Surg, Wenzhou, Peoples R China. ; [Ma, Yongyong]Key Lab Intelligent Treatment & Life Support Crit, Wenzhou, Peoples R China. ; [Ma, Yongyong]Zhejiang Engn Res Ctr Hosp Emergency & Proc Digiti, Wenzhou, Peoples R China.
Scopus学科分类	Pharmacology;Pharmacology (medical)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214649
专题	附属第一医院_血液内科第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Jin, Zhouxiang; Jiang, Songfu; Ma, Yongyong
作者单位	1.Wenzhou Med Univ, Dept Hematol, Affiliated Hosp 1, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Hepatobiliary Surg, Wenzhou, Peoples R China; 3.Key Lab Intelligent Treatment & Life Support Crit, Wenzhou, Peoples R China; 4.Zhejiang Engn Res Ctr Hosp Emergency & Proc Digiti, Wenzhou, Peoples R China
第一作者单位	附属第一医院_血液内科
通讯作者单位	附属第一医院_血液内科; 第二临床医学院，附属第二医院、育英儿童医院
第一作者的第一单位	附属第一医院_血液内科
推荐引用方式 GB/T 7714	Lin, Zhili,Wang, Quanqiang,Zheng, Ziwei,et al. Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma[J]. FRONTIERS IN PHARMACOLOGY,2024,15.
APA	Lin, Zhili., Wang, Quanqiang., Zheng, Ziwei., Zhang, Bingxin., Zhou, Shujuan., ... & Ma, Yongyong. (2024). Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma. FRONTIERS IN PHARMACOLOGY, 15.
MLA	Lin, Zhili,et al."Identification and validation of a platelet-related signature for predicting survival and drug sensitivity in multiple myeloma".FRONTIERS IN PHARMACOLOGY 15(2024).