Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma

doi:10.1111/cas.16213

科研成果详情

题名	Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma
作者	Cao, Caineng1,2; Fang, Yuting1,2; Jiang, Feng 1,2; Jin, Qifeng 1,2; Jin, Ting 1,2; Huang, Shuang 1,2; Hu, Qiaoying 1,2; Chen, Yuanyuan 1,2; Piao, Yongfeng 1,2; Hua, Yonghong1,2; Feng, Xinglai 1,2; Chen, Xiaozhong 1,2,3
发表日期	2024-05-28
发表期刊	CANCER SCIENCE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	elderly patient geriatric assessment IMRT nasopharyngeal carcinoma nimotuzumab
其他关键词	GERIATRIC ASSESSMENT ; OLDER-ADULTS ; CANCER ; MULTICENTER
摘要	Because of the common physical condition, reduced organ function, and comorbidities, elderly patients with nasopharyngeal carcinoma (NPC) are often underrepresented in clinical trials. The optimal treatment of elderly patients with locally advanced NPC remains unclear. The purpose of this study was to evaluate the efficacy of concurrent nimotuzumab combined with intensity-modulated radiotherapy (IMRT) in elderly patients with locally advanced NPC. We conducted a single-arm, phase II trial for elderly patients with stage III-IVA NPC (according to UICC-American Joint Committee on Cancer TNM classification, 8th edition). All patients received concurrent nimotuzumab (200 mg/week, 1 week prior to IMRT) combined with IMRT. The primary end-point was complete response (CR) rate. The secondary end-points were survival, safety, and geriatric assessment. Between March 13, 2017 and November 12, 2018, 30 patients were enrolled. In total, 20 (66.7%) patients achieved CR, and objective response was observed in 30 (100.0%) patients 1 month after radiotherapy. The median follow-up time was 56.05 months (25th-75th percentile, 53.45-64.56 months). The 5-year locoregional relapse-free survival, distant metastasis-free survival, cancer-specific survival, disease-free survival, and overall survival were 89.4%, 86.4%, 85.9%, 76.5%, and 78.8%, respectively. Grade 3 mucositis occurred in 10 (33%) patients and grade 3 pneumonia in 3 (10%) patients. Concurrent nimotuzumab combined with IMRT is effective and well-tolerated for elderly patients with locally advanced NPC. Heterogeneous population of elderly nasopharyngeal carcinoma (NPC) patients was observed by geriatric assessment. Concurrent nimotuzumab with intensity-modulated radiotherapy (IMRT) is effective and well-tolerated for elderly patients with NPC. Concurrent nimotuzumab with IMRT merits further research in elderly patients with NPC.image
资助项目	Medical and Health Research Project of Zhejiang Province
出版者	WILEY
ISSN	1347-9032
EISSN	1349-7006
卷号	115 期号:8 页码:2729-2737
DOI	10.1111/cas.16213
页数	9
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001233226500001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38806289
SCOPUSEID	2-s2.0-85194878969
通讯作者地址	[Chen, Xiaozhong]Wenzhou Med Univ, Zhejiang Canc Hosp,Chinese Acad Sci, Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Hangzhou Inst Med HIM,Postgrad Training Base Allia, 1 East Banshan Rd, Hangzhou 310022, Peoples R China.
Scopus学科分类	Oncology;Cancer Research
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214629
专题	其他_浙江省肿瘤医院（浙江省癌症中心）
通讯作者	Chen, Xiaozhong
作者单位	1.Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med HIM, Dept Radiat Oncol, Hangzhou, Peoples R China; 2.Wenzhou Med Univ, Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Postgrad Training Base Alliance, Hangzhou, Peoples R China; 3.Wenzhou Med Univ, Zhejiang Canc Hosp,Chinese Acad Sci, Key Lab Head & Neck Canc Translat Res Zhejiang Pro, Hangzhou Inst Med HIM,Postgrad Training Base Allia, 1 East Banshan Rd, Hangzhou 310022, Peoples R China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学
推荐引用方式 GB/T 7714	Cao, Caineng,Fang, Yuting,Jiang, Feng,et al. Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma[J]. CANCER SCIENCE,2024,115(8):2729-2737.
APA	Cao, Caineng., Fang, Yuting., Jiang, Feng., Jin, Qifeng., Jin, Ting., ... & Chen, Xiaozhong. (2024). Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma. CANCER SCIENCE, 115(8), 2729-2737.
MLA	Cao, Caineng,et al."Concurrent nimotuzumab and intensity-modulated radiotherapy for elderly patients with locally advanced nasopharyngeal carcinoma".CANCER SCIENCE 115.8(2024):2729-2737.