Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients

doi:10.1177/15910199241256682

科研成果详情

题名	Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients
作者	Qiu, Linan 1,2; Zhang, Ye 1; Geng, Dandan1; Pan, Yuesong 3,4; Xu, Xueqian 1; Chen, Jiahao 1; Xu, Minjie1; Chen, Liuzhu 1; Tu, Yujie1; Huang, Yezhi1; Long, Jingfang1; Duan, Qi 1; Wu, Beilan1; Qiu, Huihua1; He, Jincai1
发表日期	2024-05-31
发表期刊	INTERVENTIONAL NEURORADIOLOGY 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Acute ischemic stroke endovascular treatment tirofiban eGFR renal function
其他关键词	HEALTH-CARE PROFESSIONALS ; MECHANICAL THROMBECTOMY ; INTRACRANIAL ATHEROSCLEROSIS ; ENDOTHELIAL DYSFUNCTION ; ENDOVASCULAR TREATMENT ; EARLY MANAGEMENT ; REOCCLUSION ; GUIDELINES ; ALTEPLASE ; UPDATE
摘要	Background: Acute ischemic stroke poses a significant health threat, and thrombectomy has become a routine treatment. Tirofiban has emerged as a promising adjunct therapy to minimize reocclusion after thrombectomy. We aimed to investigate whether renal function influences the safety and efficacy of tirofiban in patients undergoing endovascular therapy. Methods: Patients' clinical data collected from the stroke unit were analyzed. The modified Rankin scale score and symptomatic intracranial hemorrhage (sICH) were used as outcome measures. Results: A total of 409 patients (mean age: 66.5 years, 292 males [71.4%]) were included. Tirofiban significantly improved 3-month functional outcomes (adjusted odds ratio [aOR] = 2.408, 95% confidence interval [CI] 1.120-5.175), reduced 3-month mortality (aOR = 0.364, 95% CI 0.155-0.856), and decreased the incidence of sICH (aOR = 0.339, 95% CI 0.149-0.767) in patients with estimated glomerular filtration rate (eGFR) >= 90 mL/min/1.73 m(2). However, no significant improvement in prognosis was observed with tirofiban in patients with eGFR < 90 mL/min/1.73 m(2). Interaction analysis suggested a potential influence of renal function on tirofiban efficacy. Conclusion: Renal function may impact the efficacy of tirofiban. Administration of tirofiban in direct thrombectomy patients with normal renal function is safe and improves prognosis. However, the prognostic benefits of tirofiban are limited in patients with impaired renal function.
资助项目	National Natural Science Foundation of China [81873799]
出版者	SAGE PUBLICATIONS INC
ISSN	1591-0199
EISSN	2385-2011
DOI	10.1177/15910199241256682
页数	8
WOS类目	Clinical Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS研究方向	Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
WOS记录号	WOS:001236420600001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38819373
SCOPUSEID	2-s2.0-85194908572
通讯作者地址	[He, Jincai]Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China.
Scopus学科分类	Radiology, Nuclear Medicine and Imaging;Neurology (clinical);Cardiology and Cardiovascular Medicine
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214612
专题	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科其他_附属第五医院（丽水市中心医院）
通讯作者	He, Jincai
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Dept Neurol, Wenzhou 325000, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Lishui Cent Hosp, Lishui, Zhejiang, Peoples R China; 3.Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing, Peoples R China; 4.China Natl Clin Res Ctr Neurol Dis, Beijing, Peoples R China
第一作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科; 其他_附属第五医院（丽水市中心医院）
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
第一作者的第一单位	第一临床医学院（信息与工程学院）、附属第一医院_内科学_神经内科
推荐引用方式 GB/T 7714	Qiu, Linan,Zhang, Ye,Geng, Dandan,et al. Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients[J]. INTERVENTIONAL NEURORADIOLOGY,2024.
APA	Qiu, Linan., Zhang, Ye., Geng, Dandan., Pan, Yuesong., Xu, Xueqian., ... & He, Jincai. (2024). Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients. INTERVENTIONAL NEURORADIOLOGY.
MLA	Qiu, Linan,et al."Renal function affects the safety and efficacy of tirofiban in acute ischemic stroke thrombectomy patients".INTERVENTIONAL NEURORADIOLOGY (2024).