Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study

doi:10.3389/fendo.2024.1407503

科研成果详情

题名	Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study
作者	Kui, Lihong 1; Dong, Cheng 2; Wu, Junyu 3; Zhuo, Feinan4; Yan, Bin 5; Wang, Zhewei4; Yang, Meiling 1; Xiong, Canhai 1; Qiu, Peng 4
发表日期	2024-05-21
发表期刊	FRONTIERS IN ENDOCRINOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	acute suppurative otitis media (ASOM) type 2 diabetes mellitus (T2DM) hearing loss (HL) causal relationship Mendelian randomization (MR)
其他关键词	SURFACTANT PROTEIN-A ; EUSTACHIAN-TUBE ; HEARING ; INSTRUMENTS ; ADULTS ; DYSFUNCTION ; DEFINITION ; MANAGEMENT ; ETIOLOGY ; OBESITY
摘要	Background Type 2 diabetes mellitus (T2DM) and hearing loss (HL) constitute significant public health challenges worldwide. Recently, the association between T2DM and HL has aroused attention. However, possible residual confounding factors and other biases inherent to observational study designs make this association undetermined. In this study, we performed univariate and multivariable Mendelian Randomization (MR) analysis to elucidate the causal association between T2DM and common hearing disorders that lead to HL.Methods Our study employed univariate and multivariable MR analyses, with the Inverse Variance Weighted method as the primary approach to assessing the potential causal association between T2DM and hearing disorders. We selected 164 and 9 genetic variants representing T2DM from the NHGRI-EBI and DIAGRAM consortium, respectively. Summary-level data for 10 hearing disorders were obtained from over 500,000 participants in the FinnGen consortium and MRC-IEU. Sensitivity analysis revealed no significant heterogeneity of instrumental variables or pleiotropy was detected.Results In univariate MR analysis, genetically predicted T2DM from both sources was associated with an increased risk of acute suppurative otitis media (ASOM) (In NHGRI-EBI: OR = 1.07, 95% CI: 1.02-1.13, P = 0.012; In DIAGRAM: OR = 1.14, 95% CI: 1.02-1.26, P = 0.016). Multivariable MR analysis, adjusting for genetically predicted sleep duration, alcohol consumption, body mass index, and smoking, either individually or collectively, maintained these associations. Sensitivity analyses confirmed the robustness of the results.Conclusion T2DM was associated with an increased risk of ASOM. Strict glycemic control is essential for the minimization of the effects of T2DM on ASOM.
资助项目	Zhejiang Provincial Medical Health Science and Technology Plan [2024KY1246]
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	15
DOI	10.3389/fendo.2024.1407503
页数	10
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001237516700001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38836234
SCOPUSEID	2-s2.0-85195141212
通讯作者地址	[Qiu, Peng]Wenzhou Med Univ, Affiliated Hosp 1, Dept Rehabil, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214603
专题	附属第一医院_康复科
通讯作者	Qiu, Peng
作者单位	1.Xiamen Rehabil Hosp, Xiamen, Fujian, Peoples R China; 2.Shanghai Jiao Tong Univ, Ruijin Hosp, Dept Nucl Med, Sch Med, Shanghai, Peoples R China; 3.Shanghai Univ Sport, Sch Phys Educ, Shanghai, Peoples R China; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Rehabil, Wenzhou, Zhejiang, Peoples R China; 5.Jiangsu Vocat Coll Med, Sch Rehabil Med, Yancheng, Jiangsu, Peoples R China
通讯作者单位	附属第一医院_康复科
推荐引用方式 GB/T 7714	Kui, Lihong,Dong, Cheng,Wu, Junyu,et al. Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study[J]. FRONTIERS IN ENDOCRINOLOGY,2024,15.
APA	Kui, Lihong., Dong, Cheng., Wu, Junyu., Zhuo, Feinan., Yan, Bin., ... & Qiu, Peng. (2024). Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study. FRONTIERS IN ENDOCRINOLOGY, 15.
MLA	Kui, Lihong,et al."Causal association between type 2 diabetes mellitus and acute suppurative otitis media: insights from a univariate and multivariate Mendelian randomization study".FRONTIERS IN ENDOCRINOLOGY 15(2024).