Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis

doi:10.1136/lupus-2024-001156

科研成果详情

题名	Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis
作者	Zhao, Liling 1; Wang, Wenwen 2; Wu, Lijun 3,4; Wu, Tong 5; Tu, Jianxin6; Wu, Xue 3,4; Sun, Fangfang 1; Ding, Huihua 1; Shen, Nan 1,7; Wu, Huaxiang 2; Zhu, Jing 5; Sun, Li6; Ye, Shuang 1
发表日期	2024-05
发表期刊	LUPUS SCIENCE & MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Lupus Erythematosus, Systemic Lupus Nephritis Autoantibodies
其他关键词	MONOCLONAL-ANTIBODY ; B-CELLS ; CLASSIFICATION ; CRITERIA
摘要	Objectives To investigate the effectiveness of belimumab on active lupus nephritis (LN) and explore the predictors, including serological biomarkers, of renal response to belimumab in a real-world setting. Methods This multicentre, real-world observational study enrolled patients with active LN receiving intravenous belimumab as an add-on therapy with 24-hour urine protein >= 1 g and estimated glomerular filtration rate >= 30 mL/min/1.73 m(2 )at baseline. Complete renal response (CRR), partial renal response (PRR), no renal response (NRR) and primary efficacy renal response (PERR) were evaluated. Multivariable logistic regression was used to identify risk factors for NRR to belimumab at 6 months. Results Among the 122 patients enrolled, the proportions of patients achieving CRR, PRR, NRR and PERR were 35.9%, 17.1%, 47.0% and 44.4% at 6 months (n=117) and 55.6%, 19.4%, 26.4% and 58.3% at 12 months (n=72), respectively. Proteinuria, daily prednisone dosage and Systemic Lupus Erythematosus Disease Activity Index 2000 scores significantly decreased at 6 and 12 months (p<0.0001). NRR at 6 months (NRR6) was the strongest negative predictor of CRR at 12 months. Baseline anti-dsDNA positivity inversely predicted NRR6 (OR=0.32,95% CI=0.10 to 0.98, p=0.049), while anti-SSA/Ro60 positively predicted NRR6 (OR=3.16, 95% CI=1.14 to 8.74, p=0.027). The combination of anti-SSA/Ro60 and anti-dsDNA serotype quantitatively predicted belimumab renal response. Conclusion The effectiveness of belimumab was reproducible in Chinese patients with active LN. The simple yet interesting serotype predictive model needs further validation and its possible underlying mechanistic relevance deserves further exploration.
资助项目	Clinical Research Plan of Shanghai Hospital Development Center [SHDC2020CR1015B, SHDC2024CRI019]; Renji Hospital, School of Medicine, Shanghai Jiaotong University [2019NYLYCP0202]; Key Research and Development Project of Xinjiang Uygur Autonomous Region [2022B03002-1]
出版者	BMJ PUBLISHING GROUP
ISSN	2053-8790
卷号	11 期号:1
DOI	10.1136/lupus-2024-001156
页数	8
WOS类目	Rheumatology
WOS研究方向	Rheumatology
WOS记录号	WOS:001236382400001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38806217
SCOPUSEID	2-s2.0-85195051447
通讯作者地址	[Ye, Shuang]Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Rheumatol, Shanghai, Peoples R China. ; [Zhu, Jing]Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Sch Med, Chengdu, Peoples R China. ; [Sun, Li]Wenzhou Med Univ, Affiliated Hosp 1, Dept Rheumatol, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类	Rheumatology;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214593
专题	附属第一医院_风湿免疫科
通讯作者	Zhu, Jing; Sun, Li; Ye, Shuang
作者单位	1.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Dept Rheumatol, Shanghai, Peoples R China; 2.Zhejiang Univ, Affiliated Hosp 2, Dept Rheumatol, Sch Med, Hangzhou, Zhejiang, Peoples R China; 3.Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rheumatology&Immunol, Urumqi, Xinjiang, Peoples R China; 4.Xinjiang Clin Res Ctr Rheumatoid Arthrit, Urumqi, Xinjiang, Peoples R China; 5.Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Sch Med, Chengdu, Peoples R China; 6.Wenzhou Med Univ, Affiliated Hosp 1, Dept Rheumatol, Wenzhou, Zhejiang, Peoples R China; 7.Shanghai Jiao Tong Univ, Sch Med, Ren Ji Hosp, Shanghai Inst Rheumatol, Shanghai 200030, Peoples R China
通讯作者单位	附属第一医院_风湿免疫科
推荐引用方式 GB/T 7714	Zhao, Liling,Wang, Wenwen,Wu, Lijun,et al. Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis[J]. LUPUS SCIENCE & MEDICINE,2024,11(1).
APA	Zhao, Liling., Wang, Wenwen., Wu, Lijun., Wu, Tong., Tu, Jianxin., ... & Ye, Shuang. (2024). Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis. LUPUS SCIENCE & MEDICINE, 11(1).
MLA	Zhao, Liling,et al."Combination of anti-SSA/Ro60 and anti-dsDNA serotype is predictive of belimumab renal response in patients with lupus nephritis".LUPUS SCIENCE & MEDICINE 11.1(2024).