The role of endogenous neural stem cells in stroke

doi:10.1007/978-3-319-11481-1_3

科研成果详情

题名	The role of endogenous neural stem cells in stroke
作者	ZhuGe, Qichuan1,3; Ruan, Linhui1,2; Jin, Kunlin1,2
来源专著	Cellular Therapy for Stroke and CNS Injuries
语种	英语
原始文献类型	Book Chapter
关键词	Endogenous neural stem cells Functional integration Migration Proliferation Stroke
摘要	Stroke is the 4th leading cause of death and the leading cause of severe long-term disability worldwide, with no effective treatment for most cases. The development of new effective therapies is needed to improve functional neurological recovery in stroke patients. Researches in experimental stroke in animal models over the past decade demonstrate that ischemic stroke enhances endogenous neural stem cells proliferation in SVZ and SGZ and promotes SVZ NSCs migration to the ischemic infarct site, differentiation into functional mature neurons. Ischemic injury triggers endogenous neural stem cell proliferation by a variety of growth factors, morphogens and neurotransmitters. Neuroblast migration occurs through SDF-1, MCP-1, MMP production and through association with vasculature and endothelial cells. These promising findings in stroke have brought hope to the development of neurorestorative therapy which aims to enhance endogenous neurogenesis after ischemic stroke and thereby contribute to the functional recovery.
出版者	Springer International Publishing
ISBN	[{$=9783319114811}, {$=9783319114804}]
页码	33-46
DOI	10.1007/978-3-319-11481-1_3
收录类别	SCOPUS
出版日期	2015
URL	查看原文
Scopus记录号	2-s2.0-84944202357
Scopus学科分类	Medicine (all);Neuroscience (all);Biochemistry, Genetics and Molecular Biology (all)
通讯作者地址	[Jin, Kunlin]Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University,Wenzhou,China
引用统计
文献类型	专著章节
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214569
专题	附属第一医院附属第一医院_神经外科
通讯作者	Jin, Kunlin
作者单位	1.Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, First Affiliated Hospital, Wenzhou Medical University,Wenzhou,China; 2.Department of Pharmacology and Neuroscience, University of North Texas Health Science Center,3500 Camp Bowie Blvd,Fort Worth,76107,United States; 3.Department of Neurosurgery, The First Affiliated Hospital, Wenzhou Medical University,Wenzhou,China
第一作者单位	附属第一医院; 附属第一医院_神经外科
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	ZhuGe, Qichuan,Ruan, Linhui,Jin, Kunlin. The role of endogenous neural stem cells in stroke:Springer International Publishing,2015:33-46.