Circadian clock control of hepatic lipid metabolism: Role of small heterodimer partner (Shp)

doi:10.1136/jim-2016-000194

科研成果详情

题名	Circadian clock control of hepatic lipid metabolism: Role of small heterodimer partner (Shp)
作者	Wang, Li 1,2,3,4; Liangpunsakul, Suthat 5,6,7
发表日期	2016-10
会议录名称	Journal of Investigative Medicine 影响因子和分区
语种	英语
原始文献类型	Conference Paper
关键词	Lipid Metabolism
摘要	Hepatic steatosis, the accumulation of triglyceride droplets in the hepatocytes, is a common hepatic pathology seen in subjects with obesity/metabolic syndrome and those with excessive alcohol use. The pathogenesis underlying hepatic steatosis is complex. Recent studies have shown the specific role played by the molecular clock mechanism in the control of lipid metabolism and that the disruption of these tissue clocks may lead to the disturbances in lipid homeostasis. This review reports a novel role of small heterodimer partner in maintaining triglyceride and lipoprotein homeostasis through neuronal PAS domain protein 2.
资助项目	NIH[1I01CX000361,P30 DK34989,R01 DK107682,R01DK080440,R01DK104656,R01ES025909,R21AA022482,R21CA191507,U01AA021840];DOD[R21AA024935-01,W81XWH-12-1-0497];VA[1I01BX002634]
出版者	BMJ Publishing Groupsubscriptions@bmjgroup.com
ISSN	1081-5589
EISSN	1708-8267
卷号	64
期号	7
页码	1158-1161
DOI	10.1136/jim-2016-000194
收录类别	SCOPUS
URL	查看原文
Pubmed记录号	27473715
Scopus记录号	2-s2.0-85022100889
通讯作者地址	[Liangpunsakul, Suthat]Division of Gastroenterology and Hepatology,Department of Medicine,Indiana University School of Medicine,550 N. University Blvd, UH 4100,Indianapolis,46202,United States
Scopus学科分类	Biochemistry, Genetics and Molecular Biology (all)
引用统计
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214567
专题	药学院（分析测试中心）
通讯作者	Liangpunsakul, Suthat
作者单位	1.Department of Physiology and Neurobiology,University of Connecticut,Storrs,United States; 2.Veterans Affairs Connecticut Healthcare System,West Haven,United States; 3.Department of Internal Medicine,Section of Digestive Diseases,Yale University,New Haven,United States; 4.School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou, Zhejiang,China; 5.Division of Gastroenterology and Hepatology,Department of Medicine,Indiana University School of Medicine,550 N. University Blvd, UH 4100,Indianapolis,46202,United States; 6.Roudebush Veterans Administration Medical Center,Indianapolis,United States; 7.Department of Biochemistry and Molecular Biology,Indiana University School of Medicine,Indianapolis,United States
第一作者单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Wang, Li,Liangpunsakul, Suthat. Circadian clock control of hepatic lipid metabolism: Role of small heterodimer partner (Shp)[C]:BMJ Publishing Groupsubscriptions@bmjgroup.com,2016:1158-1161.