The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: Therapeutic effects by chelators

doi:10.1080/03630260701727077

科研成果详情

题名	The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: Therapeutic effects by chelators
作者	Zheng, Yang 1; Li, Xiao-Kun2; Wang, Yuehui 2,3; Cai, Lu2,3,4
发表日期	2008
会议录名称	Hemoglobin 影响因子和分区
语种	英语
原始文献类型	Conference Paper
关键词	Chelation therapy Diabetes Diabetic complications Insulin resistance Trace elements
摘要	Zinc (Zn), copper (Cu) and iron (Fe) are essential minerals that are required for a variety of biomolecules to maintain the normal structure, function, and proliferation of cells. These metals can be toxic in excessive amounts, especially in certain genetic disorders. The homeostasis of these trace elements results from a tightly coordinated regulation by different proteins involved in their uptake, excretion and intracellular storage/trafficking. Through the Fenton reaction, Cu and Fe under a non protein-binding condition, can generate various reactive oxygen species, damaging tissues or cells. Abnormal metabolism of Zn, Cu and Fe can lead to several chronic pathogenesis, such as diabetes or diabetic complications. These pathogenic conditions appear to be prevalent in Zn and Cu deficiency, as well as Cu and Fe overload. In the Fe and Cu overloading conditions, Fe and Cu chelating drugs could be used to control diabetes and diabetic complications. The essentiality, toxicity and roles of these metals in the pathogenesis of diabetes and diabetic complications are discussed. Copyright © Informa Healthcare USA, Inc.
资助项目	Jilin Public Health, Changchun, People’s Republic of China[200705127];American Diabetes Association[02-07-JF-02,05-07-CD-02]
ISSN	1532-432X
EISSN	0363-0269
卷号	32
期号	1-2
页码	135-145
DOI	10.1080/03630260701727077
收录类别	SCOPUS
URL	查看原文
Pubmed记录号	18274991
Scopus记录号	2-s2.0-39349103963
通讯作者地址	[Cai, Lu]Department of Medicine and Radiation Oncology,University of Louisville,MDR 533,511 South Floyd Street,United States
Scopus学科分类	Hematology;Genetics (clinical);Clinical Biochemistry;Biochemistry (medical)
引用统计
文献类型	会议论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214538
专题	药学院（分析测试中心）
通讯作者	Cai, Lu
作者单位	1.Department of Cardiovascular Diseases,Jilin University First Clinical College,China; 2.Chinese-American Research Institute for Diabetic Complications,School of Pharmaceutical Sciences,Wenzhou Medical College,China; 3.Departments of Medicine, Radiation Oncology, and Pharmacology and Toxicology,University of Louisville,United States; 4.Department of Medicine and Radiation Oncology,University of Louisville,MDR 533,511 South Floyd Street,United States
推荐引用方式 GB/T 7714	Zheng, Yang,Li, Xiao-Kun,Wang, Yuehui,et al. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: Therapeutic effects by chelators[C],2008:135-145.