Silk fibroin nanomaterials

doi:10.1016/B978-0-12-824364-0.00016-2

科研成果详情

题名	Silk fibroin nanomaterials
作者	Xu, He-Lin; ZhuGe, De-Li
来源专著	Biopolymeric Nanomaterials: Fundamentals and Applications
语种	英语
原始文献类型	Book Chapter
关键词	Drug delivery Nanofibers Nanomaterials Nanoparticles Nanoshells Silk fibroin Tissue engineering
摘要	Silk fibroin (SF) is the US Food and Drug Administration (FDA) approved natural polymer biomaterial with properties of high biocompatibility, biodegradability, and processability. Recently, many studies used SF as biomaterials for drug delivery and tissue engineering. Due to the high surface to volume ratio, nanomaterials are considered good candidates for the next generation in the field of medicine. In the current chapter, we will focus on SF nanomaterials and their application in biomaterials. In brief, the different types of silk cocoons as well as the general manufacturing protocols of SF, mainly including steps of degumming, dissolving, and purification were introduced. Moreover, the physicochemical properties of SF, especially SF secondary structure, biocompatibility, controllable degradation behavior, and ability of encapsulating drugs, have been summarized. Then, the subtypes of SF-based nanomaterials will be summarized, including nanoparticles (NPs), nanofibers, nanoshells, and nanogels. The medical applications of SF nanomaterials will be also outlined in term of drugs delivery and tissue engineering. The drawbacks of SF nanomaterials in field of medical application will be also discussed. For example, the colloidal stability of SF NPs as drug delivery carriers should be improved. Besides, the biological toxicity of SF nanomaterials will be also included in this chapter. For example, SF nanomaterials have been shown to involve in nuclear factor (NF)-κB signaling pathway. Finally, SF composite materials have been developed to improve the property defects of SF. In summary, SF-based nanomaterials are promising candidates in biological applications.
出版者	Elsevier
ISBN	9780128243640
页码	171-202
DOI	10.1016/B978-0-12-824364-0.00016-2
收录类别	SCOPUS
出版日期	2021
URL	查看原文
Scopus记录号	2-s2.0-85128012460
Scopus学科分类	Engineering (all);Materials Science (all)
引用统计
文献类型	专著章节
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214368
专题	药学院（分析测试中心）
作者单位	Department of Pharmaceutics,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou City,China
第一作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Xu, He-Lin,ZhuGe, De-Li. Silk fibroin nanomaterials:Elsevier,2021:171-202.