Panax notoginseng saponins inhibit pulmonary vascular remodeling in hypoxic pulmonary hypertensive rats via Notch3/Hes-1/p27 Kip1 signaling pathway

doi:10.3969/j.issn.1000-4718.2022.02.003

科研成果详情

题名	Panax notoginseng saponins inhibit pulmonary vascular remodeling in hypoxic pulmonary hypertensive rats via Notch3/Hes-1/p27 Kip1 signaling pathway
其他题名	三七总皂苷通过 Notch3/Hes-1/p27 Kip1 信号通路抑制低氧性肺动脉高压大鼠肺血管重构
作者	Zhang, Sai; Song, Zheng-Yang; Wang, Shu-Yuan; Tian, Yun-Na; Wang, Xiao-Ting; Lin, Qing-Qing; Wang, Wan-Tie
发表日期	2022-02-01
发表期刊	Chinese Journal of Pathophysiology; 影响因子和分区
语种	中文
原始文献类型	Article
关键词	Hypoxia Notch3/Hes-1/p27Kip1 signaling pathway Panax notoginseng saponins Pulmonary hypertension Vascular remodeling
摘要	AIM：To explore the effects of Panax notoginseng saponin（PNS）on hypoxia pulmonary hypertension（HPH）-induced pulmonary vascular remodeling in rats. METHODS：Male SD rats were randomly divided into 3 groups：normoxic control group（C group），hypoxia group（H group）and PNS group（P group）. Mean pulmonary artery pressure，right ventricular hypertrophy index and pulmonary vascular remodeling were detected. The protein levels of Notch3，Hes1，p27Kip1，proliferating cell nuclear antigen（PCNA）and caspase-3 were measured by Western blot. The mRNA expression levels of Notch3，Hes-1 and p27Kip1 were measured by RT-qPCR. RESULTS：Pulmonary hypertension，right rentricular hypertrophy and pulmonary vascular remodeling were observed in HPH model rats，with increased expression of Notch3，Hes-1 and PCNA，and decreased expression of p27Kip1 and caspase-3（P<0. 05）. Furthermore，PNS treatment alleviated pulmonary hypertension and right rentricular hypertrophy，and inhibited hypoxia-induced pulmonary vascular remodeling. Treatment with PNS also inhibited the expresion of Notch3，Hes-1 and PCNA，and stimulated the expresion of p27Kip1 and caspase-3（P<0. 05）. CONCLUSION：Treatment with PNS attenuates HPH pulmonary vascular remodeling in rats by inhibition of Notch3/Hes-1/p27Kip1 signaling pathway.
ISSN	1000-4718
卷号	38 期号:2 页码:209-214
DOI	10.3969/j.issn.1000-4718.2022.02.003
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85168272256
通讯作者地址	[Wang, Wan-Tie]Department of Physiology and Pathophysiology,Wenzhou Medical University,Wenzhou,325035,China
Scopus学科分类	Pathology and Forensic Medicine;Physiology (medical);Medicine (miscellaneous)
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/214098
专题	基础医学院（机能实验教学中心）_病理学与病理生理学系
通讯作者	Wang, Wan-Tie
作者单位	Department of Physiology and Pathophysiology,Wenzhou Medical University,Wenzhou,325035,China
第一作者单位	病理学与病理生理学系
通讯作者单位	病理学与病理生理学系
第一作者的第一单位	病理学与病理生理学系
推荐引用方式 GB/T 7714	Zhang, Sai,Song, Zheng-Yang,Wang, Shu-Yuan,et al. Panax notoginseng saponins inhibit pulmonary vascular remodeling in hypoxic pulmonary hypertensive rats via Notch3/Hes-1/p27 Kip1 signaling pathway[J]. Chinese Journal of Pathophysiology;,2022,38(2):209-214.
APA	Zhang, Sai., Song, Zheng-Yang., Wang, Shu-Yuan., Tian, Yun-Na., Wang, Xiao-Ting., ... & Wang, Wan-Tie. (2022). Panax notoginseng saponins inhibit pulmonary vascular remodeling in hypoxic pulmonary hypertensive rats via Notch3/Hes-1/p27 Kip1 signaling pathway. Chinese Journal of Pathophysiology;, 38(2), 209-214.
MLA	Zhang, Sai,et al."Panax notoginseng saponins inhibit pulmonary vascular remodeling in hypoxic pulmonary hypertensive rats via Notch3/Hes-1/p27 Kip1 signaling pathway".Chinese Journal of Pathophysiology; 38.2(2022):209-214.