Effect of alanine aminotransferase in early pregnancy on neonatal birth weight

doi:10.3760/cma.j.cn311282-20210712-00449

科研成果详情

题名	Effect of alanine aminotransferase in early pregnancy on neonatal birth weight
其他题名	妊娠早期丙氨酸转氨酶水平对新生儿出生体重的影响
作者	Wang, Shanshan; Huang H.; Zheng, Tian; Ni, Lifang; Liu, Yu; Yang, Xinjun
发表日期	2022-01-25
发表期刊	Chinese Journal of Endocrinology and Metabolism; 影响因子和分区
语种	中文
原始文献类型	Article
关键词	Abnormal birth weight Alanine aminotransferase Body mass index Interaction Propensityscore matching
摘要	Objective To investigate the effect of alanine aminotransferase(ALT) level in early pregnancyand its interaction with maternal body mass index (BMI) on neonatal birth weight. Methods Data of full?termsingleton delivery mother?infant pairs from 2014 to 2016 in Wenzhou were collected. The exposure(ALT>40 U / L) andnon?exposure(ALT = 40 U / L) groups were matched using 1 : 4 propensity score matching. Logistic regressionanalysis was used to analyze the relationship between increased ALT level in the first trimester and abnormal birthweight as well as the effect of its interaction with BMI on abnormal birth weight. Results Multivariate analysis showedthat the risks of macrosomia and large for gestational age(LGA) in pregnant women with ALT> 40 U / L were 1.584(95% CI 1.323?1.896) and 1.292(95% CI 1.142?1.461) compared with those with ALT=40 U / L. ALT in the firsttrimester displayed an additive interaction with BMI on the risk of macrosomia [ the relative excess risk due tointeraction(RERI)= 2.032, 95% CI 0.307?3.757, the attributable proportion due to interaction(API)= 0.448, 95%CI 0.221?0.684, the synergy index(S)= 2.348, 95% CI 1.274?4.324]. In addition, there was no interaction betweenALT and BMI on the risk of LGA, and nor did the association of ALT in the first trimester with low birth weight or smallfor gestational age exist. Conclusion ALT > 40 U / L in the first trimester increases the risk of high birth weight, especially in overweight or obese pregnant women in the first trimester. Therefore, it is suggested to strengthen themonitoring of ALT level in obese pregnant women during the first trimester.
ISSN	1000-6699
卷号	38 期号:1 页码:24-29
DOI	10.3760/cma.j.cn311282-20210712-00449
收录类别	SCOPUS
URL	查看原文
SCOPUSEID	2-s2.0-85130552311
通讯作者地址	[Yang, Xinjun]Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213970
专题	公共卫生学院_预防医学系
通讯作者	Yang, Xinjun
作者单位	Department of Preventive Medicine,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	预防医学系; 公共卫生学院
通讯作者单位	预防医学系; 公共卫生学院
第一作者的第一单位	预防医学系
推荐引用方式 GB/T 7714	Wang, Shanshan,Huang H.,Zheng, Tian,et al. Effect of alanine aminotransferase in early pregnancy on neonatal birth weight[J]. Chinese Journal of Endocrinology and Metabolism;,2022,38(1):24-29.
APA	Wang, Shanshan, Huang H., Zheng, Tian, Ni, Lifang, Liu, Yu, & Yang, Xinjun. (2022). Effect of alanine aminotransferase in early pregnancy on neonatal birth weight. Chinese Journal of Endocrinology and Metabolism;, 38(1), 24-29.
MLA	Wang, Shanshan,et al."Effect of alanine aminotransferase in early pregnancy on neonatal birth weight".Chinese Journal of Endocrinology and Metabolism; 38.1(2022):24-29.