Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome

doi:10.4251/wjgo.v16.i5.1833

科研成果详情

题名	Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome
作者	Mu, Fan 1; Hu, Liang-Shuo 1; Xu, Kun 2; Zhao, Zhen 1; Yang, Bai-Cai 3; Wang, Yi-Meng 1; Guo, Kun 1; Shi, Jian-Hua 1; Lv, Yi 1; Wang, Bo 1
发表日期	2024
发表期刊	World Journal of Gastrointestinal Oncology; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Antiviral therapy Hepatectomy Hepatitis B virus Hepatitis B virus-DNA Hepatocellular carcinoma
其他关键词	IMPROVES POSTOPERATIVE SURVIVAL ; HIGH VIRAL LOAD ; CURATIVE RESECTION ; LIVER RESECTION ; RECURRENCE ; DNA ; REACTIVATION ; MANAGEMENT ; LAMIVUDINE ; ENTECAVIR
摘要	BACKGROUND Although the benefits of antiviral therapy for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) have been proven, researchers have not confirmed the differences in patient outcomes between patients who received preoperative antiviral therapy for a period of time (at least 24 wk) and patients who received remedial antiviral therapy just before radical resection for HBV-related HCC. AIM To investigate the efficacy of perioperative remedial antiviral therapy in patients with HBV-related HCC. METHODS A retrospective study of patients who underwent radical resection for HBV-related HCC at the First Affiliated Hospital of Xi’an Jiaotong University from January 2016 to June 2019 was conducted. Considering the history of antiviral therapy, patients were assigned to remedial antiviral therapy and preoperative antiviral therapy groups. RESULTS Kaplan–Meier analysis revealed significant differences in overall survival (P < 0.0001) and disease-free survival (P = 0.035) between the two groups. Multivariate analysis demonstrated that a history of preoperative antiviral treatment was independently related to improved survival (hazard ratio = 0.27; 95% confidence interval: 0.08-0.88; P = 0.030). CONCLUSION In patients with HBV-related HCC, it is ideal to receive preoperative long-term antiviral therapy, which helps patients tolerate more extensive hepatectomy; however, remedial antiviral therapy, which reduces preoperative HBV-DNA levels to less than 4 Log10 copies DNA/mL, can also result in improved outcomes.
资助项目	National Natural Science Foundation of China[82070649];
出版者	BAISHIDENG PUBLISHING GROUP INC
ISSN	1948-5204
卷号	16 期号:5 页码:1833-1848
DOI	10.4251/wjgo.v16.i5.1833
页数	17
WOS类目	Oncology ; Gastroenterology & Hepatology
WOS研究方向	Oncology ; Gastroenterology & Hepatology
WOS记录号	WOS:001233475700014
收录类别	SCOPUS ; SCIE ; PUBMED
URL	查看原文
PubMed ID	38764825
SCOPUSEID	2-s2.0-85193737298
通讯作者地址	[Wang, Bo]Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi’an Jiaotong University,No. 277 Yanta Road, Shaanxi Province,Xi’an,710061,China
Scopus学科分类	Oncology;Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213389
专题	温州医科大学
通讯作者	Wang, Bo
作者单位	1.Department of Hepatobiliary Surgery,First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Province,Xi’an,710061,China; 2.Department of Anaesthesiology,First Affiliated Hospital of Xi’an Jiaotong University,Shaanxi Province,Xi’an,710061,China; 3.Department of Gynaecology,Wenzhou Medical University Affiliated Jiaxing Women and Children Hospital,Zhejiang Province,Jiaxing,314000,China
推荐引用方式 GB/T 7714	Mu, Fan,Hu, Liang-Shuo,Xu, Kun,et al. Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome[J]. World Journal of Gastrointestinal Oncology;,2024,16(5):1833-1848.
APA	Mu, Fan., Hu, Liang-Shuo., Xu, Kun., Zhao, Zhen., Yang, Bai-Cai., ... & Wang, Bo. (2024). Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome. World Journal of Gastrointestinal Oncology;, 16(5), 1833-1848.
MLA	Mu, Fan,et al."Perioperative remedial antiviral therapy in hepatitis B virus-related hepatocellular carcinoma resection: How to achieve a better outcome".World Journal of Gastrointestinal Oncology; 16.5(2024):1833-1848.