科研成果详情

题名Adipose mesenchymal stem cells-derived exosomes attenuated hyperoxia-induced lung injury in neonatal rats via inhibiting the NF-κB signaling pathway
作者
发表日期2024
发表期刊Pediatric Pulmonology;   影响因子和分区
语种英语
原始文献类型Article
关键词adipose mesenchymal stem cells bronchopulmonary dysplasia exosomes hyperoxia NF-κB
其他关键词OUTCOMES ; INFANTS
摘要Objective: Bronchopulmonary dysplasia (BPD) is the most common chronic morbidity in extremely preterm infants. Mesenchymal stem cells-derived exosomes (MSC-Exos) therapies have shown prospects in animal models of BPD. Our study aimed to evaluate the effect of adipose mesenchymal stem cells-derived exosomes (AMSC-Exos) on BPD and the role of the NF-κB signaling pathway in this process. Methods: The AMSCs were extracted and AMSC-Exos were isolated by ultracentrifugation method. Newborn rats were exposed to hyperoxia (90% O2) continuously for 7 days to establish a BPD model. The rats were treated with AMSC-Exos by intratracheal administration on postnatal day 4 (P4). Pulmonary morphology, pulmonary vasculature, inflammatory factors, and NF-κB were assessed. Hyperoxia-induced primary type II alveolar epithelial cells (AECIIs) and AMSC-Exos treatment with or without a pan-NF-κB inhibitor (PDTC) were established to explore the potential mechanism. Results: Hyperoxia-exposed rats showed alveolar simplification with decreased radial alveolar count and increased mean linear intercept, low CD31, and vascular endothelial growth factor expression, reduced microvessel density, increased the expression of TNF-α, IL-1β, and IL-6 and decreased the expression of IL-10, and induced NF-κB phosphorylation. AMSC-Exos protected the neonatal lung from the hyperoxia-induced arrest of alveolar and vascular development, alleviated inflammation, and inhibited NF-κB phosphorylation. Hyperoxia decreased viability, increased apoptosis, enhanced inflammation, and induced NF-κB phosphorylation of AECIIs but improved by AMSC-Exos, PDTC, or AMSC-Exos+PDTC. The effect of AMSC-Exos+PDTC in AECIIs was the same as AMSC-Exos, but more notable than PDTC alone. Conclusion: AMSC-Exos attenuated the hyperoxia-induced lung injury in neonatal rats by inhibiting the NF-κB signaling pathway partly.
资助项目Basic Public Welfare Research Program of Zhejiang, China[LGF21H040002];Wenzhou Science and Technology Research Project, Zhejiang, China[Y2023003,LTGY23H040001];
出版者WILEY
ISSN8755-6863
EISSN1099-0496
DOI10.1002/ppul.27057
页数12
WOS类目Pediatrics ; Respiratory System
WOS研究方向Pediatrics ; Respiratory System
WOS记录号WOS:001227919500001
收录类别SCOPUS ; SCIE ; PUBMED
URL查看原文
PubMed ID38771197
SCOPUSEID2-s2.0-85193577312
通讯作者地址[Sun, Yuanyuan]Department of Pediatrics,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类Pediatrics, Perinatology and Child Health;Pulmonary and Respiratory Medicine
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/213373
专题附属第一医院
其他_温州医科大学附属衢州医院
通讯作者Sun, Yuanyuan
作者单位
1.Department of Pediatrics,Yiwu Maternity and Children Hospital,Zhejiang,Jinhua,China;
2.Department of Prenatal Diagnostic Center,Yiwu Maternity and Children Hospital,Zhejiang,Jinhua,China;
3.Department of Anesthesiology,Women's Hospital School of Medicine Zhejiang University,Zhejiang,Hangzhou,China;
4.Department of Pediatrics,Yuhuan People's Hospital,Zhejiang,Taizhou,China;
5.Department of Pediatrics,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China;
6.Department of Pediatrics,The Quzhou Affiliated Hospital of Wenzhou Medical University (Quzhou People's Hospital),Zhejiang,Quzhou,China
通讯作者单位附属第一医院;  第一临床医学院(信息与工程学院)、附属第一医院
推荐引用方式
GB/T 7714
Chen, Cuie,Jin, Yuxia,Jin, Hongxing,et al. Adipose mesenchymal stem cells-derived exosomes attenuated hyperoxia-induced lung injury in neonatal rats via inhibiting the NF-κB signaling pathway[J]. Pediatric Pulmonology;,2024.
APA Chen, Cuie., Jin, Yuxia., Jin, Hongxing., Chen, Shujun., Wang, Lu., ... & Sun, Yuanyuan. (2024). Adipose mesenchymal stem cells-derived exosomes attenuated hyperoxia-induced lung injury in neonatal rats via inhibiting the NF-κB signaling pathway. Pediatric Pulmonology;.
MLA Chen, Cuie,et al."Adipose mesenchymal stem cells-derived exosomes attenuated hyperoxia-induced lung injury in neonatal rats via inhibiting the NF-κB signaling pathway".Pediatric Pulmonology; (2024).

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