Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy

doi:10.1002/SMMD.20230016

科研成果详情

题名	Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy
作者	Liang, Danna1,2; Kuang, Gaizhen 3; Chen, Xiang 1,2; Lu, Jianhua1,2; Shang, Luoran 1,2,3,4,5; Sun, Weijian1,2
发表日期	2023-08
发表期刊	SMART MEDICINE 影响因子和分区
语种	英语
原始文献类型	Article
关键词	gas therapy microcarriers microfluidic electrospray multimodal tumor therapy nitric oxide
摘要	Nitric oxide (NO) has shown great potential in tumor therapy, and the development of a platform for precise and controllable NO release still needs to be explored. Herein, a microfluidic electrospray strategy is proposed for the fabrication of hydrogel microspheres encapsulating NO donors (S-nitrosoglutathione, GSNO) together with black phosphorus (BP) and chemotherapeutic doxorubicin (DOX) as microcarriers for tumor therapy. Based on the excellent photothermal property of BP and thermal sensitivity of GSNO, the microcarriers exhibit a near-infrared light (NIR)-responsive NO release behavior. Besides, the photothermal performance of the microcarriers accelerates the release of DOX. All these contribute to the excellent tumor-killing effect of the microcarriers by combining multiple therapeutic strategies including NO therapy, photothermal therapy, and chemotherapy. Moreover, it was demonstrated that the NIR-responsive NO delivery microcarriers could significantly inhibit tumor growth without apparent side effects in vivo. Therefore, it is believed that the novel NIR-responsive NO microcarriers are promising candidates in clinical tumor therapy applications.
资助项目	National Natural Science Foundation of China [81972261]
出版者	WILEY
ISSN	2751-1871
卷号	2 期号:3
DOI	10.1002/SMMD.20230016
页数	10
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001207739800004
收录类别	ESCI
通讯作者地址	[Shang, Luoran;Sun, Weijian]Wenzhou Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Wenzhou 325027, Zhejiang, Peoples R China.;Sun, Weijian]Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China. ; [Shang, Luoran]Fudan Univ, Zhongshan Xuhui Hosp, Inst Biomed Sci, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Zhongshan 200032, Shanghai, Peoples R China. ; [Shang, Luoran]Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213201
专题	附属第二医院_胃肠外科第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Shang, Luoran; Sun, Weijian
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Wenzhou 325027, Zhejiang, Peoples R China; 2.Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou 325027, Zhejiang, Peoples R China; 3.Univ Chinese Acad Sci, Wenzhou Inst, Oujiang Lab, Zhejiang Lab Regenerat Med Vis & Brain Hlth, Wenzhou, Zhejiang, Peoples R China; 4.Fudan Univ, Zhongshan Xuhui Hosp, Inst Biomed Sci, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Zhongshan 200032, Shanghai, Peoples R China; 5.Fudan Univ, Inst Biomed Sci, Shanghai Key Lab Med Epigenet, Int Colab Med Epigenet & Metab,Minist Sci & Techno, Shanghai 200032, Peoples R China
第一作者单位	附属第二医院_胃肠外科; 第二临床医学院，附属第二医院、育英儿童医院
通讯作者单位	附属第二医院_胃肠外科
第一作者的第一单位	附属第二医院_胃肠外科
推荐引用方式 GB/T 7714	Liang, Danna,Kuang, Gaizhen,Chen, Xiang,et al. Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy[J]. SMART MEDICINE,2023,2(3).
APA	Liang, Danna, Kuang, Gaizhen, Chen, Xiang, Lu, Jianhua, Shang, Luoran, & Sun, Weijian. (2023). Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy. SMART MEDICINE, 2(3).
MLA	Liang, Danna,et al."Near-infrared light-responsive Nitric oxide microcarrier for multimodal tumor therapy".SMART MEDICINE 2.3(2023).