Microglia lactylation in relation to central nervous system diseases

doi:10.4103/NRR.NRR-D-23-00805

科研成果详情

题名	Microglia lactylation in relation to central nervous system diseases
作者	Yang, Hui 1; Mo, Nan 2; Tong, Le 3; Dong, Jianhong 1; Fan, Ziwei4; Jia, Mengxian4; Yue, Juanqing 5; Wang, Ying 6
发表日期	2025-01
发表期刊	NEURAL REGENERATION RESEARCH 影响因子和分区
语种	英语
原始文献类型	Review
关键词	brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases
其他关键词	LACTATE TRANSPORT ; LACTIC-ACID ; BRAIN ; EXPRESSION ; METABOLISM ; RECEPTOR ; NEURONS ; CELLS
摘要	The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response, and neurodegenerative diseases. Lactate has been considered a metabolic waste product, but recent studies are revealing ever more of the physiological functions of lactate. Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions, macrophage polarization, neuromodulation, and angiogenesis and has also been implicated in the development of various diseases. This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation, histone versus non-histone lactylation, and therapeutic approaches targeting lactate. Finally, we summarize the current research on microglia lactylation in central nervous system diseases. A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.
出版者	WOLTERS KLUWER MEDKNOW PUBLICATIONS
ISSN	1673-5374
EISSN	1876-7958
卷号	20 期号:1 页码:29-40
DOI	10.4103/NRR.NRR-D-23-00805
页数	12
WOS类目	Cell Biology ; Neurosciences
WOS研究方向	Cell Biology ; Neurosciences & Neurology
WOS记录号	WOS:001220747500001
收录类别	SCIE ; PUBMED
URL	查看原文
Pubmed记录号	38767474
通讯作者地址	[Yue, Juanqing]Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China. ; [Wang, Ying]Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Clin Res Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China.
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/213200
专题	附属第一医院
通讯作者	Yue, Juanqing; Wang, Ying
作者单位	1.Hangzhou Normal Univ, Sch Pharm, Hangzhou, Zhejiang, Peoples R China; 2.Zhejiang Univ Tradit Chinese Med, Hangzhou Peoples Hosp 1, Clin Med Coll 4, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China; 3.Univ Glasgow, Coll Med Vet & Life Sci, Glasgow, Scotland; 4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthoped Spine Surg, Wenzhou, Zhejiang, Peoples R China; 5.Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China; 6.Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Clin Res Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China
推荐引用方式 GB/T 7714	Yang, Hui,Mo, Nan,Tong, Le,et al. Microglia lactylation in relation to central nervous system diseases[J]. NEURAL REGENERATION RESEARCH,2025,20(1):29-40.
APA	Yang, Hui., Mo, Nan., Tong, Le., Dong, Jianhong., Fan, Ziwei., ... & Wang, Ying. (2025). Microglia lactylation in relation to central nervous system diseases. NEURAL REGENERATION RESEARCH, 20(1), 29-40.
MLA	Yang, Hui,et al."Microglia lactylation in relation to central nervous system diseases".NEURAL REGENERATION RESEARCH 20.1(2025):29-40.