Details of Research Outputs

TitleMicroglia lactylation in relation to central nervous system diseases
Creator
Date Issued2025-01
Source PublicationNEURAL REGENERATION RESEARCH   Impact Factor & Quartile
language英语
Original Document TypeReview
Keywordbrain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases
WOS KeywordLACTATE TRANSPORT ; LACTIC-ACID ; BRAIN ; EXPRESSION ; METABOLISM ; RECEPTOR ; NEURONS ; CELLS
AbstractThe development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis. Microglia, as innate immune cells, play important roles in the maintenance of central nervous system homeostasis, injury response, and neurodegenerative diseases. Lactate has been considered a metabolic waste product, but recent studies are revealing ever more of the physiological functions of lactate. Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions, macrophage polarization, neuromodulation, and angiogenesis and has also been implicated in the development of various diseases. This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation, histone versus non-histone lactylation, and therapeutic approaches targeting lactate. Finally, we summarize the current research on microglia lactylation in central nervous system diseases. A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.
PublisherWOLTERS KLUWER MEDKNOW PUBLICATIONS
ISSN1673-5374
EISSN1876-7958
Volume20Issue:1Pages:29-40
DOI10.4103/NRR.NRR-D-23-00805
Page Number12
WOS SubjectCell Biology ; Neurosciences
WOS Research AreaCell Biology ; Neurosciences & Neurology
WOS IDWOS:001220747500001
Indexed BySCIE ; PUBMED
URL查看原文
PubmedId38767474
Corresponding author address[Yue, Juanqing]Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China. ; [Wang, Ying]Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Clin Res Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China.
Citation statistics
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/213200
CollectionWenzhou Medical University First Affiliated Hospital
Corresponding AuthorYue, Juanqing; Wang, Ying
Affiliation
1.Hangzhou Normal Univ, Sch Pharm, Hangzhou, Zhejiang, Peoples R China;
2.Zhejiang Univ Tradit Chinese Med, Hangzhou Peoples Hosp 1, Clin Med Coll 4, Dept Clin Lab, Hangzhou, Zhejiang, Peoples R China;
3.Univ Glasgow, Coll Med Vet & Life Sci, Glasgow, Scotland;
4.Wenzhou Med Univ, Affiliated Hosp 1, Dept Orthoped Spine Surg, Wenzhou, Zhejiang, Peoples R China;
5.Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Sch Med, Dept Pathol, Hangzhou, Zhejiang, Peoples R China;
6.Westlake Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Clin Res Ctr, Sch Med, Hangzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Yang, Hui,Mo, Nan,Tong, Le,et al. Microglia lactylation in relation to central nervous system diseases[J]. NEURAL REGENERATION RESEARCH,2025,20(1):29-40.
APA Yang, Hui., Mo, Nan., Tong, Le., Dong, Jianhong., Fan, Ziwei., ... & Wang, Ying. (2025). Microglia lactylation in relation to central nervous system diseases. NEURAL REGENERATION RESEARCH, 20(1), 29-40.
MLA Yang, Hui,et al."Microglia lactylation in relation to central nervous system diseases".NEURAL REGENERATION RESEARCH 20.1(2025):29-40.

Files in This Item:

There are no files associated with this item.
Related Services
Usage statistics
Google Scholar
Similar articles in Google Scholar
[Yang, Hui]'s Articles
[Mo, Nan]'s Articles
[Tong, Le]'s Articles
Baidu academic
Similar articles in Baidu academic
[Yang, Hui]'s Articles
[Mo, Nan]'s Articles
[Tong, Le]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Yang, Hui]'s Articles
[Mo, Nan]'s Articles
[Tong, Le]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.