Case Report: A Rare Case of Iodixanol-Induced Anaphylactic Shock in Cerebral Angiography

doi:10.2147/JAA.S460263

科研成果详情

名称	Case Report: A Rare Case of Iodixanol-Induced Anaphylactic Shock in Cerebral Angiography
作者	Yang Zhao 1; Hua Wang2; Zhengjun Wu 1; Yunxiang Zhu 1; Jingsong Wang 1
发表期刊	Journal of asthma and allergy
语种	英语
原始文献类型	Case Reports
关键词	anaphylactic shock cerebral angiography hypersensitivity reaction iodixanol
摘要	Adverse reactions induced by isoosmolar contrast medium (iodixanol) are mostly mild, with rashes and headaches being the most common. Although anaphylactic shock has been reported, no related incidents have been documented on cerebral angiography., This article reports a serious case of anaphylactic shock possibly induced by iodixanol and provides an overview of the case report., A 65-year-old female with persistent headaches for nearly six months and CTA examination revealed multiple intracranial aneurysms. After two treatments, she returned to the hospital for aneurysm of reexamination a month ago. Following a preoperative assessment, cerebral angiography was performed. Three minutes after the procedure, the patient experienced dizziness, increased heart rate, followed by hypotension (BP 90/43 mm Hg), a sudden drop-in heart rate (HR 68 bpm), and a drop in SpO2 to 92%. Intravenous dexamethasone for anti-allergic were administered immediately, along with therapy through oxygen-inhalation. However, the patient then developed limb convulsions, unresponsiveness, and was urgently given diazepam for sedation and sputum aspiration to maintain airway patency. Blood pressure decrease to 53/29 mm Hg, and SpO2 readings were unavailable. Intravenous dopamine to elevates blood pressure, and assists breathing by intubating in the endotracheal. After 3 minutes, as the blood pressure remained undetectable, intermittent intravenous epinephrine 1mg was administered to raise the blood pressure, gradually restoring it to 126/90 mm Hg, and SpO2 increased to 95%. The patient was diagnosed with iodixanol-induced anaphylactic shock and urgently transferred to the NICU for monitoring and treatment. The patient died despite immediate treatment., A 65-year-old female developed serious anaphylactic shock during cerebral angiography after receiving iodixanol. Although iodixanol is considered one of the safest iodinated contrast mediums (ICM), clinicians should be aware of its the potential for serious hypersensitivity reactions that can lead to fatal and life-threatening events.
ISSN	1178-6965
卷号	17
DOI	10.2147/JAA.S460263
收录类别	PUBMED
发布日期	2024
URL	查看原文
PubMed ID	38623449
引用统计
文献类型	其他
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212941
专题	附属第一医院_神经外科
作者单位	1.Department of Pharmacy, Guangyuan Central Hospital, Guangyuan, Sichuan, People's Republic of China.; 2.Department of Neurosurgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People's Republic of China.
推荐引用方式 GB/T 7714	Yang Zhao,Hua Wang,Zhengjun Wu,et al. Case Report: A Rare Case of Iodixanol-Induced Anaphylactic Shock in Cerebral Angiography. 2024.