Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway

doi:10.1016/j.intimp.2024.112257

科研成果详情

题名	Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway
作者	Feng, Xiaoli1,2; Zheng, Yihui1,2; Mao, Niping1,2; Shen, Ming1,2; Chu, Liuxi4,5; Fang, Yu1,2; Pang, Mengdan1,2; Wang, Zhouguang 4; Lin, Zhenlang1,2,3
发表日期	2024-05-16
发表期刊	International immunopharmacology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Hypoxic-ischemic encephalopathy Menaquinone-4 Mitochondrial dysfunction Sirt1
其他关键词	VITAMIN-K ; METABOLISM ; SIRT1
摘要	Hypoxic-ischemic encephalopathy (HIE) is a major contributor to neonatal mortality and neurodevelopmental disorders, but currently there is no effective therapy drug for HIE. Mitochondrial dysfunction plays a pivotal role in hypoxic-ischemic brain damage(HIBD). Menaquinone-4 (MK-4), a subtype of vitamin K2 prevalent in the brain, has been shown to enhance mitochondrial function and exhibit protective effects against ischemia-reperfusion injury. However, the impact and underlying molecular mechanism of MK-4 in HIE have not been fully elucidated., In this study, we established the neonatal rats HIBD model in vivo and oxygen-glucose deprivation and reperfusion (OGD/R) of primary neurons in vitro to explore the neuroprotective effects of MK-4 on HI damage, and illuminate the potential mechanism., Our findings revealed that MK-4 ameliorated mitochondrial dysfunction, reduced oxidative stress, and prevented HI-induced neuronal apoptosis by activating the Sirt1-PGC-1α-TFAM signaling pathway through Sirt1 mediation. Importantly, these protective effects were partially reversed by EX-527, a Sirt1 inhibitor., Our study elucidated the potential therapeutic mechanism of MK-4 in neonatal HIE, suggesting its viability as an agent for enhancing recovery from HI-induced cerebral damage in newborns. Further exploration into MK-4 could lead to novel interventions for HIE therapy.
资助项目	National Natural Science Foundation of China[82271747];Wu Jieping Medical Foundation[320.6750.2023-24-2];
出版者	Elsevier B.V.
ISSN	1567-5769
EISSN	1878-1705
卷号	134
DOI	10.1016/j.intimp.2024.112257
页数	14
WOS类目	Immunology ; Pharmacology & Pharmacy
WOS研究方向	Immunology ; Pharmacology & Pharmacy
WOS记录号	WOS:001280520400001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38759366
SCOPUSEID	2-s2.0-85193069967
通讯作者地址	[Wang, Zhouguang]Department of Neonatology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Immunology and Allergy;Immunology;Pharmacology
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212905
专题	第二临床医学院、附属第二医院、育英儿童医院药学院（分析测试中心）附属第二医院其他_附属慈溪医院（慈溪市人民医院）
通讯作者	Wang, Zhouguang; Lin, Zhenlang
作者单位	1.Department of Neonatology,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,325027,China; 2.Key Laboratory of Perinatal Medicine of Wenzhou,Zhejiang,Wenzhou,325027,China; 3.Key Laboratory of Structural Malformations in Children of Zhejiang Province,Zhejiang,Wenzhou,325027,China; 4.National Key Laboratory of Macromolecular Drug Development and Manufacturing,School of Pharmaceutical Science,Wenzhou Medical University,Zhejiang,Wenzhou,325035,China; 5.Affiliated Cixi Hospital,Wenzhou Medical University,Zhejiang,Cixi,315300,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Feng, Xiaoli,Zheng, Yihui,Mao, Niping,et al. Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway[J]. International immunopharmacology,2024,134.
APA	Feng, Xiaoli., Zheng, Yihui., Mao, Niping., Shen, Ming., Chu, Liuxi., ... & Lin, Zhenlang. (2024). Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway. International immunopharmacology, 134.
MLA	Feng, Xiaoli,et al."Menaquinone-4 alleviates hypoxic-ischemic brain damage in neonatal rats by reducing mitochondrial dysfunction via Sirt1-PGC-1α-TFAM signaling pathway".International immunopharmacology 134(2024).