科研成果详情

题名An Online Model for Central Lymph Node Metastases in Papillary Thyroid Carcinoma With BRAF V600E Mutation
作者
发表日期2024-04-26
发表期刊American journal of clinical oncology   影响因子和分区
语种英语
原始文献类型Journal Article
关键词BRAF V600E mutation papillary thyroid carcinoma central lymph node metastases nomogram predictive model risk variables
其他关键词RISK-FACTORS ; BRAF(V600E) MUTATION ; SURGICAL-MANAGEMENT ; MICROCARCINOMA ; ASSOCIATION ; PREDICTION ; DISSECTION ; SURVIVAL ; FEATURES
摘要To construct a predictive model to direct the dissection of the central lymph nodes in papillary thyroid cancer (PTC) with BRAF V600E mutation by identifying the risk variables for central lymph node metastases (CLNM)., Data from 466 PTC patients with BRAF V600E mutations underwent thyroid surgery was collected and analyzed retrospectively. For these patients, we conducted univariate and multivariate logistic regression analysis to find risk variables for CLNM. To construct a nomogram, the independent predictors were chosen. The calibration, discrimination, and clinical utility of the predictive model were assessed by training and validation data., CLNM was present in 323/466 PTC patients with BRAF V600E mutations. By using univariate and multivariate logistic regression, we discovered that gender, age, tumor size, multifocality, and pathological subtype were all independent predictors of CLNM in PTC patients with BRAF V600E mutations. A predictive nomogram was created by combining these variables. In both training and validation groups, the nomogram demonstrated great calibration capacities. The training and validation groups' areas under the curve (AUC) were 0.772 (specificity 0.694, sensitivity 0.728, 95% CI: 0.7195-0.8247) and 0.731 (specificity 0.778, sensitivity 0.653, 95% CI: 0.6386-0.8232) respectively. According to the nomogram's decision curve analysis (DCA), the nomogram might be beneficial. As well, an online dynamic calculator was developed to make the application of this nomogram easier in the clinic., An online nomogram model based on the 5 predictors included gender, age, pathological subtype, multifocality, and tumor size was confirmed to predict CLNM and guide the central lymph nodes dissection in PTC patients with BRAF V600E mutations.
资助项目Wenzhou Municipal Science and Technology Bureau Foundation [Y2020739]
出版者LIPPINCOTT WILLIAMS & WILKINS
ISSN0277-3732
EISSN1537-453X
卷号47期号:8页码:383-390
DOI10.1097/COC.0000000000001109
页数8
WOS类目Oncology
WOS研究方向Oncology
WOS记录号WOS:001276246400006
收录类别PUBMED ; SCIE ; SCOPUS
URL查看原文
PubMed ID38664891
SCOPUSEID2-s2.0-85199499321
通讯作者地址[Zhou, Yi-li]Wenzhou Med Univ, Affiliated Hosp 1, Dept Thyroid Surg, Wenzhou, Zhejiang, Peoples R China.
Scopus学科分类Oncology;Cancer Research
引用统计
文献类型期刊论文
条目标识符https://kms.wmu.edu.cn/handle/3ETUA0LF/212820
专题附属第一医院
第一临床医学院(信息与工程学院)、附属第一医院
附属第二医院
附属第一医院_放化疗科
第二临床医学院、附属第二医院、育英儿童医院
作者单位
1.Department of Thyroid Surgery.;
2.Department of Radiotherapy, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province.;
3.Medical and Radiation Oncology, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
通讯作者单位附属第一医院
推荐引用方式
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Hao Chen,Wen-Kai Pan,Si-Yan Ren,et al. An Online Model for Central Lymph Node Metastases in Papillary Thyroid Carcinoma With BRAF V600E Mutation[J]. American journal of clinical oncology,2024,47(8):383-390.
APA Hao Chen, Wen-Kai Pan, Si-Yan Ren, & Yi-Li Zhou. (2024). An Online Model for Central Lymph Node Metastases in Papillary Thyroid Carcinoma With BRAF V600E Mutation. American journal of clinical oncology, 47(8), 383-390.
MLA Hao Chen,et al."An Online Model for Central Lymph Node Metastases in Papillary Thyroid Carcinoma With BRAF V600E Mutation".American journal of clinical oncology 47.8(2024):383-390.

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