Antiadhesive, antibacterial, and anti-inflammatory sandwich-structured ZIF8-containing gauze for enhanced wound healing

doi:10.1016/j.cej.2024.152060

科研成果详情

题名	Antiadhesive, antibacterial, and anti-inflammatory sandwich-structured ZIF8-containing gauze for enhanced wound healing
作者	Wu, Xinghai1; Wang, Cheng 1; Wang, Jia 1; Feng, Yuchen1; Zhu, Yunpeng1; Pan, Yijia1; Yuan, Yifan1; Chen, Chenhui 1; Cao, Junyan1; Lin, Jixing1; Tong, Xian1; Li, Yuncang 2; Wen, Cuie 2; Shen, Xinkun3; Ma, Jianfeng 1
发表日期	2024-07-01
发表期刊	Chemical Engineering Journal; 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Anti-adhesion Antibacterial Gauze Superhydrophobic Zeolite imidazolate framework-8 (ZIF8)
其他关键词	SUPERHYDROPHOBIC MATERIALS ; DRESSINGS ; SKIN
摘要	Medical gauze is commonly used in clinical practice due to its low irritation, flexibility, and permeability. However, conventional gauze frequently lacks adequate antibacterial and anti-adhesion properties, and gauze that is only superhydrophobic or antibacterial seldom meets the full requirements of infected wound treatment. In this work, we report optimal air permeability, water and blood absorption, and biocompatibility, and effective antibacterial properties of a sandwich-structured gauze composed of a superhydrophobic outer layer, a zeolite imidazolate framework-8 (ZIF8) interlayer, and a superhydrophobic inner layer containing blood-drainage channels (denoted SZS gauze). Three ZIF8 interlayers, ZIF8-1, ZIF8-2, and ZIF8-3, were prepared by soaking medical gauze samples in a mixed solution of 50 mL methanol, 50 mL ethanol, and 0.25, 0.50, or 1.00 g zinc acetate before flat drying, and had Zn content of 0.28, 0.34, and 0.46 at.%, respectively, and their corresponding SZS gauze samples are denoted SZS-1, SZS-2, and SZS-3, respectively. Among all gauze samples, the SZS-2 showed the highest cytocompatibility toward L929 cells and effective in vitro antibacterial ability against E. coli and S. aureus. In a rat subcutaneous inflammation model, the SZS-2 showed complete biosafety and the best antibacterial and anti-inflammatory effects against E. coli and S. aureus mixed bacteria among all gauze samples including standard medical gauze and a sandwich-structured gauze with a blank interlayer between two superhydrophobic layers. These findings indicate that the SZS-2 gauze is a promising candidate for advanced wound care, particularly in the management of infected wounds.
资助项目	National Natural Science Foundation of China[82371017,2022C03135];Wenzhou Major Science and Technology Special Project[ZY2023008];Australian Research Council[DP240101131];
出版者	ELSEVIER SCIENCE SA
ISSN	1385-8947
EISSN	1873-3212
卷号	491
DOI	10.1016/j.cej.2024.152060
页数	12
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS研究方向	Engineering
WOS记录号	WOS:001241313100001
收录类别	SCOPUS ; SCIE ; EI
EI入藏号	20242016093881
EI主题词	Zeolites
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9.1 Immunology ; 802.3 Chemical Operations ; 804.2 Inorganic Compounds ; 931.2 Physical Properties of Gases, Liquids and Solids ; 951 Materials Science
URL	查看原文
SCOPUSEID	2-s2.0-85192765211
通讯作者地址	[Tong, Xian]Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Chemistry (all);Environmental Chemistry;Chemical Engineering (all);Industrial and Manufacturing Engineering
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212779
专题	口腔医学院、附属口腔医院口腔医学院、附属口腔医院_口腔医学研究所其他_附属第三医院（瑞安市人民医院）
通讯作者	Tong, Xian; Wen, Cuie; Shen, Xinkun; Ma, Jianfeng
作者单位	1.Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 2.School of Engineering,RMIT University,Melbourne,3001,Australia; 3.Ruian People's Hospital,The Third Affiliated Hospital of Wenzhou Medical University,Wenzhou,325016,China
第一作者单位	口腔医学研究所; 口腔医学院、附属口腔医院
通讯作者单位	口腔医学研究所; 口腔医学院、附属口腔医院
第一作者的第一单位	口腔医学研究所
推荐引用方式 GB/T 7714	Wu, Xinghai,Wang, Cheng,Wang, Jia,et al. Antiadhesive, antibacterial, and anti-inflammatory sandwich-structured ZIF8-containing gauze for enhanced wound healing[J]. Chemical Engineering Journal;,2024,491.
APA	Wu, Xinghai., Wang, Cheng., Wang, Jia., Feng, Yuchen., Zhu, Yunpeng., ... & Ma, Jianfeng. (2024). Antiadhesive, antibacterial, and anti-inflammatory sandwich-structured ZIF8-containing gauze for enhanced wound healing. Chemical Engineering Journal;, 491.
MLA	Wu, Xinghai,et al."Antiadhesive, antibacterial, and anti-inflammatory sandwich-structured ZIF8-containing gauze for enhanced wound healing".Chemical Engineering Journal; 491(2024).