题名 | An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease |
作者 | Zhang, Le1; El-Shabrawi, Mortada2; Baur, Louise A.3,4; Byrne, Christopher D.5,6; Targher, Giovanni7,8; Kehar, Mohit9; Porta, Gilda10; Lee, Way Seah11; Lefere, Sander12,13; Turan, Serap14; Alisi, Anna15; Weiss, Ram16; Faienza, Maria Felicia17; Ashraf, Ambika18; Sundaram, Shikha S.19; Srivastava, Anshu20; De Bruyne, Ruth21; Kang, Yunkoo22; Bacopoulou, Flora23,24; Zhou, Yong-Hai25; Darma, Andy26; Lupsor-Platon, Monica27,28; Hamaguchi, Masahide29; Misra, Anoop30,31,32; Méndez-Sánchez, Nahum33; Ng, Nicholas Beng Hui34,35; Marcus, Claude36; Staiano, Amanda E.37; Waheed, Nadia38; Alqahtani, Saleh A.39,40; Giannini, Cosimo41; Ocama, Ponsiano42; Nguyen, Mindie H.43,44; Arias-Loste, Maria Teresa45; Ahmed, Mohamed Rabea46; Sebastiani, Giada47; Poovorawan, Yong48; Al Mahtab, Mamun49; Pericàs, Juan M.50,51; Reverbel da Silveira, Themis52; Hegyi, Peter53,54,55; Azaz, Amer56; Isa, Hasan M.57; Lertudomphonwanit, Chatmanee58; Farrag, Mona Issa59; Nugud, Ahmed Abd Alwahab59; Du, Hong-Wei60; Qi, Ke-Min61; Mouane, Nezha62; Cheng, Xin-Ran63; Al Lawati, Tawfiq64; Fagundes, Eleonora D.T.65; Ghazinyan, Hasmik66; Hadjipanayis, Adamos67; Fan, Jian-Gao68,69; Gimiga, Nicoleta70,71; Kamal, Naglaa M.2,72; Ștefănescu, Gabriela73; Hong, Li74; Diaconescu, Smaranda75; Li, Ming76; George, Jacob77; Zheng, Ming-Hua78,79,80
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发表日期 | 2024 |
发表期刊 | Med; 影响因子和分区 |
语种 | 英语 |
原始文献类型 | Article |
关键词 | adolescents children consensus MAFLD MASLD metabolic dysfunction-associated fatty liver disease non-alcoholic fatty liver disease Translation to population health |
其他关键词 | CONTROLLED ATTENUATION PARAMETER ; BONE-MINERAL DENSITY ; OBESE ADOLESCENTS ; INSULIN-RESISTANCE ; HEPATIC STEATOSIS ; CONFERS SUSCEPTIBILITY ; CARDIOVASCULAR RISK ; INFANT NUTRITION ; COMMON VARIANT ; GUT MICROBIOTA |
摘要 | Background: Non-alcoholic fatty liver disease (NAFLD) is highly prevalent in children and adolescents, particularly those with obesity. NAFLD is considered a hepatic manifestation of the metabolic syndrome due to its close associations with abdominal obesity, insulin resistance, and atherogenic dyslipidemia. Experts have proposed an alternative terminology, metabolic dysfunction-associated fatty liver disease (MAFLD), to better reflect its pathophysiology. This study aimed to develop consensus statements and recommendations for pediatric MAFLD through collaboration among international experts. Methods: A group of 65 experts from 35 countries and six continents, including pediatricians, hepatologists, and endocrinologists, participated in a consensus development process. The process encompassed various aspects of pediatric MAFLD, including epidemiology, mechanisms, screening, and management. Findings: In round 1, we received 65 surveys from 35 countries and analyzed these results, which informed us that 73.3% of respondents agreed with 20 draft statements while 23.8% agreed somewhat. The mean percentage of agreement or somewhat agreement increased to 80.85% and 15.75%, respectively, in round 2. The final statements covered a wide range of topics related to epidemiology, pathophysiology, and strategies for screening and managing pediatric MAFLD. Conclusions: The consensus statements and recommendations developed by an international expert panel serve to optimize clinical outcomes and improve the quality of life for children and adolescents with MAFLD. These findings emphasize the need for standardized approaches in diagnosing and treating pediatric MAFLD. Funding: This work was funded by the National Natural Science Foundation of China (82070588, 82370577), the National Key R&D Program of China (2023YFA1800801), National High Level Hospital Clinical Research Funding (2022-PUMCH-C-014), the Wuxi Taihu Talent Plan (DJTD202106), and the Medical Key Discipline Program of Wuxi Health Commission (ZDXK2021007). |
资助项目 | National Key R&D Program of China[2023YFA1800801];Top Medical Expert Team of Wuxi Taihu Talent Plan[DJTD202106];National High Level Hospital Clinical Research Funding[2022-PUMCH-C-014];Medical Key Discipline Program of Wuxi Health Commission[ZDXK2021007];National Natural Science Foundation of China[82070588,82370577]; |
出版者 | Cell Press |
ISSN | 2666-6359 |
EISSN | 2666-6340 |
卷号 | 5期号:7页码:797-815.e2 |
DOI | 10.1016/j.medj.2024.03.017 |
页数 | 21 |
WOS类目 | Medicine, Research & Experimental |
WOS研究方向 | Research & Experimental Medicine |
WOS记录号 | WOS:001287682200001 |
收录类别 | SCOPUS ; PUBMED ; ESCI |
URL | 查看原文 |
PubMed ID | 38677287 |
SCOPUSEID | 2-s2.0-85192309800 |
通讯作者地址 | [George, Jacob]Storr Liver Centre,Westmead Institute for Medical Research,Westmead Hospital,University of Sydney,Sydney,Australia ; [Zheng, Ming-Hua]MAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China |
Scopus学科分类 | Medicine (all) |
引用统计 | |
文献类型 | 期刊论文 |
条目标识符 | https://kms.wmu.edu.cn/handle/3ETUA0LF/212745 |
专题 | 第二临床医学院、附属第二医院、育英儿童医院 第一临床医学院(信息与工程学院)、附属第一医院 附属第二医院 附属第一医院 第二临床医学院、附属第二医院、育英儿童医院_儿科学 |
通讯作者 | George, Jacob; Zheng, Ming-Hua |
作者单位 | 1.Department of Paediatrics,Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital),Wuxi,China; 2.Department of Pediatrics and Pediatric Hepatology,Faculty of Medicine,Cairo University,Cairo,Egypt; 3.Children's Hospital Westmead Clinical School,Sydney Medical School,The University of Sydney,Sydney,Australia; 4.Sydney School of Public Health,The University of Sydney,Sydney,Australia; 5.Nutrition and Metabolism,Faculty of Medicine,University of Southampton,Southampton,United Kingdom; 6.National Institute for Health and Care Research Southampton Biomedical Research Centre,University Hospital Southampton,Southampton,United Kingdom; 7.Department of Medicine,University of Verona,Verona,Italy; 8.Metabolic Diseases Research Unit,IRCCS Sacro Cuore - Don Calabria Hospital,Negrar di Valpolicella,Italy; 9.Division of Pediatric Gastroenterology,Hepatology,and Nutrition,Children's Hospital of Eastern Ontario,Department of Pediatrics,Faculty of Medicine,University of Ottawa,Ottawa,Canada; 10.Pediatric Hepatology,Transplant Unit,Hospital Sírio-Libanês,Hospital Municipal Infantil Menino Jesus,Sau Paulo,Brazil; 11.Department of Paediatrics,Faculty of Medicine,University Malaya,Kuala Lumpur,Malaysia; 12.Hepatology Research Unit,Department Internal Medicine and Pediatrics,Ghent University,Ghent,Belgium; 13.Liver Research Center Ghent,Ghent University,Ghent,Belgium; 14.Pediatric Endocrinology and Diabetes,Marmara University School of Medicine,Istanbul,Turkey; 15.Research Unit of Molecular Genetics of Complex Phenotypes,Bambino Gesù Children's Hospital,IRCCS,Rome,Italy; 16.Department of Pediatrics,Ruth Children's Hospital,Rambam Medical Center and the Bruce Rappaport School of Medicine,Technion,Haifa,Israel; 17.Pediatric Unit,Department of Precision and Regenerative Medicine and Ionian Area,University of Bari “Aldo Moro”,Bari,Italy; 18.Division of Pediatric Endocrinology and Diabetes,Department of Pediatrics,University of Alabama at Birmingham,Birmingham,United States; 19.Section of Pediatric Gastroenterology,Hepatology,and Nutrition,Department of Pediatrics,Pediatric Liver Center,Children's Hospital Colorado,University of Colorado School of Medicine and Anschutz Medical Campus,Aurora,United States; 20.Department of Pediatric Gastroenterology,Sanjay Gandhi Postgraduate Institute of Medical Sciences,Lucknow,India; 21.Department of Pediatric Gastroenterology,Hepatology and Nutrition,Ghent University Hospital,Ghent,Belgium; 22.Department of Pediatrics,Yonsei University Wonju College of Medicine,Wonju,South Korea; 23.Center for Adolescent Medicine and UNESCO Chair in Adolescent Health Care,Aghia Sophia Children's Hospital,Medical School,National and Kapodistrian University of Athens,Athens,Greece; 24.University Research Institute of Maternal and Child Health & Precision Medicine,Medical School,National and Kapodistrian University of Athens,Athens,Greece; 25.Department of Pediatrics,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 26.Department of Pediatrics,Faculty of Medicine,Universitas Airlangga,Surabaya,Indonesia; 27.Department of Medical Imaging,“Iuliu Hatieganu” University of Medicine and Pharmacy,Cluj-Napoca,Romania; 28.“Prof. Dr. O. Fodor” Regional Institute of Gastroenterology and Hepatology,Cluj-Napoca,Romania; 29.Department of Endocrinology and Metabolism,Kyoto Prefectural University of Medicine,Graduate School of Medical Science,Kyoto,Japan; 30.Fortis-C-DOC Centre of Excellence for Diabetes,Metabolic Diseases and Endocrinology,New Delhi,India; 31.National Diabetes,Obesity and Cholesterol Foundation (N-DOC),New Delhi,India; 32.Diabetes Foundation,New Delhi,India; 33.Liver Research Unit,Medica Sur Clinic and Foundation and Faculty of Medicine,National Autonomous University of Mexico,Mexico City,Mexico; 34.Department of Paediatrics,Khoo Teck Puat - National University Children's Medical Institute,National University Hospital,Singapore,Singapore; 35.Department of Paediatrics,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,Singapore; 36.Department of Clinical Science,Intervention and Technology,Division of Pediatrics,Karolinska Institutet,Stockholm,Sweden; 37.Pennington Biomedical Research Center,Baton Rouge,United States; 38.Department of Pediatrics,Shaheed Zulfiqar Ali Bhutto Medical University,Pakistan Institute of Medical Sciences,Islamabad,Pakistan; 39.Organ Transplantation Center of Excellence,King Faisal Specialist Hospital & Research Center,Riyadh,Saudi Arabia; 40.Division of Gastroenterology and Hepatology,Johns Hopkins University,Baltimore,United States; 41.Department of Pediatrics,University of Chieti,Chieti,Italy; 42.Department of Internal Medicine,School of Medicine,Makerere University College of Health Sciences,Kampala,Uganda; 43.Division of Gastroenterology and Hepatology,Department of Medicine,Stanford University Medical Center,Palo Alto,United States; 44.Department of Epidemiology and Population Health,Stanford University,Stanford,United States; 45.Hospital Universitario Marqués de Valdecilla,Gastroenterology and Hepatology Department,Clinical and Translational Research in Digestive Diseases,Instituto de Investigación Marqués de Valdecilla (IDIVAL),Santander,Spain; 46.Department of Pediatrics,Jahra Hospital,Kuwait and Department of Pediatrics,National Hepatology and Tropical Medicine Research Institute (NHTMRI),Cairo,Egypt; 47.Division of Gastroenterology and Hepatology and Division of Infectious Diseases,McGill University Health Centre,Montreal,Canada; 48.Centre of Excellence in Clinical Virology,Faculty of Medicine,Chulalongkorn University,Bangkok,Thailand; 49.Department of Hepatology,Bangabandhu Sheikh Mujib Medical University,Dhaka,Shahbag,Bangladesh; 50.Liver Unit,Vall d'Hebron University Hospital,Vall d'Hebron Institute for Research (VHIR),Universitat Autònoma de Barcelona,Barcelona,Spain; 51.Centros de Investigación Biomédica en Red,Enfermedades Hepáticas y Digestivas (CIBERehd),Madrid,Spain; 52.Department of Pediatrics,Faculty of Medicine,Universidade Ciencias da Saude,Porto Alegre,Brazil; 53.Institute for Translational Medicine,Medical School,University of Pécs,Pécs,Hungary; 54.Center for Translational Medicine,Semmelweis University,Budapest,Hungary; 55.Institute of Pancreatic Diseases,Semmelweis University,Budapest,Hungary; 56.Sheikh Khalifa Medical City,Abu Dhabi,United Arab Emirates; 57.Pediatric Department,Salmaniya Medical Complex and Pediatric Department,Arabian Gulf University,Manama,Bahrain; 58.Division of Gastroenterology,Department of Paediatrics,Faculty of Medicine,Ramathibodi Hospital,Mahidol University,Bangkok,Thailand; 59.Department,of Pediatrics and Pediatric Hepatology,Faculty of Medicine,Cairo University,Cairo,Egypt; 60.Department of Paediatrics,First Hospital of Jilin University,Changchun,China; 61.Laboratory of Nutrition and Development,Key Laboratory of Major Diseases in Children,Ministry of Education,Beijing Pediatric Research Institute,Beijing Children's Hospital,Capital Medical University,National Center for Children's Health,Beijing,China; 62.Department of Pediatric Gastroenterology Hepatology and Nutrition,Academic Children's Hospital Ibn Sina,Mohammed V University,Rabat,Morocco; 63.Department of Paediatric Genetics,Endocrinology and Metabolism,Chengdu Women's and Children's Central Hospital,School of Medicine,University of Electronic Science and Technology of China,Chengdu,China; 64.Pediatrics,The Royal Hospital,Muscat,Oman; 65.Department of Pediatrics,Federal University of Minas Gerais,Belo Horizonte,Brazil; 66.Department of Hepatology,Nikomed Medical Center,Yerevan,Armenia; 67.Medical School,European University Cyprus,Nicosia,Cyprus; 68.Department of Gastroenterology,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai,China; 69.Shanghai Key Lab of Pediatric Gastroenterology and Nutrition,Shanghai,China; 70.Clinical Department of Pediatric Gastroenterology,“St. Mary” Emergency Children's Hospital,Iași,Romania; 71.Faculty of Medicine,“Grigore T. Popa” University of Medicine and Pharmacy,Iași,Romania; 72.Pediatric Hepatology and Gastroenterology,Alhada Armed Forces Hospital,Taif,Saudi Arabia; 73.Department of Gastroenterology,“Grigore T. Popa” University of Medicine and Pharmacy,Iași,Romania; 74.Department of Clinical Nutrition,Shanghai Children's Hospital,Shanghai Jiao Tong University,Shanghai,China; 75.Medical-Surgical Department,Faculty of Medicine,University “Titu Maiorescu”,Bucuresti,Romania; 76.Key Laboratory of Endocrinology of National Health Commission,Department of Endocrinology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,China; 77.Storr Liver Centre,Westmead Institute for Medical Research,Westmead Hospital,University of Sydney,Sydney,Australia; 78.MAFLD Research Center,Department of Hepatology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 79.Institute of Hepatology,Wenzhou Medical University,Wenzhou,China; 80.Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province,Wenzhou,China |
通讯作者单位 | 附属第一医院; 第一临床医学院(信息与工程学院)、附属第一医院 |
推荐引用方式 GB/T 7714 | Zhang, Le,El-Shabrawi, Mortada,Baur, Louise A.,et al. An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease[J]. Med;,2024,5(7):797-815.e2. |
APA | Zhang, Le., El-Shabrawi, Mortada., Baur, Louise A.., Byrne, Christopher D.., Targher, Giovanni., ... & Zheng, Ming-Hua. (2024). An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease. Med;, 5(7), 797-815.e2. |
MLA | Zhang, Le,et al."An international multidisciplinary consensus on pediatric metabolic dysfunction-associated fatty liver disease".Med; 5.7(2024):797-815.e2. |
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