Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion

doi:10.1093/rb/rbae028

科研成果详情

题名	Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion
作者	Xia, Yiru 1,2; Zhang, Zhaowenbin3,4,5; Zhou, Kecong 1,2; Lin, Zhikai 1,2; Shu, Rong 1,2; Xu, Yuze 3,4,5; Zeng, Zhen 3,4,5,6; Chang, Jiang 3,4,5; Xie, Yufeng 1,2,7,8
发表日期	2024
发表期刊	Regenerative Biomaterials 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Bacteria Functional materials Hydrogels Infrared devices Pathology Swelling Bioactives Bleedings Bone implant Bone loss Composite hydrogels Condition Hardystonite Implant loosening Peri-implant lesion Thermionic effects
摘要	Peri-implant lesion is a grave condition afflicting numerous indi-viduals with dental implants. It results from persistent periodontal bacteria accumulation causing inflammation around the implant site, which can primarily lead to implant loosening and ultimately the implant loss. Early-stage peri-implant lesions exhibit symptoms akin to gum disease, including swelling, redness and bleeding of the gums surrounding the implant. These signs indicate infection and inflammation of the peri-implant tissues, which may result in bone loss and implant failure. To address this problem, a thermionic strategy was applied by designing a cuprorivaite-hardystonite bioceramic/alginate composite hydrogel with photothermal and Cu/Zn/Si multiple ions releasing property. This innovative approach creates a thermionic effect by the release of bioactive ions (Cu2 and Zn2 and SiO2- 3 ) from the composite hydrogel and the mild heat environment though the photothermal effect of the composite hydrogel induced by near-infrared light irradiation. The most distinctive advantage of this thermionic effect is to substantially eliminate periodontal pathogenic bacteria and inhibit inflammation, while simultaneously enhance peri-implant osseointegration. This unique attribute renders the use of this composite hydrogel highly effective in significantly improving the survival rate of implants after intervention in peri-implant lesions, which is a clinical challenge in periodontics. This study reveals application potential of a new biomaterial-based approach for peri-implant lesion, as it not only eliminates the infection and inflammation, but also enhances the osteointegration of the dental implant, which provides theoretical insights and practical guidance to prevent and manage early-stage peri-implant lesion using bioactive functional materials. © The Author(s) 2024.
资助项目	Natural Science Foundation of Sichuan Province of China[2022NSFSC1469];National Natural Science Foundation of China[81991500,81991503];Key Laboratory of Rehabilitation Medicine in Sichuan Province of China[KFYXSZDSYS-01];Science and Technology Commission of Shanghai Municipality[18ZR1422400];Shanghai JiaoTong University School of Medicine[JYJC201904];Innovative Research Team of High-level Local Universities in Shanghai[SSMU-ZDCX20180900];
出版者	Oxford University Press
ISSN	2056-3418
EISSN	2056-3426
卷号	11
DOI	10.1093/rb/rbae028
收录类别	EI ; SCOPUS
EI入藏号	20241615927297
EI主题词	Silica
EI分类号	461.6 Medicine and Pharmacology ; 801.3 Colloid Chemistry ; 804 Chemical Products Generally ; 951 Materials Science
URL	查看原文
SCOPUSEID	2-s2.0-85190261718
通讯作者地址	[Xie, Yufeng]Department of Periodontology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai,China ; [Chang, Jiang]Joint Centre of Translational Medicine,the First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Biomaterials
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212584
专题	第一临床医学院（信息与工程学院）、附属第一医院附属第一医院
通讯作者	Chang, Jiang; Xie, Yufeng
作者单位	1.Department of Periodontology,Shanghai Ninth People's Hospital,Shanghai Jiao Tong University,School of Medicine,Shanghai,China; 2.College of Stomatology,Shanghai Jiao Tong University,National Center for Stomatology,National Clinical Research Center for Oral Diseases,Shanghai Key Laboratory of Stomatology,Shanghai Research Institute of Stomatology,Shanghai,China; 3.Joint Centre of Translational Medicine,the First Affiliated Hospital,Wenzhou Medical University,Wenzhou,325000,China; 4.Zhejiang Engineering Research Center for Tissue Repair Materials,Wenzhou Institute,University of Chinese Academy of Sciences,Wenzhou,325000,China; 5.State Key Laboratory of High-Performance Ceramics and Superfine Microstructure,Shanghai Institute of Ceramics,Chinese Academy of Sciences,Shanghai,200050,China; 6.Key Laboratory of Rehabilitation Medicine in Sichuan Province,West China Hospital,Sichuan University,Chengdu,China; 7.Department of Periodontology,Shanghai Stomatological Hospital & School of Stomatology,Fudan University,Shanghai,China; 8.Shanghai Key Laboratory of Craniomaxillofacial Development and Diseases,Fudan University,Shanghai,China
通讯作者单位	第一临床医学院（信息与工程学院）、附属第一医院; 附属第一医院
推荐引用方式 GB/T 7714	Xia, Yiru,Zhang, Zhaowenbin,Zhou, Kecong,et al. Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion[J]. Regenerative Biomaterials,2024,11.
APA	Xia, Yiru., Zhang, Zhaowenbin., Zhou, Kecong., Lin, Zhikai., Shu, Rong., ... & Xie, Yufeng. (2024). Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion. Regenerative Biomaterials, 11.
MLA	Xia, Yiru,et al."Cuprorivaite/hardystonite/alginate composite hydrogel with thermionic effect for the treatment of peri-implant lesion".Regenerative Biomaterials 11(2024).