Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse

doi:10.1007/s10753-024-02032-3

科研成果详情

题名	Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse
作者	Cai, Lu-Qiong 1; Li, Xiu-Chun 1; Wang, Yang-Yue1; Chen, Yu-Xin 1; Zhu, Xia-Yan 1; Zuo, Zi-Yi1; Si-Ma, Yi-Qun 1; Lin, Yi-Nuo 1; Li, Xiao-Kun2; Huang, Xiao-Ying 1
发表日期	2024-04-24
发表期刊	INFLAMMATION 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	aging fibroblast growth factor 21 inflammatory response fatty liver transcriptomics metabolomics and lipidomics
其他关键词	LYSOPHOSPHATIDYLCHOLINE ; IDENTIFICATION ; ACID
摘要	Aging is a physiological condition accomplished with persistent low-grade inflammation and metabolic disorders. FGF21 has been reported to act as a potent longevity determinant, involving inflammatory response and energy metabolism. In this study, we engineered aging FGF21 knockout mice of 36-40 weeks and observed that FGF21 deficiency manifests a spontaneous inflammatory response of lung and abnormal accumulation of lipids in liver. On one hand, inflamed state in lungs and increased circulating inflammatory cytokines were found in FGF21 knockout mice of 36-40 weeks. To evaluate the ability of FGF21 to suppress inflammation, a subsequent study found that FGF21 knockout aggravated LPS-induced pulmonary exudation and inflammatory infiltration in mice, while exogenous administration of FGF21 reversed these malignant phenotypes by enhancing microvascular endothelial junction. On the other hand, FGF21 knockout induces fatty liver in aging mice, characterized by excessive accumulation of triglycerides within hepatocytes. Further quantitative metabolomics and lipidomics analysis revealed perturbed metabolic profile in liver lacking FGF21, including disrupted glucose and lipids metabolism, glycerophospholipid metabolism, and amino acid metabolism. Taken together, this investigation reveals the protective role of FGF21 during aging by weakening the inflammatory response and balancing energy metabolism.
资助项目	Key scientific research project of Wenzhou[2020ZY0036];Science and Technology Innovation Activity Plan for College Students of Zhejiang Province[2022R413A040];
出版者	SPRINGER/PLENUM PUBLISHERS
ISSN	0360-3997
EISSN	1573-2576
DOI	10.1007/s10753-024-02032-3
页数	23
WOS类目	Cell Biology ; Immunology
WOS研究方向	Cell Biology ; Immunology
WOS记录号	WOS:001207102100001
收录类别	SCIE ; SCOPUS ; PUBMED
在线发表日期	2024-04
URL	查看原文
PubMed ID	38653921
SCOPUSEID	2-s2.0-85191091960
通讯作者地址	[Huang, Xiao-Ying]Division of Pulmonary Medicine,the First Affiliated Hospital,Wenzhou Medical University,Wenzhou Key Laboratory of Interdiscipline and Translational Medicine,Wenzhou Key Laboratory of Heart and Lung,Zhejiang,Wenzhou,325000,China
Scopus学科分类	Immunology and Allergy;Immunology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212549
专题	附属第一医院药学院（分析测试中心）第一临床医学院（信息与工程学院）、附属第一医院_硕士
通讯作者	Huang, Xiao-Ying
作者单位	1.Division of Pulmonary Medicine,the First Affiliated Hospital,Wenzhou Medical University,Wenzhou Key Laboratory of Interdiscipline and Translational Medicine,Wenzhou Key Laboratory of Heart and Lung,Zhejiang,Wenzhou,325000,China; 2.School of Pharmacy,Wenzhou Medical University,Chashan University Park, Zhejiang,Wenzhou,325000,China
第一作者单位	附属第一医院
通讯作者单位	附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Cai, Lu-Qiong,Li, Xiu-Chun,Wang, Yang-Yue,et al. Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse[J]. INFLAMMATION,2024.
APA	Cai, Lu-Qiong., Li, Xiu-Chun., Wang, Yang-Yue., Chen, Yu-Xin., Zhu, Xia-Yan., ... & Huang, Xiao-Ying. (2024). Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse. INFLAMMATION.
MLA	Cai, Lu-Qiong,et al."Investigation of Metabolic and Inflammatory Disorder in the Aging FGF21 Knockout Mouse".INFLAMMATION (2024).