Determination of Ketamine and Palmatine in Rat Plasma by UHPLC-MS/MS and their Pharmacokinetic Interaction

doi:10.2174/0115734129304769240403075839

科研成果详情

题名	Determination of Ketamine and Palmatine in Rat Plasma by UHPLC-MS/MS and their Pharmacokinetic Interaction
作者	Huang, Xueli1; Ma, Yizhe 2; Wang, Ziyue 2; Wang, Wanhang 2; Wen, Congcong 2; Wang, Xianqin1; Zhang, Meiling1
发表日期	2024-04-15
发表期刊	CURRENT PHARMACEUTICAL ANALYSIS 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	Ketamine palmatine pharmacokinetic interaction UHPLC-MS/MS mean residence time (MRT)
摘要	Objective Ketamine, commonly known as K-powder, is increasingly being abused as a prom drug. Palmatine, a typical isoquinoline alkaloid, is mainly found in the roots and stems of natural Chinese herbal medicine plants such as Phellodendron chinense, Coptis chinensis, Sankezhen and Nantianzhu. Herein, we aim to establish a UHPLC-MS/MS method to determine ketamine and palmatine concentrations in rat plasma and investigate the pharmacokinetic interaction of ketamine and palmatine.Methods Three groups of eighteen rats each were assigned to ketamine, palmatine, ketamine and palmatine. The pharmacokinetic interaction between ketamine and palmatine was demonstrated using UHPLC-MS/MS.Results When ketamine was combined with palmatine, the mean residence time (MRT) was significantly different from that of the ketamine group. MRT decreased after combined use. The interaction showed that palmatine can influence the mean residence time of ketamine; no significant differences were observed for other pharmacokinetic parameters between the ketamine or palmatine group and the ketamine-palmatine group.Conclusion Palmatine may influence the mean residence time of ketamine.
资助项目	Wenzhou Science and Technology Bureau [Y2020069]
出版者	BENTHAM SCIENCE PUBL LTD
ISSN	1573-4129
EISSN	1875-676X
卷号	20 期号:3 页码:224-229
DOI	10.2174/0115734129304769240403075839
页数	6
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001208669600001
收录类别	SCIE ; SCOPUS
在线发表日期	2024-04
URL	查看原文
SCOPUSEID	2-s2.0-85196319617
通讯作者地址	[Wang, Xianqin;Zhang, Meiling]Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China.
Scopus学科分类	Biophysics;Biochemistry;Molecular Medicine;Pharmaceutical Science
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212533
专题	药学院（分析测试中心）实验动物中心
通讯作者	Wang, Xianqin; Zhang, Meiling
作者单位	1.Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou, Peoples R China; 2.Wenzhou Med Univ, Lab Anim Ctr, Wenzhou, Peoples R China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Huang, Xueli,Ma, Yizhe,Wang, Ziyue,et al. Determination of Ketamine and Palmatine in Rat Plasma by UHPLC-MS/MS and their Pharmacokinetic Interaction[J]. CURRENT PHARMACEUTICAL ANALYSIS,2024,20(3):224-229.
APA	Huang, Xueli., Ma, Yizhe., Wang, Ziyue., Wang, Wanhang., Wen, Congcong., ... & Zhang, Meiling. (2024). Determination of Ketamine and Palmatine in Rat Plasma by UHPLC-MS/MS and their Pharmacokinetic Interaction. CURRENT PHARMACEUTICAL ANALYSIS, 20(3), 224-229.
MLA	Huang, Xueli,et al."Determination of Ketamine and Palmatine in Rat Plasma by UHPLC-MS/MS and their Pharmacokinetic Interaction".CURRENT PHARMACEUTICAL ANALYSIS 20.3(2024):224-229.