Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma

doi:10.4251/wjgo.v16.i4.1514

科研成果详情

题名	Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma
作者	Pan, Yong1; Zhang, Yi-Ru1,2; Wang, Ling-Yun1,2; Wu, Li-Na3; Ma, Ying-Qiu1; Fang, Zhou1; Li, Shi-Bo1
发表日期	2024-04-15
发表期刊	WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Hepatocellular carcinoma Competitive endogenous RNA Molecular mechanism Prognosis Biomarker
其他关键词	COMPREHENSIVE ANALYSIS ; CANCER ; GENE
摘要	BACKGROUND Competitive endogenous RNA (ceRNA) is an innovative way of gene expression modulation, which plays a crucial part in neoplasia. However, the intricacy and behavioral characteristics of the ceRNA network in hepatocellular carcinoma (HCC) remain dismal. AIM To establish a cyclin dependent kinase inhibitor 2A (CDKN2A)-related ceRNA network and recognize potential prognostic indicators for HCC. METHODS The mutation landscape of CDKN2A in HCC was first explored using the cBioPortal database. Differential expression analysis was implemented between CDKN2A(high) and CDKN2A(low )expression HCC samples. The targeted microRNAs were predicted by lncBasev3.0, and the targeted mRNAs were predicted by miRDB, and Targetscan database. The univariate and multivariate analysis were utilized to identify independent prognostic indicators. RESULTS CDKN2A was frequently mutated and deleted in HCC. The single-cell RNA-sequencing analysis revealed that CDKN2A participated in cell cycle pathways. The CDKN2A-related ceRNA network-growth arrest specific 5 (GAS5)/miR-25-3p/SRY-box transcription factor 11 (SOX11) was successfully established. GAS5 was recognized as an independent prognostic biomarker, whose overexpression was correlated with a poor prognosis in HCC patients. The association between GAS5 expression and methylation, immune infiltration was explored. Besides, traditional Chinese medicine effective components targeting GAS5 were obtained. CONCLUSION This CDKN2A-related ceRNA network provides innovative insights into the molecular mechanism of HCC formation and progression. Moreover, GAS5 might be a significant prognostic biomarker and therapeutic target in HCC.
资助项目	Zhejiang Province Major Science and Technology Project for Medicine and Health [WKJ-ZJ-2329]
出版者	BAISHIDENG PUBLISHING GROUP INC
ISSN	1948-5204
卷号	16 期号:4 页码:1514-1531
DOI	10.4251/wjgo.v16.i4.1514
页数	19
WOS类目	Oncology ; Gastroenterology & Hepatology
WOS研究方向	Oncology ; Gastroenterology & Hepatology
WOS记录号	WOS:001208073600008
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38660664
SCOPUSEID	2-s2.0-85190691318
通讯作者地址	[Li, Shi-Bo]Department of Infectious Disease,Zhoushan Hospital,Wenzhou Medical University,No. 739 Dingshen Road, Zhejiang Province,Zhoushan,316021,China
Scopus学科分类	Oncology;Gastroenterology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212495
专题	其他_附属舟山医院（舟山医院）附属第一医院
通讯作者	Li, Shi-Bo
作者单位	1.Department of Infectious Disease,Zhoushan Hospital,Wenzhou Medical University,Zhejiang Province,Zhoushan,316021,China; 2.State Key Laboratory for the Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital of Zhejiang University,Zhejiang Province,Hangzhou,310003,China; 3.Department of Infectious Disease,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang Province,Wenzhou,325035,China
第一作者单位	其他_附属舟山医院（舟山医院）
通讯作者单位	其他_附属舟山医院（舟山医院）
第一作者的第一单位	其他_附属舟山医院（舟山医院）
推荐引用方式 GB/T 7714	Pan, Yong,Zhang, Yi-Ru,Wang, Ling-Yun,et al. Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma[J]. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY,2024,16(4):1514-1531.
APA	Pan, Yong., Zhang, Yi-Ru., Wang, Ling-Yun., Wu, Li-Na., Ma, Ying-Qiu., ... & Li, Shi-Bo. (2024). Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma. WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY, 16(4), 1514-1531.
MLA	Pan, Yong,et al."Construction of CDKN2A-related competitive endogenous RNA network and identification of GAS5 as a prognostic indicator for hepatocellular carcinoma".WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY 16.4(2024):1514-1531.