Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial

doi:10.1177/20420986241244593

科研成果详情

题名	Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial
作者	Chen, Nanjin 1; Ji, Shuman 2; Liu, Junfei3; Wang, Liping1; Chen, Fenglin 1; Zhu, Yanwu 4; Li, Jiao 1; Chen, Minjuan 1; Chen, Lingyang1; Wang, Mingcang 1; He, Ruyi 1; Mei, Xiaopeng 2; Zhang, Zhanqin 2; Jin, Shengwei5; Zheng, Jingming 6; Jiang, Yongpo6
发表日期	2024
发表期刊	Therapeutic Advances in Drug Safety 影响因子和分区
语种	英语
原始文献类型	Article
关键词	gynecologic laparoscopic surgery olanzapine postoperative nausea and vomiting
其他关键词	CHEMOTHERAPY-INDUCED NAUSEA ; RISK-FACTORS ; MANAGEMENT
摘要	Purpose: This study was designed to investigate the prophylactic effect of oral olanzapine in postoperative nausea and vomiting after gynecologic laparoscopic surgery.Methods: ASA I-II, aged 18-75 years, planned to undergo gynecologic laparoscopic surgery with general anesthesia in adult female patients. Using the randomized numbers table, the patients were placed in two groups. Oral olanzapine 5 mg or placebo was given 1 h before anesthesia. All patients received standard antiemetic prophylaxis with dexamethasone and granisetron. The primary outcome was nausea and/or vomiting in the 24 h after the postoperative.Results: A total of 250 patients were randomized, and 241 were analyzed. The primary outcome occurred in 10 of 120 patients (8.3%) in the olanzapine group and 23 of 121 patients (19.2%) in the placebo group (p = 0.014). According to Kaplan-Meier analysis, the probabilities of nausea and/or vomiting in the 24 h after the postoperative in the olanzapine group were lower than in the placebo group (log-rank p = 0.014). In a multivariate Cox analysis, the variables of use of olanzapine [hazard ratio (HR): 0.35, 95% confidence interval (CI): 0.16-0.79; p = 0.012] and use of vasoactive drugs (HR: 2.48, 95% CI: 1.07-5.75; p = 0.034) were independently associated with nausea and/or vomiting in the 24 h after the postoperative.Conclusion: Our data suggest that olanzapine relative to placebo decreased the risk of nausea and/or vomiting in the 24 h after gynecologic laparoscopic surgery.Trial registration: The trial was registered prior to patient enrollment at The Chinese Clinical Trial Registry (https://www.chictr.org.cn/showproj.html?proj=166900, link to registry page, Principal investigator: Nanjin Chen, Date of registration: 25 April 2022). Preventing nausea and vomiting after laparoscopic gynecological surgery: the benefits of using olanzapineWhy was this study done? Despite the use of antiemetics, postoperative nausea and vomiting remain prevalent. Furthermore, patients who undergo gynecological laparoscopic surgery are at an increased risk. Therefore, this study investigated whether oral Olanzapine could reduce the incidence of nausea and vomiting after gynaecological Laparoscopy?What did the researchers do? The research team examined patients who underwent gynecological laparoscopic surgery under general anesthesia. They observed the occurrence of nausea and vomiting within 24 hours after surgery in patients who either received or did not receive Olanzapine treatment. The goal was to assess the effectiveness of Olanzapine in reducing postoperative nausea and vomiting.What did the researchers find? The addition of Olanzapine, when combined with granisetron and dexamethasone, resulted in a decreased risk of nausea and/or vomiting within the 24 hours following gynecologic laparoscopic surgery, as compared to the placebo. Administering oral Olanzapine at a dosage of 5 mg reduced the incidence of nausea and vomiting after gynecological laparoscopy from 19.2% to 8.3%.What do the findings mean? This study has identified a safe and effective medication for preventing postoperative nausea and vomiting. Implementing Olanzapine as a preventive measure can significantly reduce the incidence of nausea and vomiting following surgery, thereby enhancing the overall medical experience for patients.
资助项目	The Science and Technology Project of Taizhou[21ywb05,23ywa47];The Medicines Health Research Fund of Zhejiang[2024ky1784,2022KY435];
出版者	SAGE PUBLICATIONS LTD
ISSN	2042-0986
EISSN	2042-0994
卷号	15
DOI	10.1177/20420986241244593
页数	10
WOS类目	Pharmacology & Pharmacy
WOS研究方向	Pharmacology & Pharmacy
WOS记录号	WOS:001205135600001
收录类别	SCIE ; SCOPUS ; PUBMED
URL	查看原文
PubMed ID	38646425
SCOPUSEID	2-s2.0-85190859140
通讯作者地址	[Jiang, Yongpo]Department of Critical Care Medicine,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,No. 150, Ximen Street,Taizhou,317000,China
Scopus学科分类	Pharmacology (medical)
SCOPUS_ID	SCOPUS_ID:85190859140
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/212478
专题	第二临床医学院、附属第二医院、育英儿童医院附属第二医院附属台州医院其他_附属台州医院（浙江省台州医院）
通讯作者	Jiang, Yongpo
作者单位	1.Department of Anesthesiology,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,Taizhou,China; 2.Department of Anesthesiology,The First Affiliated Hospital of Xi’an Jiaotong University,Xi’an,China; 3.Department of Pathology,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,China; 4.Department of Pharmacy,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,China; 5.Department of Anaesthesia and Critical Care,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,325088,China; 6.Department of Critical Care Medicine,Taizhou Hospital of Zhejiang Province Affiliated to Wenzhou Medical University,No. 150, Ximen Street,Taizhou,317000,China
第一作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
通讯作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
第一作者的第一单位	附属台州医院（浙江省台州医院）
推荐引用方式 GB/T 7714	Chen, Nanjin,Ji, Shuman,Liu, Junfei,et al. Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial[J]. Therapeutic Advances in Drug Safety,2024,15.
APA	Chen, Nanjin., Ji, Shuman., Liu, Junfei., Wang, Liping., Chen, Fenglin., ... & Jiang, Yongpo. (2024). Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial. Therapeutic Advances in Drug Safety, 15.
MLA	Chen, Nanjin,et al."Olanzapine for the prevention of postoperative nausea and vomiting after gynecologic laparoscopic surgery: a randomized controlled trial".Therapeutic Advances in Drug Safety 15(2024).