Enhancing mechanical strength, tribological properties, cytocompatibility, osteogenic differentiation, and antibacterial capacity of biodegradable Zn-5RE (RE = Nd, Y, and Ho) alloys for potential bone-implant application

doi:10.1016/j.jmrt.2024.04.015

科研成果详情

题名	Enhancing mechanical strength, tribological properties, cytocompatibility, osteogenic differentiation, and antibacterial capacity of biodegradable Zn-5RE (RE = Nd, Y, and Ho) alloys for potential bone-implant application
作者	Huang, Xiande 1; Miu, Daoyi 2; Zhou, Runqi 3; Shen, Xinkun2; Tong, Xian4,5; Lin, Jixing4; Wang, Shoudu 6
发表日期	2024-05-01
发表期刊	Journal of Materials Research and Technology 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Alloying elements Bearings (machine parts) Binary alloys Biodegradability Biomechanics Corrosion rate Corrosive effects Degradation Escherichia coli Hot rolling Magnesium alloys Rare earths Tensile strength Zinc alloys Bio-tribology behavior Biotribology Bone implant material Corrosion behaviour Hot-rolled Load-bearing Rare-earths Tribological properties Tribology behavior Zinc-rare earth binary alloy
其他关键词	RARE-EARTH-ELEMENTS ; THERMODYNAMIC PROPERTIES ; CORROSION BEHAVIOR ; MATRIX COMPOSITES ; MAGNESIUM ALLOYS ; PHASE-DIAGRAMS ; WEAR BEHAVIOR ; ZN SYSTEMS ; ZINC ; DY
摘要	Degradable zinc (Zn) based metals exhibit great promise as potential load-bearing bone-implant materials due to their suitable biodegradability, good fabricate-friendliness, biocompatibility, and favorable osteogenesis-promoting capacity. Nevertheless, most as-cast Zn-based metals display poor mechanical properties due to their coarse grain size and few slip systems, which is challenging to meet bone-implant application requirements. Herein, the alloying using rare earth (RE) elements of neodymium (Nd), yttrium (Y), and holmium (Ho) combined with hot-rolling was used to prepare the hot-rolled (HR) Zn-5RE binary alloys for load-bearing bone fixation or bone repair applications. HR Zn–5Y sample demonstrated the best mechanical properties matching with an ultimate tensile strength of ∼260 MPa, yield strength of ∼200 MPa, elongation of ∼43.5%, strength-elongation product of ∼11.3 GPa%, and macro-hardness of ∼104.7 HB among the HR samples, close to the requirements of mechanical properties for degradable bone-implant materials. HR Zn–5Y sample exhibited the lowest corrosion rate of ∼178 μm/y measured by electrochemical polarization testing, the degradation rate of ∼29 μm/y measured by static immersion testing, and high tribological properties in Hanks’ solution. The diluted Zn–5Y extract showed an appropriate cytocompatibility to 3T3 and MG-63 cells and moderate osteogenic differentiation ability to 3T3 cells among HR Zn-5RE and pure Zn extracts. Meanwhile, the HR Zn–5Y sample showed a suitable and effective antibacterial capacity against S. aureus and E. coli. Overall, the HR Zn–5Y sample is a promising moderate load-bearing bone-implant material for bone pins, plates, and guiding bone regeneration membrane application. © 2024 The Authors
资助项目	Zhejiang Public Welfare Technology Application Research Project of China[LTGY24H140002,LGF22H140008];
出版者	Elsevier Editora Ltda
ISSN	2238-7854
EISSN	2214-0697
卷号	30 页码:2865-2878
DOI	10.1016/j.jmrt.2024.04.015
页数	14
WOS类目	Materials Science, Multidisciplinary ; Metallurgy & Metallurgical Engineering
WOS研究方向	Materials Science ; Metallurgy & Metallurgical Engineering
WOS记录号	WOS:001228452100002
收录类别	EI ; SCOPUS ; SCIE
EI入藏号	20241515892114
EI主题词	Biocompatibility
EI分类号	461.3 Biomechanics, Bionics and Biomimetics ; 461.9.1 Immunology ; 531.1 Metallurgy ; 535.1.2 Rolling Mill Practice ; 539.1 Metals Corrosion ; 542.2 Magnesium and Alloys ; 546.3 Zinc and Alloys ; 549.2 Alkaline Earth Metals ; 601.2 Machine Components ; 801.2 Biochemistry ; 802.2 Chemical Reactions ; 804.2 Inorganic Compounds
URL	查看原文
SCOPUSEID	2-s2.0-85189744682
通讯作者地址	[Tong, Xian]Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Lin, Jixing]Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Wang, Shoudu]Department of Sports Science,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Ceramics and Composites;Biomaterials;Surfaces, Coatings and Films;Metals and Alloys
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211364
专题	其他_附属第三医院（瑞安市人民医院）温州医科大学口腔医学院、附属口腔医院_口腔医学研究所
通讯作者	Tong, Xian; Lin, Jixing; Wang, Shoudu
作者单位	1.Department of Sports,Zhejiang Wanli University,Ningbo,315100,China; 2.Department of Orthopaedics,The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital),Wenzhou,325016,China; 3.Chongqing Key Laboratory of Oral Disease and Biomedical Sciences and Chongqing Municipal Key Laboratory of Oral Biomedical Engineering,Higher Education and Stomatological Hospital,Chongqing Medical University,Chongqing,401174,China; 4.Institute of Stomatology,School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China; 5.School of Materials Science and Engineering,Xiangtan University,Xiangtan,411105,China; 6.Department of Sports Science,Wenzhou Medical University,Wenzhou,325027,China
通讯作者单位	口腔医学院、附属口腔医院_口腔医学研究所; 温州医科大学
推荐引用方式 GB/T 7714	Huang, Xiande,Miu, Daoyi,Zhou, Runqi,et al. Enhancing mechanical strength, tribological properties, cytocompatibility, osteogenic differentiation, and antibacterial capacity of biodegradable Zn-5RE (RE = Nd, Y, and Ho) alloys for potential bone-implant application[J]. Journal of Materials Research and Technology,2024,30:2865-2878.
APA	Huang, Xiande., Miu, Daoyi., Zhou, Runqi., Shen, Xinkun., Tong, Xian., ... & Wang, Shoudu. (2024). Enhancing mechanical strength, tribological properties, cytocompatibility, osteogenic differentiation, and antibacterial capacity of biodegradable Zn-5RE (RE = Nd, Y, and Ho) alloys for potential bone-implant application. Journal of Materials Research and Technology, 30, 2865-2878.
MLA	Huang, Xiande,et al."Enhancing mechanical strength, tribological properties, cytocompatibility, osteogenic differentiation, and antibacterial capacity of biodegradable Zn-5RE (RE = Nd, Y, and Ho) alloys for potential bone-implant application".Journal of Materials Research and Technology 30(2024):2865-2878.