Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modelling analysis

doi:10.1016/j.ijid.2024.107045

科研成果详情

题名	Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modelling analysis
作者	Yu, Jiafei 1,2; Zhang, Kai 1; Chen, Tianqi 3; Lin, Ronghai 4; Chen, Qijiang 5; Chen, Chensong 6; Tong, Minfeng 7; Chen, Jianping 8; Yu, Jianhua 9; Lou, Yuhang 1; Xu, Panpan 4; Zhong, Chao 1,5; Chen, Qianfeng 6; Sun, Kangwei 8; Liu, Liyuan 9; Cao, Lanxin 1; Zheng, Cheng 4; Wang, Ping 5; Chen, Qitao 7; Yang, Qianqian 7; Chen, Weiting 1,10; Wang, Xiaofang 11; Yan, Zuxi 2; Zhang, Xuefeng 12; Cui, Wei 1; Chen, Lin 7; Zhang, Zhongheng 3; Zhang, Gensheng 1,13
发表日期	2024-04-09
发表期刊	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	COVID-19 group-based multitrajectory modelling intensive care unit multiple-organ dysfunction sequential organ failure assessment score
摘要	The course of organ dysfunction (OD) in Corona Virus Disease 2019 (COVID-19) patients is unknown. Herein, we analyse the temporal patterns of OD in intensive care unit-admitted COVID-19 patients., Sequential organ failure assessment scores were evaluated daily within 2 weeks of admission to determine the temporal trajectory of OD using group-based multitrajectory modelling (GBMTM)., 392 patients were enrolled with a 28-day mortality rate of 53.6%. GBMTM identified four distinct trajectories. Group 1 (mild OD, n=64), with a median APACHE II score of 13 (IQR 9-21), had an early resolution of OD and a low mortality rate. Group 2 (moderate OD, n=140), with a median APACHE II score of 18 (IQR 13-22), had a 28-day mortality rate of 30.0%. Group 3 (severe OD, n=117), with a median APACHR II score of 20 (IQR 13-27), had a deterioration trend of respiratory dysfunction and a 28-day mortality rate of 69.2%. Group 4 (extremely severe OD, n=71), with a median APACHE II score of 20 (IQR 17-27), had a significant and sustained OD affecting all organ systems and a 28-day mortality rate of 97.2%., Four distinct trajectories of OD were identified, and respiratory dysfunction trajectory could predict nonpulmonary OD trajectories and patient prognosis.
资助项目	National Natural Science Foundations of China[81971871,82270086,82100012];Key Project of Jinhua City[2022-3-102];
出版者	ELSEVIER SCI LTD
ISSN	1201-9712
EISSN	1878-3511
卷号	144
DOI	10.1016/j.ijid.2024.107045
页数	10
WOS类目	Infectious Diseases
WOS研究方向	Infectious Diseases
WOS记录号	WOS:001239122500001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38604470
SCOPUSEID	2-s2.0-85192084816
通讯作者地址	[Zhang, Gensheng]Department of Critical Care Medicine,Second Affiliated Hospital,Zhejiang University School of Medicine,Key Laboratory of Multiple Organ Failure (Zhejiang University),Ministry of Education,Hangzhou,310009,China
Scopus学科分类	Microbiology (medical);Infectious Diseases
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211115
专题	第一临床医学院（信息与工程学院）、附属第一医院_急诊医学
通讯作者	Zhang, Gensheng
作者单位	1.Department of Critical Care Medicine,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310009,China; 2.Department of Critical Care Medicine,Haiyan People's Hospital,Zhejiang,314300,China; 3.Department of Emergency Medicine,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou,310016,China; 4.Department of Critical Care Medicine,Taizhou Municipal Hospital,Zhejiang,318000,China; 5.Intensive Care Unit,Ninghai First Hospital,Zhejiang,315600,China; 6.Intensive Care Unit,Xiangshan First People's Hospital Medical and Health Group,Zhejiang,315700,China; 7.Department of Neurosurgery,Affiliated Jinhua Hospital,Zhejiang University School of Medicine,Zhejiang,321000,China; 8.Department of Emergency Medicine,Dongyang People' Hospital of Wenzhou Medical University,Zhejiang,322100,China; 9.Department of Critical Care Medicine,Longquan People's Hospital,Zhejiang,323700,China; 10.Department of Emergency and Intensive Care Unit,The First People's Hospital of Linhai,Zhejiang,Taizhou,317000,China; 11.Department of Cardiovascular Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,310009,China; 12.Department of Critical Care Medicine,Second Affiliated Hospital,Jiaxing College School of Medicine,Jiaxing,314031,China; 13.Key Laboratory of Multiple Organ Failure (Zhejiang University),Ministry of Education,Hangzhou,310009,China
推荐引用方式 GB/T 7714	Yu, Jiafei,Zhang, Kai,Chen, Tianqi,et al. Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modelling analysis[J]. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases,2024,144.
APA	Yu, Jiafei., Zhang, Kai., Chen, Tianqi., Lin, Ronghai., Chen, Qijiang., ... & Zhang, Gensheng. (2024). Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modelling analysis. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 144.
MLA	Yu, Jiafei,et al."Temporal patterns of organ dysfunction in COVID-19 patients hospitalized in the intensive care unit: A group-based multitrajectory modelling analysis".International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 144(2024).