FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis

doi:10.1016/j.jare.2024.04.004

科研成果详情

题名	FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis
作者	Zhu, Junjie 1,2; Jin, Zhouxiang3; Wang, Jie 1; Wu, Zhaohang 1,2; Xu, Tianpeng1,2; Tong, Gaozan 2; Shen, Enzhao2; Fan, Junfu 1,2; Jiang, Chunhui 1,2; Wang, Jiaqi 1,2; Li, Xiaokun1,2,3; Cong, Weitao1,2,4; Lin, Li 1,2
发表日期	2024-04-09
发表期刊	Journal of advanced research 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Autophagy FGF21 HIF-1α Liver injury Macrophage Sepsis
摘要	Sepsis, a systemic immune syndrome caused by severe trauma or infection, poses a substantial threat to the health of patients worldwide. The progression of sepsis is heavily influenced by septic liver injury, which is triggered by infection and cytokine storms, and has a significant impact on the tolerance and prognosis of septic patients. The objective of our study is to elucidate the biological role and molecular mechanism of fibroblast growth factor 21 (FGF21) in the process of sepsis., This study was undertaken in an attempt to elucidate the function and molecular mechanism of FGF21 in therapy of sepsis., {AbstractText=Serum concentrations of FGF21 were measured in sepsis patients and septic mice. Liver injury was compared between mice FGF21 knockout (KO) mice and wildtype (WT) mice. To assess the therapeutic potential, recombinant human FGF21 was administered to septic mice. Furthermore, the molecular mechanism of FGF21 was investigated in mice with myeloid-cell specific HIF-1α overexpression mice (LyzM-CreDIO-HIF-1α) and myeloid-cell specific Atg7 knockout mice (Atg7△mye).}, {AbstractText=Serum level of FGF21 was significantly increased in sepsis patients and septic mice. Through the use of recombinant human FGF21 (rhFGF21) and FGF21 KO mice, we found that FGF21 mitigated septic liver injury by inhibiting the initiation and propagation of inflammation. Treatment with rhFGF21 effectively suppressed the activation of proinflammatory macrophages by promoting macroautophagy/autophagy degradation of hypoxia-inducible factor-1α (HIF-1α). Importantly, the therapeutic effect of rhFGF21 against septic liver injury was nullified in LyzM-CreDIO-HIF-1α mice and Atg7△mye mice.}, Our findings demonstrate that FGF21 considerably suppresses inflammation upon septic liver injury through the autophagy/ HIF-1α axis.
资助项目	Basic Public Welfare Research Foundation of Zhejiang Province[LZ23H310001];Haihe Laboratory of Cell Ecosystem Innovation Fund[HH22KYZX0007,22HHXBSS00006];National Natural Science Foundation of China[82172117,82372149,82070507];
出版者	Elsevier B.V.
ISSN	2090-1224
DOI	10.1016/j.jare.2024.04.004
收录类别	PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38599281
SCOPUSEID	2-s2.0-85190265542
通讯作者地址	[Lin, Li]School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Multidisciplinary
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211109
专题	药学院（分析测试中心）第二临床医学院，附属第二医院、育英儿童医院
通讯作者	Lin, Li
作者单位	1.Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine,Vision and Brain Health),School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,China; 2.School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,325000,China; 3.Department of Hepatobiliary Surgery,The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University,Wenzhou,China; 4.Haihe Laboratory of Cell Ecosystem,School of Pharmaceutical Science,Wenzhou Medical University,Wenzhou,China
第一作者单位	药学院（分析测试中心）
通讯作者单位	药学院（分析测试中心）
第一作者的第一单位	药学院（分析测试中心）
推荐引用方式 GB/T 7714	Zhu, Junjie,Jin, Zhouxiang,Wang, Jie,et al. FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis[J]. Journal of advanced research,2024.
APA	Zhu, Junjie., Jin, Zhouxiang., Wang, Jie., Wu, Zhaohang., Xu, Tianpeng., ... & Lin, Li. (2024). FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis. Journal of advanced research.
MLA	Zhu, Junjie,et al."FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis".Journal of advanced research (2024).