Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice

doi:10.1016/j.bbrc.2024.149809

科研成果详情

题名	Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice
作者	Bian, Jiaxin 1,2,8; Chen, Hongyu 2; Sun, Junhui3; Han, Shuai 4; Qi, Ming 1,2,5,6,7,8; Pan, Qing 1
发表日期	2024-05-21
发表期刊	Biochemical and biophysical research communications 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Hyperuricemia Rdh12 Uric acid
其他关键词	GENE ; GOUT ; VARIANT ; URATE ; DISRUPTION ; REDUCTION ; DYSTROPHY
摘要	Hyperuricemia is a chronic metabolic disease caused by purine metabolism disorder. And several gene loci and transporter proteins that associated with uric acid transport functions have been identified. Retinol Dehydrogenase 12 (RDH12), recognized for its role in safeguarding photoreceptors, and our study investigated the potential impact of Rdh12 mutations on other organs and diseases, particularly hyperuricemia. We assessed Rdh12 mRNA expression levels in various tissues and conducted serum biochemical analyses in Rdh12-/- mice. Compared with the wild type, significant alterations in serum uric acid levels and kidney-related biochemical indicators have been revealed. Then further analysis, including quantitative RT-PCR of gene expression in the liver and kidney, highlighted variations in the expression levels of specific genes linked to hyperuricemia. And renal histology assessment exposed mild pathological lesions in the kidneys of Rdh12-/- mice. In summary, our study suggests that Rdh12 mutations impact not only retinal function but also contribute to hyperuricemia and renal disease phenotypes in mice. Our finding implies that individuals with Rdh12 mutations may be prone to hyperuricemia and gout, emphasizing the significance of preventive measures and regular examinations in daily life
出版者	ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN	0006-291X
EISSN	1090-2104
卷号	709
DOI	10.1016/j.bbrc.2024.149809
页数	6
WOS类目	Biochemistry & Molecular Biology ; Biophysics
WOS研究方向	Biochemistry & Molecular Biology ; Biophysics
WOS记录号	WOS:001224367400001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38552555
SCOPUSEID	2-s2.0-85188929251
通讯作者地址	[Pan, Qing]Department of Ophthalmology,Zhejiang University Medical School 1st Affiliated Hospital,79 Qingchun Road,Hangzhou,China ; [Qi, Ming]Department of Cell Biology and Medical Genetics,School of Medicine Zhejiang University,Research Building A713, Yuhangtang Road 866,Hangzhou,China
Scopus学科分类	Biophysics;Biochemistry;Molecular Biology;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211056
专题	附属第一医院_生殖医学中心
通讯作者	Qi, Ming; Pan, Qing
作者单位	1.Department of Ophthalmology,Zhejiang University Medical School First Affiliated Hospital,Hangzhou,310000,China; 2.Department of Cell Biology and Medical Genetics,School of Medicine Zhejiang University,Hangzhou,310000,China; 3.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China; 4.Center for Reproductive Medicine,Department of Reproductive Endocrinology,Zhejiang Provincial People's Hospital(Affiliated People's Hospital,Hangzhou Medical College),Zhejiang,Hangzhou,310000,China; 5.Assisted Reproduction Unit,Department of Obstetrics and Gynecology,Department of Laboratory Medicine,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Key Laboratory of Reproductive Dysfunction Management of Zhejiang Province,Hangzhou,310000,China; 6.DIAN Diagnostics,Hangzhou,310000,China; 7.Department of Pathology and Laboratory of Medicine,University of Rochester Medical Centre,NY,Rochester,14609,United States; 8.HVP-China,Hangzhou,310000,China
推荐引用方式 GB/T 7714	Bian, Jiaxin,Chen, Hongyu,Sun, Junhui,et al. Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice[J]. Biochemical and biophysical research communications,2024,709.
APA	Bian, Jiaxin, Chen, Hongyu, Sun, Junhui, Han, Shuai, Qi, Ming, & Pan, Qing. (2024). Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice. Biochemical and biophysical research communications, 709.
MLA	Bian, Jiaxin,et al."Retinol dehydrogenase 12 (RDH12) knock out may cause hyperuricemia phenotype in mice".Biochemical and biophysical research communications 709(2024).