Reproductive outcomes in patients with high levels of sperm DNA fragmentation using testicular sperm for intracytoplasmic injection: a retrospective analysis

doi:10.1080/14647273.2024.2338290

科研成果详情

题名	Reproductive outcomes in patients with high levels of sperm DNA fragmentation using testicular sperm for intracytoplasmic injection: a retrospective analysis
作者	Zhou, Haisu1; Pan, Chengshuang1,2; Wu, Yonggen1; Ye, Danna1,2; Fei, Qianjin1; Kong, Xiangbin1; Zhang, Huan1,2; Jin, Wumin 1,2
发表期刊	HUMAN FERTILITY 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Sperm DNA fragmentation male infertility assisted reproductive techniques testicular sperm blastocyst formation rate
其他关键词	CHROMATIN DISPERSION-TEST ; DAMAGE ; SPERMATOZOA ; MEN ; INSEMINATION ; RATES ; ICSI
摘要	This study aims to compare the embryological and clinical parameters of intracytoplasmic sperm injection (ICSI) cycles using testicular versus ejaculated sperm in male patients with elevated sperm DNA fragmentation (SDF). A total of 73 ICSI cycles were examined in couples where the male partner exhibited high levels of SDF. ICSI was performed using either ejaculated or testicular sperm. The primary outcomes were rates of blastocyst formation, high-quality embryo development, and clinical pregnancy. The DNA fragmentation index (DFI) for testicular sperm (16.81 +/- 17.51) was significantly lower than that of ejaculated sperm (56.96 +/- 17.56). While the blastocyst formation rate was significantly higher in the testicular sperm group compared to the ejaculated sperm group, no statistically significant differences were noted in fertilization rate (72.15% vs. 77.23%), rate of high-quality embryo formation (47.17% vs. 46.53%), clinical pregnancy (50% vs. 56.52%), Cumulative pregnancy (70.2% vs. 55.6%), or live birth rate (43.75% vs.43.48%). Testicular spermatozoa have no additional advantage over ejaculated spermatozoa except for blastocyst quality in patients with high SDF, the use of testicular spermatozoa for the first ICSI cycle in male infertility patients with high SDF should be undertaken after much consideration at present.
资助项目	Science and Technology Plan Project of Wenzhou, China
出版者	TAYLOR & FRANCIS LTD
ISSN	1464-7273
EISSN	1742-8149
卷号	27 期号:1
DOI	10.1080/14647273.2024.2338290
页数	7
WOS类目	Obstetrics & Gynecology ; Reproductive Biology
WOS研究方向	Obstetrics & Gynecology ; Reproductive Biology
WOS记录号	WOS:001200561900001
收录类别	SCIE ; PUBMED
发表日期	2024-12-31
URL	查看原文
Pubmed记录号	38602121
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/211007
专题	附属第一医院
通讯作者	Jin, Wumin
作者单位	1.Wenzhou Med Univ, Affiliated Hosp 1, Reprod Med Ctr, Wenzhou, Zhejiang, Peoples R China; 2.Wenzhou Key Lab Reprod & Genet, Wenzhou, Zhejiang, Peoples R China
第一作者单位	附属第一医院; 生殖医学中心
通讯作者单位	附属第一医院; 生殖医学中心
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Zhou, Haisu,Pan, Chengshuang,Wu, Yonggen,et al. Reproductive outcomes in patients with high levels of sperm DNA fragmentation using testicular sperm for intracytoplasmic injection: a retrospective analysis[J]. HUMAN FERTILITY,2024,27(1).
APA	Zhou, Haisu., Pan, Chengshuang., Wu, Yonggen., Ye, Danna., Fei, Qianjin., ... & Jin, Wumin. (2024). Reproductive outcomes in patients with high levels of sperm DNA fragmentation using testicular sperm for intracytoplasmic injection: a retrospective analysis. HUMAN FERTILITY, 27(1).
MLA	Zhou, Haisu,et al."Reproductive outcomes in patients with high levels of sperm DNA fragmentation using testicular sperm for intracytoplasmic injection: a retrospective analysis".HUMAN FERTILITY 27.1(2024).