Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection

doi:10.1186/s12885-024-12208-7

科研成果详情

题名	Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection
作者	Xiao, Yunzhou 1; Wen, Xiaoting 2; Ying, Yingying 1; Zhang, Xiaoyan 1; Li, Luyao1; Wang, Zhongchu 1; Su, Miaoguang 1; Miao, Shouliang 3
发表日期	2024-04-06
发表期刊	BMC Cancer 影响因子和分区
语种	英语
原始文献类型	Article
关键词	Spleen density Nomogram Prognosis Colorectal cancer Overall survival Disease-free survival
其他关键词	SURVIVAL ; COMPLICATIONS
摘要	Objective The objective of this study was to investigate the correlation between spleen density and the prognostic outcomes of patients who underwent curative resection for colorectal cancer (CRC). Methods The clinical data of patients who were diagnosed with CRC and underwent radical resection were retrospectively analyzed. Spleen density was determined using computed tomography. Analysis of spleen density in relation to overall survival (OS) and disease-free survival (DFS) utilizing the Kaplan-Meier method. Univariate and multivariate Cox regression models were used to screen for independent prognostic factors, and a nomogram was constructed to predict OS and DFS. Moreover, internally validated using a bootstrap resamplling method. Results Two hundred twelve patients were included, of whom 23 (10.85%) were defined as having a diffuse reduction of spleen density (DROSD) based on diagnostic cutoff values (spleen density <= 37.00HU). Kaplan-Meier analysis indicated that patients with DROSD had worse OS and DFS than those non-DROSD (P < 0.05). Multivariate Cox regression analysis revealed that DROSD, carbohydrate antigen 199 (CA199) > 37 U/mL, tumor node metastasis (TNM) stage III-IV, laparoscopy-assisted operation and American Society of Anesthesiology (ASA) score were independent risk factors for 3-year DFS. DROSD, CA199 > 37 U/mL, TNM stage III-IV, hypoalbuminemia, laparoscopy-assisted operation and ASA score were chosen as predictors of for 3-year OS. Nomograms showed satisfactory accuracy in predicting OS and DFS using calibration curves, decision curve analysis and bootstrap resamplling method. Conclusion Patients with DROSD who underwent curative resection have worse 3-year DFS and OS. The nomogram demonstrated good performance, particularly in predicting 3-year DFS with a net clinical benefit superior to well-established risk calculator.
出版者	BMC
ISSN	1471-2407
EISSN	1471-2407
卷号	24 期号:1
DOI	10.1186/s12885-024-12208-7
页数	14
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001198017500001
收录类别	SCIE ; PUBMED ; SCOPUS
URL	查看原文
PubMed ID	38582845
SCOPUSEID	2-s2.0-85189624681
通讯作者地址	[Su, Miaoguang]Department of Radiology,PingYang People’s Hospital,Wenzhou Medical University,Wenzhou,325400,China ; [Miao, Shouliang]Department of Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
Scopus学科分类	Oncology;Genetics;Cancer Research
SCOPUS_ID	SCOPUS_ID:85189624681
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210995
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_妇产科学
通讯作者	Su, Miaoguang; Miao, Shouliang
作者单位	1.Department of Radiology,PingYang People’s Hospital,Wenzhou Medical University,Wenzhou,325400,China; 2.Department of Obstetrics,PingYang People’s Hospital,Wenzhou Medical University,Wenzhou,325400,China; 3.Department of Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,325000,China
第一作者单位	温州医科大学
通讯作者单位	温州医科大学; 附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	温州医科大学
推荐引用方式 GB/T 7714	Xiao, Yunzhou,Wen, Xiaoting,Ying, Yingying,et al. Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection[J]. BMC Cancer,2024,24(1).
APA	Xiao, Yunzhou., Wen, Xiaoting., Ying, Yingying., Zhang, Xiaoyan., Li, Luyao., ... & Miao, Shouliang. (2024). Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection. BMC Cancer, 24(1).
MLA	Xiao, Yunzhou,et al."Correlation between spleen density and prognostic outcomes in patients with colorectal cancer after curative resection".BMC Cancer 24.1(2024).