Impact of different growth hormone levels on gut microbiota and metabolism in short stature

doi:10.1038/s41390-024-03140-4

科研成果详情

题名	Impact of different growth hormone levels on gut microbiota and metabolism in short stature
作者	Li, Lan1,2,3; Wang, Yu 1; Huang, Yinyin1; Lu, Yi1,4; Wang, Weiyi1; Chen, Xian1; Shan, Xiaoou5; Gao, Hongchang2,6; Yan, Zhihan1,4
发表日期	2024-04-06
发表期刊	PEDIATRIC RESEARCH 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
其他关键词	DEFICIENCY ; CHILDREN
摘要	BackgroundGrowth hormone deficiency(GHD) and idiopathic short stature(ISS) are the primary causes of short stature in children. Animal experiments have revealed a link between growth hormone(GH), gut microbiota and metabolism, however, limited information is available from human trials.MethodsFecal samples collected from GHD (n = 36), ISS (n = 32) and healthy control (HC) children(n = 16) were subjected to microbiome (16 S rRNA gene sequencing) and metabolome (nuclear magnetic resonance,NMR) analyses.ResultsGHD, ISS and HC exhibit distinct differences in beta diversity of gut microbiota.In addition, short stature (GHD and ISS) exhibit higher relative abundance of Prevotellaceae_NK3B31_group at genus level compared to HC, whereas Rodentibacter, Rothia, and Pelomonas showed lower abundance. Additionally,Fusobacterium_mortiferum was identified as the characteristic species of GHD. Moreover, glucose metabolism, pyruvate metabolism and pyrimidine metabolism might play significant roles for distinguishing between GHD and normal GH groups (ISS and HC). Furthermore, a disease prediction model based on differential bacteria and metabolites between GHD and ISS exhibited high diagnostic value.ConclusionThese findings highlight the characteristics of different GH levels on the gut microbiota and metabolism in children, providing novel perspectives for early diagnosis and prognostic treatment of short stature with abnormal GH levels.ImpactThe key message of our study is to identify human-relevant gut microbiota and host metabolic patterns that are interfered with growth hormone levels, and to develop biomarker models to identify short stature associated with growth hormone deficiency.We used idiopathic short stature as a control group for growth hormone deficiency, complementing the absence of height as a factor in the existing literature.Our study ultimately hopes to shed new light on the diagnosis and treatment of short stature children associated with growth hormone deficiency.
资助项目	National Natural Science Foundation of China [82100952, 82071902]; Wenzhou Science and Technology Bureau in China [Y20220269]
出版者	SPRINGERNATURE
ISSN	0031-3998
EISSN	1530-0447
卷号	96 期号:1 页码:115-123
DOI	10.1038/s41390-024-03140-4
页数	9
WOS类目	Pediatrics
WOS研究方向	Pediatrics
WOS记录号	WOS:001197698300001
收录类别	SCIE ; PUBMED ; SCOPUS
在线发表日期	2024-04
URL	查看原文
PubMed ID	38582946
SCOPUSEID	2-s2.0-85189608703
通讯作者地址	[Yan, Zhihan]Department of Radiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China ; [Gao, Hongchang]Institute of Metabonomics & amp;Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China ; [Shan, Xiaoou]Department of Pediatric Endocrinology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Pediatrics, Perinatology and Child Health
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210927
专题	第二临床医学院、附属第二医院、育英儿童医院药学院（分析测试中心）附属第二医院_核磁共振室
通讯作者	Shan, Xiaoou; Gao, Hongchang; Yan, Zhihan
作者单位	1.Department of Radiology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 2.Institute of Metabonomics & amp; Medical NMR,School of Pharmaceutical Sciences,Wenzhou Medical University,Wenzhou,China; 3.Department of Radiology,First affiliated Hospital of Huzhou University,Huzhou,China; 4.Wenzhou Key Laboratory of Structural and Functional Imaging,Wenzhou,China; 5.Department of Pediatric Endocrinology,The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University,Wenzhou,China; 6.Key Laboratory of Efficacy Evaluation of Traditional Chinese Medicine and encephalopathy research of Zhejiang Province,Wenzhou,China
第一作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 药学院（分析测试中心）
通讯作者单位	第二临床医学院，附属第二医院、育英儿童医院; 附属第二医院; 药学院（分析测试中心）
第一作者的第一单位	第二临床医学院，附属第二医院、育英儿童医院
推荐引用方式 GB/T 7714	Li, Lan,Wang, Yu,Huang, Yinyin,et al. Impact of different growth hormone levels on gut microbiota and metabolism in short stature[J]. PEDIATRIC RESEARCH,2024,96(1):115-123.
APA	Li, Lan., Wang, Yu., Huang, Yinyin., Lu, Yi., Wang, Weiyi., ... & Yan, Zhihan. (2024). Impact of different growth hormone levels on gut microbiota and metabolism in short stature. PEDIATRIC RESEARCH, 96(1), 115-123.
MLA	Li, Lan,et al."Impact of different growth hormone levels on gut microbiota and metabolism in short stature".PEDIATRIC RESEARCH 96.1(2024):115-123.