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TitleChronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions
Creator
Date Issued2025-03-29
Source PublicationAGING AND DISEASE   Impact Factor & Quartile
language英语
Original Document TypeArticle ; Early Access
Keywordcircadian rhythm tumor microenvironment tumor-infiltrating cells chronotherapy.
WOS KeywordT-CELLS ; IDENTIFICATION ; GENES
Abstract

Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous endeavor. Consequently, to enhance the use of time -based pharmaceutical therapies in oncology, combining existing knowledge on circadian rhythms' roles within the TME is essential. This perspective elucidates the functions of circadian rhythms in the TME across various stages of cancer development, progression, and metastasis. Specifically, aging, angiogenesis, and inflammation are implicated in modulating circadian rhythm within the TME. Furthermore, circadian rhythm exerts a profound influence on current cancer treatments and thereby generates chronotheray to manage tumors. From a TME perspective, circadian rhythm offers promising opportunities for cancer prevention and treatment; nevertheless, further study is needed to address unanswered scientific problems.;Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous endeavor. Consequently, to enhance the use of time -based pharmaceutical therapies in oncology, combining existing knowledge on circadian rhythms' roles within the TME is essential. This perspective elucidates the functions of circadian rhythms in the TME across various stages of cancer development, progression, and metastasis. Specifically, aging, angiogenesis, and inflammation are implicated in modulating circadian rhythm within the TME. Furthermore, circadian rhythm exerts a profound influence on current cancer treatments and thereby generates chronotheray to manage tumors. From a TME perspective, circadian rhythm offers promising opportunities for cancer prevention and treatment; nevertheless, further study is needed to address unanswered scientific problems.

Funding ProjectChinese Scholarship Council [202206240086] ; Program for Talents of Chongqing University Three Gorges Hospital [ZX-50010101-2022-347] ; Regional innovation cooperation project of Sichuan Province [23QYCX0136] ; Zhejiang Province Public Welfare Technology Application Research Project in China [TGY23H160090, LGF21H160029] ; Taizhou Science and Technology Project, Zhejiang Province [20ywb12] ; Traditional Chinese medicine of Zhejiang province science and technology plan project [2020ZB293] ; Chinese Scholarship Council [202206240086] ; Program for Talents of Chongqing University Three Gorges Hospital [ZX-50010101-2022-347] ; Regional innovation cooperation project of Sichuan Province [23QYCX0136] ; Zhejiang Province Public Welfare Technology Application Research Project in China [TGY23H160090, LGF21H160029] ; Taizhou Science and Technology Project, Zhejiang Province [20ywb12] ; Traditional Chinese medicine of Zhejiang province science and technology plan project [2020ZB293]
PublisherINT SOC AGING & DISEASE
ISSN2152-5250
DOI10.14336/AD.2024.0327
Page Number13
WOS SubjectGeriatrics & Gerontology
WOS Research AreaGeriatrics & Gerontology
WOS IDWOS:001194363200001
Indexed BySCIE
Online2025-03
PubmedId38607733
Corresponding author address[Wei, Wuran;Feng, Dechao]Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China. ; [Wei, Wuran;Feng, Dechao]Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China. ; [Ke, Mang;Yang, Yubo]Wenzhou Med Univ, Dept Urol, Taizhou Hosp Zhejiang Prov, Taizhou, Peoples R China. ; [Ke, Mang;Yang, Yubo]Wenzhou Med Univ, Dept Urol, Taizhou Hosp Zhejiang Prov, Taizhou, Peoples R China.
Citation statistics
Document TypeJournal article
Identifierhttps://kms.wmu.edu.cn/handle/3ETUA0LF/210880
Collection
Corresponding AuthorKe, Mang; Yang, Yubo; Wei, Wuran; Feng, Dechao
Affiliation
1.Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China;
2.Ningbo Clin Pathol Diag Ctr, Dept Pathol, Ningbo, Zhejiang, Peoples R China;
3.Anhui Med Univ, Dept Urol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China;
4.Southwest Med Univ, Dept Rehabil, Affiliated Hosp, Luzhou, Peoples R China;
5.Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov Affiliated, Dept Publ Res Platform, Linhai, Peoples R China;
6.Cedars Sinai Med Ctr, Los Angeles, CA USA;
7.Kyung Hee Univ, Dept Urol, Seoul, South Korea;
8.Wenzhou Med Univ, Dept Urol, Taizhou Hosp Zhejiang Prov, Taizhou, Peoples R China;
9.Chongqing Univ, Three Gorges Hosp, Dept Urol, Wanzhou, Chongqing, Peoples R China;
10.UCL, Div Surg & Intervent Sci, London W1W 7TS, England
Corresponding Author Affilication附属台州医院(浙江省台州医院);  附属台州医院
Recommended Citation
GB/T 7714
Li, Dengxiong,Yu, Qingxin,Wu, Ruicheng,et al. Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions[J]. AGING AND DISEASE,2025.
APA Li, Dengxiong., Yu, Qingxin., Wu, Ruicheng., Tuo, Zhouting., Zhu, Weizhen., ... & Feng, Dechao. (2025). Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions. AGING AND DISEASE.
MLA Li, Dengxiong,et al."Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions".AGING AND DISEASE (2025).

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