Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions

doi:10.14336/AD.2024.0327

科研成果详情

题名	Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions
作者	Li, Dengxiong ; Yu, Qingxin 2; Wu, Ruicheng 1; Tuo, Zhouting 3; Zhu, Weizhen 1; Wang, Jie 1; Shao, Fanglin 4; Ye, Luxia 5; Ye, Xing 6; Yoo, Koo Han 7; Ke, Mang8; Yang, Yubo 8,9; Wei, Wuran 1; Feng, Dechao 1,10
发表期刊	AGING AND DISEASE 影响因子和分区
语种	英语
原始文献类型	Article ; Early Access
关键词	circadian rhythm tumor microenvironment tumor-infiltrating cells chronotherapy.
其他关键词	T-CELLS ; IDENTIFICATION ; GENES
摘要	Numerous research works have emphasized the critical role that circadian rhythm plays in the tumor microenvironment (TME). The goal of clarifying chrono-pharmacological strategies for improving cancer treatment in clinical settings is a continuous endeavor. Consequently, to enhance the use of time -based pharmaceutical therapies in oncology, combining existing knowledge on circadian rhythms' roles within the TME is essential. This perspective elucidates the functions of circadian rhythms in the TME across various stages of cancer development, progression, and metastasis. Specifically, aging, angiogenesis, and inflammation are implicated in modulating circadian rhythm within the TME. Furthermore, circadian rhythm exerts a profound influence on current cancer treatments and thereby generates chronotheray to manage tumors. From a TME perspective, circadian rhythm offers promising opportunities for cancer prevention and treatment; nevertheless, further study is needed to address unanswered scientific problems.
资助项目	Chinese Scholarship Council [202206240086]; Program for Talents of Chongqing University Three Gorges Hospital [ZX-50010101-2022-347]; Regional innovation cooperation project of Sichuan Province [23QYCX0136]; Zhejiang Province Public Welfare Technology Application Research Project in China [TGY23H160090, LGF21H160029]; Taizhou Science and Technology Project, Zhejiang Province [20ywb12]; Traditional Chinese medicine of Zhejiang province science and technology plan project [2020ZB293]
出版者	INT SOC AGING & DISEASE
ISSN	2152-5250
DOI	10.14336/AD.2024.0327
页数	13
WOS类目	Geriatrics & Gerontology
WOS研究方向	Geriatrics & Gerontology
WOS记录号	WOS:001194363200001
收录类别	SCIE
发表日期	2025-03-29
Pubmed记录号	38607733
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210880
专题	其他_附属台州医院（浙江省台州医院）
通讯作者	Ke, Mang; Yang, Yubo; Wei, Wuran; Feng, Dechao
作者单位	1.Sichuan Univ, West China Hosp, Inst Urol, Dept Urol, Chengdu, Peoples R China; 2.Ningbo Clin Pathol Diag Ctr, Dept Pathol, Ningbo, Zhejiang, Peoples R China; 3.Anhui Med Univ, Dept Urol, Affiliated Hosp 2, Hefei, Anhui, Peoples R China; 4.Southwest Med Univ, Dept Rehabil, Affiliated Hosp, Luzhou, Peoples R China; 5.Wenzhou Med Univ, Taizhou Hosp Zhejiang Prov Affiliated, Dept Publ Res Platform, Linhai, Peoples R China; 6.Cedars Sinai Med Ctr, Los Angeles, CA USA; 7.Kyung Hee Univ, Dept Urol, Seoul, South Korea; 8.Wenzhou Med Univ, Dept Urol, Taizhou Hosp Zhejiang Prov, Taizhou, Peoples R China; 9.Chongqing Univ, Three Gorges Hosp, Dept Urol, Wanzhou, Chongqing, Peoples R China; 10.UCL, Div Surg & Intervent Sci, London W1W 7TS, England
通讯作者单位	附属台州医院（浙江省台州医院）; 附属台州医院
推荐引用方式 GB/T 7714	Li, Dengxiong,Yu, Qingxin,Wu, Ruicheng,et al. Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions[J]. AGING AND DISEASE,2025.
APA	Li, Dengxiong., Yu, Qingxin., Wu, Ruicheng., Tuo, Zhouting., Zhu, Weizhen., ... & Feng, Dechao. (2025). Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions. AGING AND DISEASE.
MLA	Li, Dengxiong,et al."Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions".AGING AND DISEASE (2025).