氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值

doi:10.12173/j.issn.1008-049X.202401053

科研成果详情

题名	氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值
其他题名	Application value of tranexamic acid combined with SRI-HAPAM in elderly patients with femoral neck fracture receiving total hip arthroplasty
作者	单礼旦1; 朱月英1; 陈海棠1; 黄逸爽1; 黄林拓 2
发表日期	2024-02-05
发表期刊	中国药师影响因子和分区
语种	中文
原始文献类型	学术期刊
关键词	氨甲环酸健康行为过程取向模型阶段式康复干预老年股骨颈骨折全髋关节置换术
其他关键词	Tranexamic acid ; Staged rehabilitation intervention ; Health action process approach ; Femoral neck fracture in the elderly ; Replacement of total hip
摘要	目的探究氨甲环酸（TXA）联合健康行为过程取向模型（HAPA）下阶段式康复干预（SRI-HAPAM）对行全髋关节置换术（THA）老年股骨颈骨折（FNF）患者的应用价值。方法纳入2022年12月至2023年6月温州医科大学附属第一医院行单侧THA老年FNF患者为研究对象。根据随机数字表法，将患者为常规护理（RN）组和TXA+SRI-HAPAM组。RN组术后接受常规治疗, TXA+SRI-HAPAM组术后接受TXA联合SRI-HAPAM治疗。比较两组术后24 h出血指标[隐性失血量（HBL）、显性出血量（EBL）和输血量（BTV）]、血红蛋白（Hb）、C-反应蛋白（CRP）和D-二聚体（DD）水平。比较两组术后3个月髋关节功能[关节畸形（JD）、关节功能（JF）、关节疼痛（JP）、关节活动（JM）和髋关节功能总分（THF）]、焦虑抑郁情绪[焦虑自评量表（SAS）和抑郁自评量表（SDS）]、护理满意度和并发症发生情况。结果研究共纳入100例因FNF行单侧THA老年患者，TXA+SRI-HAPAM组54例，RN组46例。术前，两组Hb、CRP、DD、JD、JF、JP、JM、THF、SAS差异无统计学意义（P> 0.05）。术后24 h，两组Hb较术前下降，而CRP和DD较术前上升（P <0.05）;TXA+SRI-HAPAM组Hb的下降程度和CRP、DD的上升程度以及HBL、EBL和BTV均低于RN组（P <0.05）。术后3月，两组患者JD、JF、JP、JM和THF均较术前上升，而SAS和SDS较术前均下降（P <0.05）；且TXA+SRI-HAPAM组JD、JF、JP、JM和THF评分显著高于RN组，SAS和SDS评分低于RN组（P <0.05）。术后3个月，TXA+SRI-HAPAM组护理满意度明显高于RN组，而总并发症发生率低于RN组（P <0.05）。结论与常规护理比较，TXA联合SRIHAPAM可更有效地促进THA患者术后恢复。
其他摘要	Objective To explore the application value of stage rehabilitation intervention under the Health action process approach(HAPA)model(SRI-HAPAM)combined with tranexamic acid(TXA)in elderly patients with femoral neck fracture(FNF)undergoing total hip arthroplasty(THA).Methods Elderly FNF patients with unilateral THA in the First Affiliated Hospital of Wenzhou Medical University from December 2022 to June 2023 were enrolled.According to the random number table method,the patients were divided into routine nursing(RN)group and TXA+SRI-HAPAM group.The RN group received conventional treatment after surgery,and the TXA+SRI-HAPAM group received TXA combined with SRI-HAPAM after surgery.The bleeding indexes[hidden blood loss(HBL),explicit blood loss(EBL)and blood transfusion volume(BTV)],and the levels of hemoglobin(Hb),C-reactive protein(CRP)and D-dimer(DD)were compared between the two groups at 24 h after surgery.The hip function[joint deformity(JD),joint function(JF),joint pain(JP),joint motion(JM)and total hip function(THF)],anxiety and depression[self-rating anxiety scale and self-rating depression scale],satisfaction with care,and complications were compared between the two groups at 3 months after surgery.Results A total of 100 elderly patients with unilateral THA due to FNF were included in the study,including 54 in the TXA+SRI-HAPAM group and 46 in the RN group.Before operation,there was no significant difference in Hb,CRP,DD,JD,JF,JP,JM,THF and SAS between the two groups(P0.05).At 24 hours after operation,Hb decreased in the two groups,while CRP and DD increased(P<0.05),and the decrease in Hb and the increase in CRP and DD,as well as HBL,EBL and BTV in the TXA+SRI-HAPAM group,were lower than those in the RN group(P<0.05).At 3 months after operation,JD,JF,JP,JM and THF in both groups increased compared with those before operation,while SAS and SDS decreased compared with those before operation(P<0.05),and the functional scores of JD,JF,JP,JM and THF in the TXA+SRI-HAPAM group were significantly higher than those in the RN group,and the scores of SAS and SDS were lower than those in the RN group(P<0.05).3 months after surgery,the nursing satisfaction of the TXA+SRI-HAPAM group was significantly higher than that of the RN group,and the total complication rate was lower than that of the RN group(P<0.05).Conclusion Compared the Routine nursing,TXA combined with SRI-HAPAM more effectively promotes postoperative recovery in patients with THA.
资助项目	温州市基础性科研项目（Y20201009）;
ISSN	1008-049X
卷号	27 期号:02 页码:279-286
DOI	10.12173/j.issn.1008-049X.202401053
页数	8
收录类别	CNKI ; 万方 ; 维普
URL	查看原文
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210536
专题	附属第一医院附属第一医院_骨科
通讯作者	黄林拓
作者单位	1.温州医科大学附属第一医院骨科护理单元; 2.温州医科大学附属第一医院骨科
第一作者单位	附属第一医院; 骨科
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	单礼旦,朱月英,陈海棠,等. 氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值[J]. 中国药师,2024,27(02):279-286.
APA	单礼旦, 朱月英, 陈海棠, 黄逸爽, & 黄林拓. (2024). 氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值. 中国药师, 27(02), 279-286.
MLA	单礼旦,et al."氨甲环酸联合SRI-HAPAM在老年股骨颈骨折全髋关节置换术后的应用价值".中国药师 27.02(2024):279-286.