Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration

doi:10.1016/j.mtbio.2024.101007

科研成果详情

题名	Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration
作者	Zhang, Qihong; Wu, Shuyi; Sun, Yingyue; Ru Yie, Kendrick Hii; Zhuang, Jiatong; Liu, Tingting; Si, Wen; Zhang, Yinyan; Liu, Zheyuan; Xiong, Lifeng; Lu, Lei; Gao, Peng; Liu, Jinsong
发表日期	2024-04
发表期刊	Materials Today Bio 影响因子和分区
语种	英语
原始文献类型	Journal article (JA)
关键词	Bone Chemical stability Ions Metal implants Molluscs Protective coatings Strontium Zirconia Amino group Bone integration Cells adhesion Functionalizations Integrin targeting Mussel byssus Osteogenesis Osteogenic activity Strontium ion Zirconium implant
其他关键词	SURFACE MODIFICATIONS ; CHEMISTRY ; COATINGS
摘要	Zirconia faces challenges in dental implant applications due to its inherent biological inertness, which compromises osseointegration, a critical factor for the long-term success of implants that rely heavily on specific cell adhesion and enhanced osteogenic activity. Here, we fabricated a dual-functional coating that incorporates strontium ions, aimed at enhancing osteogenic activity, along with an integrin-targeting sequence to improve cell adhesion by mussel byssus-inspired surface chemistry. The results indicated that although the integrin-targeting sequence at the interface solely enhances osteoblast adhesion without directly increasing osteogenic activity, its synergistic interaction with the continuously released strontium ions from the coating, as compared to the release of strontium ions alone, significantly enhances the overall osteogenic effect. More importantly, compared to traditional polydopamine surface chemistry, the coating surface is enriched with amino groups capable of undergoing various chemical reactions and exhibits enhanced stability and aesthetic appeal. Therefore, the synergistic interplay between strontium and the functionally customizable surface offers considerable potential to improve the success of zirconia implantation. © 2024 The Authors
资助项目	Fundamental Research Funds for Wenzhou Medical University[KYYW202208];Wenzhou Major Science and Technology Innovation Project[ZZN2023001];National Natural Science Foundation of China[82071170,82301156,82371016];Zhejiang Provincial Natural Science Foundation of China[LTGY23H140001];
出版者	Elsevier B.V.
ISSN	2590-0064
EISSN	2590-0064
卷号	25
DOI	10.1016/j.mtbio.2024.101007
页数	11
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS研究方向	Engineering ; Materials Science
WOS记录号	WOS:001196118300001
收录类别	EI ; SCOPUS ; SCIE
在线发表日期	2024-02
EI入藏号	20240915650640
EI主题词	Cell adhesion
EI分类号	461.2 Biological Materials and Tissue Engineering ; 461.9 Biology ; 462.4 Prosthetics ; 471 Marine Science and Oceanography ; 549.2 Alkaline Earth Metals ; 801 Chemistry ; 804.2 Inorganic Compounds
URL	查看原文
PubMed ID	38779617
SCOPUSEID	2-s2.0-85185888179
通讯作者地址	[Gao, Peng]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Lu, Lei]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China ; [Liu, Jinsong]School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Biotechnology;Bioengineering;Biomaterials;Biomedical Engineering;Molecular Biology;Cell Biology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210407
专题	口腔医学院、附属口腔医院
通讯作者	Lu, Lei; Gao, Peng; Liu, Jinsong
作者单位	School and Hospital of Stomatology,Wenzhou Medical University,Wenzhou,325027,China
第一作者单位	口腔医学院、附属口腔医院
通讯作者单位	口腔医学院、附属口腔医院
第一作者的第一单位	口腔医学院、附属口腔医院
推荐引用方式 GB/T 7714	Zhang, Qihong,Wu, Shuyi,Sun, Yingyue,et al. Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration[J]. Materials Today Bio,2024,25.
APA	Zhang, Qihong., Wu, Shuyi., Sun, Yingyue., Ru Yie, Kendrick Hii., Zhuang, Jiatong., ... & Liu, Jinsong. (2024). Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration. Materials Today Bio, 25.
MLA	Zhang, Qihong,et al."Mussel byssus-inspired dual-functionalization of zirconia dental implants for improved bone integration".Materials Today Bio 25(2024).