Environmentally relevant exposure to cotinine induces neurobehavioral toxicity in zebrafish (Danio rerio): A study using neurobehavioral and metabolomic approaches

doi:10.1016/j.envpol.2024.123826

科研成果详情

题名	Environmentally relevant exposure to cotinine induces neurobehavioral toxicity in zebrafish (Danio rerio): A study using neurobehavioral and metabolomic approaches
作者	Yang, Dan 1; Yu, Wenfei 1; Qu, Jiajia 1; Shen, Yuexing 1; Yu, Jingtong 1; Meng, Ruirui 1; Tao, Zhen 1; Chen, Jiangfei 2; Du, Wei 3; Sun, Haitong Zhe 4,5; Zhang, Yunhui 6; Chen, Yuanchen 1,7; Zhao, Meirong 1
发表日期	2024-05-01
发表期刊	Environmental pollution (Barking, Essex : 1987) 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Metabolomics Neurobehavioral toxicity Neurotransmitter Psychoactive substances
其他关键词	WASTE-WATER ; SEROTONIN ; NICOTINE ; TRANSFORMATION ; ASPARTATE ; MELATONIN ; BEHAVIOR
摘要	As an important psychoactive substance, cotinine is ubiquitous in aquatic environment and poses a threat to aquatic organisms. However, the mechanism of its adverse health impacts remains unclear. We evaluated the effects of cotinine exposure at environmentally relevant concentrations on the development and locomotor behavior of zebrafish (Danio rerio) larvae using neurotransmitters and whole endogenous metabolism. Mild developmental toxicity and significant neurobehavior disorder, such as spontaneous movement (1-1000 μg/L), 48 hpf tactile response (50, 100, and 1000 μg/L), and 144 hpf swimming speed (1, 10, 100, 500, and 1000 μg/L), were observed in zebrafish. Exposure to cotinine led to significant alterations in 11 neurotransmitters, including homogentisic acid, serotonin, glutamic acid and aspartic acid, etc. 298 metabolites were identified and two pathways - linoleic acid metabolism and taurine and hypotaurine metabolism - were delineated. In addition, amino acid neurotransmitters were significantly correlated with metabolites such as arachidonic acid as well as its derivatives, steroidal compounds, and amino acids. Serotonin demonstrates a noteworthy correlation with 31 out of 40 differentially expressed neurotransmitters, encompassing lipids, amino acids, and other compounds. These novel findings contribute to a comprehensive understanding of the ecological risks associated with cotinine contamination in surface waters.
资助项目	National Natural Science Foundation of China[42177390];Zhejiang Natural Science Foundation[LY20D010010];
出版者	Elsevier Ltd
ISSN	0269-7491
EISSN	1873-6424
卷号	348
DOI	10.1016/j.envpol.2024.123826
页数	9
WOS类目	Environmental Sciences
WOS研究方向	Environmental Sciences & Ecology
WOS记录号	WOS:001215901200001
收录类别	PUBMED ; EI ; SCIE ; SCOPUS
EI入藏号	20241315811667
EI主题词	Amino acids
EI分类号	461.6 Medicine and Pharmacology ; 461.7 Health Care ; 471 Marine Science and Oceanography ; 804.1 Organic Compounds
URL	查看原文
PubMed ID	38513941
SCOPUSEID	2-s2.0-85188512916
通讯作者地址	[Chen, Yuanchen]Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province,College of Environment,Zhejiang University of Technology,Zhejiang,Hangzhou,310032,China
Scopus学科分类	Toxicology;Pollution;Health, Toxicology and Mutagenesis
TOP期刊	TOP期刊
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210347
专题	公共卫生学院_环境安全与健康风险评估研究院公共卫生学院_健康与环境生态研究所
通讯作者	Chen, Yuanchen
作者单位	1.Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province,College of Environment,Zhejiang University of Technology,Zhejiang,Hangzhou,310032,China; 2.Institute of Environmental Safety and Human Health,School of Public Health and Management,Wenzhou Medical University,Wenzhou,325035,China; 3.Yunnan Provincial Key Laboratory of Soil Carbon Sequestration and Pollution Control,Faculty of Environmental Science & Engineering,Kunming University of Science &Technology,Kunming,650500,China; 4.Yusuf Hamied Department of Chemistry,University of Cambridge,Cambridge,CB2 1EW,United Kingdom; 5.Department of Earth Sciences,University of Cambridge,Cambridge,CB2 3EQ,United Kingdom; 6.College of Environmental Science and Engineering,Tongji University,Shanghai,200092,China; 7.Innovation Research Center of Advanced Environmental Technology,Eco-Industrial Innovation Institute ZJUT,Zhejiang,Quzhou,324400,China
推荐引用方式 GB/T 7714	Yang, Dan,Yu, Wenfei,Qu, Jiajia,et al. Environmentally relevant exposure to cotinine induces neurobehavioral toxicity in zebrafish (Danio rerio): A study using neurobehavioral and metabolomic approaches[J]. Environmental pollution (Barking, Essex : 1987),2024,348.
APA	Yang, Dan., Yu, Wenfei., Qu, Jiajia., Shen, Yuexing., Yu, Jingtong., ... & Zhao, Meirong. (2024). Environmentally relevant exposure to cotinine induces neurobehavioral toxicity in zebrafish (Danio rerio): A study using neurobehavioral and metabolomic approaches. Environmental pollution (Barking, Essex : 1987), 348.
MLA	Yang, Dan,et al."Environmentally relevant exposure to cotinine induces neurobehavioral toxicity in zebrafish (Danio rerio): A study using neurobehavioral and metabolomic approaches".Environmental pollution (Barking, Essex : 1987) 348(2024).