Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma

doi:10.1167/iovs.65.3.28

科研成果详情

题名	Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma
作者	Chen, De-Fu1,2; Wang, Chenmin1,2; Si, Yuqing1,2; Lu, Xiaonan1,2; Zhou, Weihe1; Huang, Qiangjie1; Zuo, Jingjing 1,2; Cheng, Gangwei 3; Leung, Dexter Y.L.4; Wang, Ningli 5; Friedman, David S.6; Liang, Yuanbo1,2
发表日期	2024-03
发表期刊	Investigative ophthalmology & visual science 影响因子和分区
语种	英语
原始文献类型	Observational Study ; Journal Article
关键词	normal-tension glaucoma natural history progression risk factors
其他关键词	OPEN-ANGLE GLAUCOMA ; VISUAL-FIELD PROGRESSION ; INTRAOCULAR-PRESSURE ; POPULATION ; PREVALENCE
摘要	To characterize the natural history of normal-tension glaucoma (NTG) in Chinese patients., The prospective observational cohort study included patients with untreated NTG with a minimum follow-up of 2 years. Functional progression was defined by visual field (VF) deterioration, while structural progression was characterized by thinning of the retinal nerve fiber layer (RNFL) or ganglion cell inner plexiform layer (GCIPL)., Among 84 participants (mean age, 60.5 years; mean deviation, -5.01 decibels [dB]) with newly diagnosed NTG followed for an average of 69.7 months, 63.1% progressed during the observation period. Specifically, 29.8% progressed by VF, and 48.8% progressed by either RNFL or GCIPL. In Cox proportional hazards analysis, disc hemorrhage (hazard ratio [HR], 2.82; 95% confidence interval [CI], 1.48-5.35), female gender (HR, 1.98; 95% CI, 1.08-3.62), and mean IOP during the follow-up period (HR, 1.14 per mm Hg; 95% CI, 1.00-1.31) were significant predictors of glaucomatous progression. Additionally, longer axial length (AL; HR, 0.57 per millimeter; 95% CI, 0.35-0.94) was protective against VF progression faster than -0.50 dB/y, and higher minimum diastolic blood pressure (DBP; HR, 0.96 per mm Hg; 95% CI, 0.92-1.00) was protective against structural progression., Nearly two-thirds of untreated Chinese patients with NTG progressed over an average follow-up of 70 months by VF, RNFL, or GCIPL. Disc hemorrhage, female gender, higher mean IOP, shorter AL, and lower minimum DBP were significant predictors for disease progression.
资助项目	Program for Zhejiang Leading Talent of S&T Innovation[2021R52012];Key Research and Development Projects of Zhejiang Province[2022C03112];
出版者	ASSOC RESEARCH VISION OPHTHALMOLOGY INC
ISSN	0146-0404
EISSN	1552-5783
卷号	65 期号:3
DOI	10.1167/iovs.65.3.28
页数	9
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:001208353700010
收录类别	PUBMED ; SCIE ; SCOPUS
URL	查看原文
PubMed ID	3850685
SCOPUSEID	2-s2.0-85188760689
通讯作者地址	[Liang, Yuanbo]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,No. 270 Xue Yuan Xi Road,Wenzhou,325000,China
Scopus学科分类	Ophthalmology;Sensory Systems;Cellular and Molecular Neuroscience
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210329
专题	眼视光学院（生物医学工程学院）、附属眼视光医院眼视光学院（生物医学工程学院）、附属眼视光医院_杭州院区_青光眼专科
通讯作者	Liang, Yuanbo
作者单位	1.National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,China; 2.Glaucoma Research Institute,Wenzhou Medical University,Wenzhou,China; 3.Key Laboratory of Ocular Fundus Diseases,Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences,Beijing,China; 4.Department of Ophthalmology,Hong Kong Sanatorium and Hospital,Hong Kong; 5.Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Ophthalmology & Visual Science Key Lab,Beijing,China; 6.Glaucoma Center of Excellence,Massachusetts Eye and Ear,Harvard Medical School,Boston,United States
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院; 温州医科大学
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Chen, De-Fu,Wang, Chenmin,Si, Yuqing,et al. Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma[J]. Investigative ophthalmology & visual science,2024,65(3).
APA	Chen, De-Fu., Wang, Chenmin., Si, Yuqing., Lu, Xiaonan., Zhou, Weihe., ... & Liang, Yuanbo. (2024). Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma. Investigative ophthalmology & visual science, 65(3).
MLA	Chen, De-Fu,et al."Natural History and Risk Factors for Glaucoma Progression in Chinese Patients With Normal-Tension Glaucoma".Investigative ophthalmology & visual science 65.3(2024).