The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study

doi:10.3389/fendo.2024.1327041

科研成果详情

题名	The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study
作者	Huang, Wenle 1; Liu, Chang 2; Ding, Lin 3,4; Li, Yan2; Zhou, Haisu2; Wang, Shuwei 5; Yang, Haiyan2
发表日期	2024-03-05
发表期刊	Frontiers in endocrinology 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	IVF outcome hyperinsulinemia insulin resistance polycystic ovary syndrome β-Cell dysfunction
其他关键词	PREGNANCY COMPLICATIONS ; INSULIN ; INFERTILITY ; ADAPTATION ; WOMEN
摘要	To investigate the effects of β-cell dysfunction on IVF outcomes in women with PCOS., This retrospective cohort study includes 1,212 women with PCOS undergoing their first IVF cycle between September 2010 and December 2019. Beta-cell dysfunction was measured by homeostasis model assessment of β-cell function (HOMA-β) index., {AbstractText=In quartiles of HOMA-β, the incidence of miscarriage dramatically increased from 10.2% (Q1) to 31.1% (Q4) (P for trend <0.001). Likewise, the incidence of miscarriage in quartiles of HOMA-β also showed a similar trend (P for trend <0.001). After adjusting for confounding factors, logistic regression analyses showed that high HOMA-IR values were independently associated with a high risk of miscarriage, with the odds ratios (OR) and 95% confidence intervals for quartiles 2-4 versus quartile 1 were 1.30 (0.69-2.46), 1.82 (0.97-3.43), and 3.57 (1.86-6.85), respectively (P for trend <0.001). When analyzed jointly, women in the highest HOMA-IR and highest HOMA-β group exhibited the highest risk for miscarriage compared with all other groups. Furthermore, higher HOMA-IR values were associated with higher risks of miscarriage among PCOS women regardless of HOMA-β values.}, β-cell dysfunction is independently associated with increased miscarriage rate and decreased live birth rate in women with PCOS. It also plays a synergistic role with IR in terms of the reproductive outcomes, while the influence of IR overweighs that of β-cell dysfunction.
资助项目	Health Department of Zhejiang province [2021KY785]; Wenzhou Municipal Science and Technology Bureau Foundation of Wenzhou, Zhejiang, China [Y2020517, Y20220055]; Wenzhou Key Laboratory of Reproduction and Genetics [2022HZSY0051]; Zhejiang Provincial Natural Science Foundation of China [LQ21H040010]
出版者	FRONTIERS MEDIA SA
ISSN	1664-2392
卷号	15
DOI	10.3389/fendo.2024.1327041
页数	9
WOS类目	Endocrinology & Metabolism
WOS研究方向	Endocrinology & Metabolism
WOS记录号	WOS:001186826900001
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38505754
SCOPUSEID	2-s2.0-85188099113
通讯作者地址	[Yang, Haiyan]Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China
Scopus学科分类	Endocrinology, Diabetes and Metabolism
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210324
专题	附属第一医院_生殖医学中心
通讯作者	Yang, Haiyan
作者单位	1.Department of Obstetrics and Gynecology,Wenzhou Central Hospital,Zhejiang,Wenzhou,China; 2.Reproductive Medicine Center,The First Affiliated Hospital of Wenzhou Medical University,Zhejiang,Wenzhou,China; 3.Department of Endocrinology,The Second Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan,China; 4.Department of Endocrinology and Metabology,The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital,Shandong,Jinan,China; 5.Department of Anesthesia,Zhongshan Hospital,Fudan University,Shanghai,China
通讯作者单位	附属第一医院_生殖医学中心
推荐引用方式 GB/T 7714	Huang, Wenle,Liu, Chang,Ding, Lin,et al. The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study[J]. Frontiers in endocrinology,2024,15.
APA	Huang, Wenle., Liu, Chang., Ding, Lin., Li, Yan., Zhou, Haisu., ... & Yang, Haiyan. (2024). The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study. Frontiers in endocrinology, 15.
MLA	Huang, Wenle,et al."The effect of β-cell dysfunction on reproductive outcomes of PCOS undergoing IVF or ICSI embryo transfer cycles: a retrospective cohort study".Frontiers in endocrinology 15(2024).