Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score

doi:10.1186/s12885-024-12049-4

科研成果详情

题名	Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score
作者	Lin, Jiawei1; Li, Jie 1,3; Kong, Yifan1; Yang, Junhui 1; Zhang, Yunjie1; Zhu, Guoqing2; Yu, Zhijie1; Xia, Jinglin1,3
发表日期	2024-03-06
发表期刊	BMC Cancer 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Hepatocellular carcinoma (HCC) Prognostic model Transarterial chemoembolization (TACE) Tumor Burden score (TBS)
其他关键词	ALPHA-FETOPROTEIN ; EMBOLIZATION ; NOMOGRAM ; TOOL
摘要	Patients with hepatocellular carcinoma (HCC) who undergo transarterial chemoembolization (TACE) may have varied outcomes based on their liver function and tumor burden diversity. This study aims to assess the prognostic significance of the tumor burden score (TBS) in these patients and develop a prognostic model for their overall survival., The study involved a retrospective analysis of 644 newly diagnosed HCC patients undergoing TACE treatment. The individuals were assigned randomly to a training cohort (n = 452) and a validation cohort (n = 192). We utilized a multivariate Cox proportional risk model to identify independent preoperative predictive factors. We then evaluated model performance using the area under the curve (AUC), consistency index (c-index), calibration curve, and decision curve analysis (DCA) methods., The multivariate analysis revealed four prognostic factors associated with overall survival: Tumor Burden Score, Tumor Extent, Types of portal vein invasion (PVI), and Child-Pugh score. The total score was calculated based on these factors. The model demonstrated strong discriminative ability with high AUC values and c-index, providing high net clinical benefits for patients. Based on the model's scoring results, patients were categorized into high, medium, and low-risk groups. These results were validated in the validation cohort., The tumor burden score shows promise as a viable alternative prognostic indicator for assessing tumor burden in cases of HCC. The new prognostic model can place patients in one of three groups, which will estimate their individual outcomes. For high-risk patients, it is suggested to consider alternative treatment options or provide the best supportive care, as they may not benefit significantly from TACE treatment.
资助项目	National Natural Science Foundation of China[81972233];Major scientific and technological innovation project of Wenzhou Science and Technology Bureau[ZY2021009]
出版者	BMC
ISSN	1471-2407
EISSN	1471-2407
卷号	24 期号:1
DOI	10.1186/s12885-024-12049-4
页数	15
WOS类目	Oncology
WOS研究方向	Oncology
WOS记录号	WOS:001180646300003
收录类别	PUBMED ; SCOPUS ; SCIE
URL	查看原文
PubMed ID	38448905
SCOPUSEID	2-s2.0-85187191009
通讯作者地址	[Xia, Jinglin]Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China
Scopus学科分类	Oncology;Genetics;Cancer Research
SCOPUS_ID	SCOPUS_ID:85187191009
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210219
专题	附属第一医院第一临床医学院（信息与工程学院）、附属第一医院_浙江省胰脏肝脏危重性疾病重点实验室
通讯作者	Xia, Jinglin
作者单位	1.Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 2.Department of Interventional Radiology,The First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China; 3.Liver Cancer Institute,Zhongshan Hospital of Fudan University,Shanghai,China
第一作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
通讯作者单位	附属第一医院; 第一临床医学院（信息与工程学院）、附属第一医院
第一作者的第一单位	附属第一医院
推荐引用方式 GB/T 7714	Lin, Jiawei,Li, Jie,Kong, Yifan,et al. Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score[J]. BMC Cancer,2024,24(1).
APA	Lin, Jiawei., Li, Jie., Kong, Yifan., Yang, Junhui., Zhang, Yunjie., ... & Xia, Jinglin. (2024). Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score. BMC Cancer, 24(1).
MLA	Lin, Jiawei,et al."Construction of a prognostic model for hepatocellular carcinoma patients receiving transarterial chemoembolization treatment based on the Tumor Burden Score".BMC Cancer 24.1(2024).