Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST

doi:10.1007/s40123-024-00912-3

科研成果详情

题名	Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST
作者	Fang, Wei 1; Zhou, Ziyun1; Qian, Zhenbin 1; Wang, Mengdi 1; Bao, Fangjun 1; Shen, Lijun 1,2
发表日期	2024-05
发表期刊	Ophthalmology and therapy 影响因子和分区
语种	英语
原始文献类型	Journal Article
关键词	Biomechanical phenomena Graves ophthalmopathy Retinal vessels
其他关键词	GRAVES-DISEASE ; CORNEAL ; DEFORMATION ; TOMOGRAPHY
摘要	To analyze the correlation between orbital compliance and retinal vessel density (VD) based on dynamic Scheimpflug analyzer (Corvis ST) and optical coherence tomographic angiography (OCT-A)., In this prospective observational study, 65 eyes of 44 patients with thyroid-associated ophthalmopathy (TAO) in quiescent stage were included (15 males and 29 females). The whole eye movement (WEM) was detected by Corvis ST. The superficial capillary plexus VD (SCP-VD) and deep capillary plexus VD (DCP-VD) were obtained by scanning the 3 × 3 mm area around the fovea using OCT-A, while the peripapillary vessel density (ppVD) was obtained by scanning the 4.5 × 4.5 mm area around the optic disk. Covariances including biomechanically corrected intraocular pressure (bIOP), axial length, age and gender were adjusted during data analysis., The mean WEM of the participants was 0.235 ± 0.066 mm. The mean SCP-VD and DCP-VD in whole image were 46.20% ± 3.77% and 50.51% ± 3.96%; the mean whole pp-VD was 49.75% ± 2.01%. WEM was positively correlated with SCP-VD (r = 0.327, p = 0.01) and the whole pp-VD (r = 0.394, p < 0.01) after adjusting by gender, axial length (AL), age and bIOP, but it was not significantly correlated with DCP-VD (r = 0.072 p = 0.581)., Increase in orbital pressure might reduce retinal microvascular perfusion. Our data suggest orbital mechanical compression may be an important cause of retinal VD changes in quiescent patients with TAO.
资助项目	Science and Technology Plan Project of Wenzhou Municipality
出版者	SPRINGER INT PUBL AG
ISSN	2193-8245
EISSN	2193-6528
卷号	13 期号:5 页码:1159-1170
DOI	10.1007/s40123-024-00912-3
页数	12
WOS类目	Ophthalmology
WOS研究方向	Ophthalmology
WOS记录号	WOS:001176642900001
收录类别	PUBMED ; SCOPUS ; SCIE
在线发表日期	2024-03
URL	查看原文
PubMed ID	38441857
SCOPUSEID	2-s2.0-85186581562
通讯作者地址	[Bao, Fangjun]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China ; [Shen, Lijun]National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China
Scopus学科分类	Ophthalmology
引用统计
文献类型	期刊论文
条目标识符	https://kms.wmu.edu.cn/handle/3ETUA0LF/210208
专题	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者	Bao, Fangjun; Shen, Lijun
作者单位	1.National Clinical Research Center for Ocular Diseases,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China; 2.Department of Ophthalmology,Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital),Hangzhou Medical College,Zhejiang,Hangzhou,China
第一作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
通讯作者单位	眼视光学院（生物医学工程学院）、附属眼视光医院
第一作者的第一单位	眼视光学院（生物医学工程学院）、附属眼视光医院
推荐引用方式 GB/T 7714	Fang, Wei,Zhou, Ziyun,Qian, Zhenbin,et al. Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST[J]. Ophthalmology and therapy,2024,13(5):1159-1170.
APA	Fang, Wei, Zhou, Ziyun, Qian, Zhenbin, Wang, Mengdi, Bao, Fangjun, & Shen, Lijun. (2024). Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST. Ophthalmology and therapy, 13(5), 1159-1170.
MLA	Fang, Wei,et al."Effect of Intraorbital Mechanical Compression on Retinal Microvascular Perfusion in Quiescent Thyroid-Associated Ophthalmopathy Based on Ocular Biomechanics Measured by Corvis ST".Ophthalmology and therapy 13.5(2024):1159-1170.